DDX10

Identity

Other names	HRH-J8
Hugo	DDX10
Location	11q22
Local_order	telomeric to ATM.
	DDX10 (11q22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it

DNA/RNA

Description	at least 12 exons; spans more than a 200-kb region
Transcription	alternative splicing; 3.2 and 5.0 kb mRNA

Protein

Description	contains 2 nuclear localization signals (NLS), a DEAD box (DEAD for: ASP-GLU_ALA-ASP)
Expression	wide
Localisation	nucleolus (probable)
Function	putative ATP-dependent DEAD box RNA helicase; possible role in ribosome assembly through rRNA processing
Homology	SPB4 and DRS1 (yeast)

Implicated in

Entity	inv (11)(p15q22)/MDS or ANLL --> NUP98-DDX10
Disease	therapy related MDS and ANLL; de novo ANLL
Hybrid/Mutated Gene	5' NUP98 - 3' DDX10
Abnormal Protein	fuses the GLFG repeat domains of NUP98 to the charged amino acids domain of DDX11

External links

	Nomenclature
Hugo	DDX10
GDB	DDX10
Entrez_Gene	DDX10  1662  DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
	Cards
Atlas	DDX10
GeneCards	DDX10
Ensembl	DDX10 [Search_View]   ENSG00000178105 [Gene_View]
Genatlas	DDX10
GeneLynx	DDX10
eGenome	DDX10
euGene	1662
	Genomic and cartography
GoldenPath	DDX10  -  11q22   chr11:108041026-108316856 +  11q22-q23   [Description]    (hg18-Mar_2006)
Ensembl	DDX10 - 11q22-q23 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	DDX10
	Gene and transcription
Genbank	AB001343 [ ENTREZ ]
Genbank	AB040537 [ ENTREZ ]
Genbank	AB209884 [ ENTREZ ]
Genbank	BC049217 [ ENTREZ ]
Genbank	BC064921 [ ENTREZ ]
RefSeq	NM_004398 [ SRS ]    NM_004398 [ ENTREZ ]
RefSeq	AC_000054 [ SRS ]    AC_000054 [ ENTREZ ]
RefSeq	NC_000011 [ SRS ]    NC_000011 [ ENTREZ ]
RefSeq	NT_033899 [ SRS ]    NT_033899 [ ENTREZ ]
RefSeq	NW_925173 [ SRS ]    NW_925173 [ ENTREZ ]
AceView	DDX10 AceView - NCBI
Unigene	Hs.591931 [ SRS ]    Hs.591931 [ NCBI ]     HS591931 [ spliceNest ]
Fast-db	13672 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q13206 [ SRS]    Q13206 [ EXPASY ]     Q13206 [ INTERPRO ]
Prosite	PS00039 DEAD_ATP_HELICASE [ SRS ]    PS00039 DEAD_ATP_HELICASE [ Expasy ]
Prosite	PS51192 HELICASE_ATP_BIND_1 [ SRS ]    PS51192 HELICASE_ATP_BIND_1 [ Expasy ]
Prosite	PS51194 HELICASE_CTER [ SRS ]    PS51194 HELICASE_CTER [ Expasy ]
Prosite	PS51195 Q_MOTIF [ SRS ]    PS51195 Q_MOTIF [ Expasy ]
Interpro	IPR014001 DEAD-like_N [ SRS ]    IPR014001 DEAD-like_N [ EBI ]
Interpro	IPR001650 DNA/RNA_helicase_C [ SRS ]    IPR001650 DNA/RNA_helicase_C [ EBI ]
Interpro	IPR011545 DNA/RNA_helicase_DEAD/DEAH_N [ SRS ]    IPR011545 DNA/RNA_helicase_DEAD/DEAH_N [ EBI ]
Interpro	IPR014021 Helicase_SF1/SF2_ATP-bd [ SRS ]    IPR014021 Helicase_SF1/SF2_ATP-bd [ EBI ]
Interpro	IPR000629 RNA-helicase_DEAD-box_CS [ SRS ]    IPR000629 RNA-helicase_DEAD-box_CS [ EBI ]
Interpro	IPR014014 RNA_helicase_DEAD_Q_motif [ SRS ]    IPR014014 RNA_helicase_DEAD_Q_motif [ EBI ]
CluSTr	Q13206
Pfam	PF00270 DEAD [ SRS ]    PF00270 DEAD [ Sanger ]    pfam00270 [ NCBI-CDD ]
Pfam	PF00271 Helicase_C [ SRS ]    PF00271 Helicase_C [ Sanger ]    pfam00271 [ NCBI-CDD ]
Smart	SM00487 DEXDc [EMBL]
Smart	SM00490 HELICc [EMBL]
Blocks	Q13206
PDB	2PL3 [ SRS ]    2PL3 [ PdbSum ],   2PL3 [ IMB ]   2PL3 [ RSDB ]
HPRD	03138
	Protein Interaction databases
DIP	Q13206
IntAct	Q13206
	Polymorphism : SNP, mutations, diseases
OMIM	601235    [ map ]
GENECLINICS	601235
SNP	DDX10 [dbSNP-NCBI]
SNP	NM_004398 [SNP-NCI]
SNP	DDX10 [GeneSNPs - Utah]  DDX10] [HGBASE - SRS]
HAPMAP	DDX10 [HAPMAP]
COSMIC	DDX10 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	DDX10 [Translocation breakpoints In Cancer]
HGMD	DDX10
	General knowledge
Family Browser	DDX10 [UCSC Family Browser]
SOURCE	NM_004398
SMD	Hs.591931
SAGE	Hs.591931
Enzyme	3.6.1.- [ Enzyme-SRS ]   3.6.1.- [ Brenda-SRS ]   3.6.1.- [ KEGG ]   3.6.1.- [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	RNA binding [Amigo]  RNA binding
GO	RNA helicase activity [Amigo]  RNA helicase activity
GO	ATP binding [Amigo]  ATP binding
GO	ATP-dependent helicase activity [Amigo]  ATP-dependent helicase activity
GO	hydrolase activity [Amigo]  hydrolase activity
PubGene	DDX10
TreeFam	DDX10
CTD	1662 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	Cancer Cytogenetics (Bari)
Probe	DDX10 Related clones (RZPD - Berlin)
	PubMed
PubMed	12 Pubmed reference(s) in LocusLink

Bibliography

A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.

Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G

Genomics. 1996 ; 33 (2) : 199-206.

PMID 8660968

The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.

Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M

Blood. 1997 ; 89 (11) : 3936-3944.

PMID 9166830

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	01-1998	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . DDX10. Atlas Genet Cytogenet Oncol Haematol. January 1998 . URL : http://AtlasGeneticsOncology.org/Genes/DDX10.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:23:00 2008