CIP29 (cytokine induced protein 29 kDa)

Identity

Other names	HCC-1
HGNC
Location	12q13

Note	HCC-1 is an alias for CIP29 (12q13), but also for CCL14 (17q11.2)

Protein

Description	210 amino acids, 29 kDa;contains from N term to C term a SAP domain and 2 nuclear localization domains, and also 3 possible N-glycosylation sites and 9 potential phosphorylation sites. A SAP domain is a putative DNA binding motif involved in chromosomal organization and may regulate transcription, DNA repair, RNA processing.
Expression	Widely expressed in fetal and adult tissues, as well as cancer cell lines; upregulated by EPO (erythropoietin), TPO (thrombopoietin), FL (FLT3 Ligand), and SCF (stem cell factor). Associated with cell cycle progression
Localisation	Nucleus but some staining was also found in the cytoplasm.

Implicated in

Entity	M4 acute non lymphocytic leukaemia (ANLL) with t(11;12)(q23;q13) --> (MLL/CIP29)
Note	only one case to date
Prognosis	unknown
Hybrid/Mutated Gene	5' MLL - 3' CIP29 including the 9 first exons of MLL, and nearly the entire CIP29
Abnormal Protein	The fusion protein includes from N term to C term the AT hooks and the methyltransferase domain of MLL and the SAP domain and the C term nuclear localization domains of CIP29.

External links

	Nomenclature
HGNC	-   -
Entrez_Gene	CIP29  84324  cytokine induced protein 29 kDa
	Cards
Atlas	CIP29ID42967ch12q13
GeneCards	CIP29
Ensembl	CIP29 [Search_View]   ENSG00000205323 [Gene_View]
Genatlas	CIP29
GeneLynx	CIP29
eGenome	CIP29
euGene	84324
	Genomic and cartography
GoldenPath	CIP29  -  12q13   chr12:54437325-54497773 -  12q13.2   [Description]    (hg18-Mar_2006)
Ensembl	CIP29 - 12q13.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CIP29
	Gene and transcription
Genbank	AF161434 [ ENTREZ ]
Genbank	AF486281 [ ENTREZ ]
Genbank	AK222719 [ ENTREZ ]
Genbank	AK290508 [ ENTREZ ]
Genbank	BC007099 [ ENTREZ ]
RefSeq	NM_033082 [ SRS ]    NM_033082 [ ENTREZ ]
RefSeq	AC_000055 [ SRS ]    AC_000055 [ ENTREZ ]
RefSeq	AC_000144 [ SRS ]    AC_000144 [ ENTREZ ]
RefSeq	NC_000012 [ SRS ]    NC_000012 [ ENTREZ ]
RefSeq	NT_029419 [ SRS ]    NT_029419 [ ENTREZ ]
RefSeq	NW_001838059 [ SRS ]    NW_001838059 [ ENTREZ ]
RefSeq	NW_925395 [ SRS ]    NW_925395 [ ENTREZ ]
AceView	CIP29 AceView - NCBI
Unigene	Hs.505676 [ SRS ]    Hs.505676 [ NCBI ]     HS505676 [ spliceNest ]
	Protein : pattern, domain, 3D structure
SwissProt	P82979 [ SRS]    P82979 [ EXPASY ]     P82979 [ INTERPRO ]     P82979 [ UNIPROT ]
Prosite	PS50800 SAP [ SRS ]    PS50800 SAP [ Expasy ]
Interpro	IPR003034 SAP_DNA_bd [ SRS ]    IPR003034 SAP_DNA_bd [ EBI ]
CluSTr	P82979
Pfam	PF02037 SAP [ SRS ]    PF02037 SAP [ Sanger ]    pfam02037 [ NCBI-CDD ]
Smart	SM00513 SAP [EMBL]
Blocks	P82979
PDB	2DO1 [ SRS ]    2DO1 [ PdbSum ],   2DO1 [ IMB ]   2DO1 [ RSDB ]
HPRD	16716
	Protein Interaction databases
DIP	P82979
IntAct	P82979
	Polymorphism : SNP, mutations, diseases
OMIM	610049    [ map ]
GENECLINICS	610049
SNP	CIP29 [dbSNP-NCBI]
SNP	NM_033082 [SNP-NCI]
SNP	CIP29 [GeneSNPs - Utah]  CIP29] [HGBASE - SRS]
HAPMAP	CIP29 [HAPMAP]
HGMD	-
	General knowledge
Family Browser	CIP29 [UCSC Family Browser]
SOURCE	NM_033082
SMD	Hs.505676
SAGE	Hs.505676
GO	DNA binding [Amigo]  DNA binding
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	transcription [Amigo]  transcription
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	regulation of translation [Amigo]  regulation of translation
PubGene	CIP29
TreeFam	-
CTD	84324 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
	PubMed
PubMed	15 Pubmed reference(s) in LocusLink

Bibliography

Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29.

Fukuda S, Wu DW, Stark K, Pelus LM

Biochemical and biophysical research communications. 2002 ; 292 (3) : 593-600.

PMID 11922608

A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia.

Hashii Y, Kim JY, Sawada A, Tokimasa S, Hiroyuki F, Ohta H, Makiko K, Takihara Y, Ozono K, Hara J

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2004 ; 18 (9) : 1546-1548.

PMID 15284855

Growth inhibitory effect of Hcc-1/CIP29 is associated with induction of apoptosis, not just with G2/M arrest.

Fukuda S, Pelus LM

Cellular and molecular life sciences : CMLS. 2005 ; 62 (13) : 1526-1527.

PMID 15924260

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	08-2005	Jean Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . CIP29 (cytokine induced protein 29 kDa). Atlas Genet Cytogenet Oncol Haematol. August 2005 . URL : http://AtlasGeneticsOncology.org/Genes/CIP29ID42967ch12q13.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:13:01 2008