| Description | 362 amino acids; 41522 Da |
| Expression | RDC1 is expressed in embryological, juvenile as well as adult tissues. Expression has been reported in e.g. bladder, spleen, heart, skeletal muscle, peripheral nervous system and placenta. |
| Localisation | Integral membrane protein |
| Function | Orphan receptor, but its endogenous ligand has not yet been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). RDC1 belongs to a family of G-protein coupled receptors, which includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide (G) binding proteins. |
| Homology | RDC1 displays homology to other members of the large family of G-protein coupled receptors. |
| Entity | Lipoma, |
| Disease | Benign adipocyte tumor |
| Prognosis | Good |
| Cytogenetics | Translocations involving 2q35-37 and 12q13-15 have been reported in six lipomas |
| Hybrid/Mutated Gene | Fusion between RDC1 and HMGA2 has been reported in three lipomas with rearrangement involving 2q35-37 and 12q13-15. The breakpoint occurred after the third exon of HMGA2, the most common breakpoint of this gene, and in a previously unknown 3' part of the RDC1 gene. The RDC1 part of the fusion was over 300 bp. |
| Abnormal Protein | The functional impact of this fusion is most likely a truncation of HMGA2, since the RDC1 part contributes with a stop codon one amino acid downstream of the breakpoint. |
| Oncogenesis | Not yet established |
| | |
| Entity | Tenosynovial giant cell tumours |
| Disease | Benign tumor of synovium and tendon sheath |
| Prognosis | Good |
| Cytogenetics | Translocations involving 1p11-13 and 2q35-37 have been reported in eight cases of tenosynovial giant cell tumours. |
| Hybrid/Mutated Gene | Four out of seven cases of tenosynovial giant cell tumours with aberrations of 2q35-37 had breakpoints in a BAC probe 260J21 (BACPAC, Oakland), which contains the RDC1 gene. |
| | |
| Cloning and expression of the human vasoactive intestinal peptide receptor. |
| Sreedharan SP, Robichon A, Peterson KE, Goetzl EJ |
| Proceedings of the National Academy of Sciences of the United States of America. 1991 ; 88 (11) : 4986-4990. |
| PMID 1675791 |
| |
| RDC1 may not be VIP receptor. |
| Nagata S, Ishihara T, Robberecht P, Libert F, Parmentier M, Christophe J, Vassart G |
| Trends in pharmacological sciences. 1992 ; 13 (3) : 102-103. |
| PMID 1315461 |
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| A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses. |
| Shimizu N, Soda Y, Kanbe K, Liu HY, Mukai R, Kitamura T, Hoshino H |
| Journal of virology. 2000 ; 74 (2) : 619-626. |
| PMID 10623723 |
| |
| Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. |
| Broberg K, Zhang M, Strmbeck B, Isaksson M, Nilsson M, Mertens F, Mandahl N, Panagopoulos I |
| International journal of oncology. 2002 ; 21 (2) : 321-326. |
| PMID 12118328 |
| |
| Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors. |
| Nilsson M, Hglund M, Panagopoulos I, Sciot R, Dal Cin P, Debiec-Rychter M, Mertens F, Mandahl N |
| Virchows Archiv : an international journal of pathology. 2002 ; 441 (5) : 475-480. |
| PMID 12447678 |
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| Vascular gene expression in nonneoplastic and malignant brain. |
| Madden SL, Cook BP, Nacht M, Weber WD, Callahan MR, Jiang Y, Dufault MR, Zhang X, Zhang W, Walter-Yohrling J, Rouleau C, Akmaev VR, Wang CJ, Cao X, St Martin TB, Roberts BL, Teicher BA, Klinger KW, Stan RV, Lucey B, Carson-Walter EB, Laterra J, Walter KA |
| The American journal of pathology. 2004 ; 165 (2) : 601-608. |
| PMID 15277233 |
| |