DEK

Identity

HGNC	DEK
Location	6p23
	DEK (6p23) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it

DNA/RNA

Description	spans on a 40 kb genomic segment
Transcription	2.7 kb mRNA; coding sequence: 1.1 kb

Protein

Description	375 amino acids; 43 kDa; contains numerous acidic domains (Asp/Glu rich) and a nuclear localisation signal
Expression	wide
Localisation	potentially nuclear
Function	site specific DNA binding protein involved in transcriptional regulation and signal transduction

Implicated in

Entity	t(6;9)(p23;q34)/ANLL or MDS -->DEK-CAN
Disease	M2, M4 ANLL or MDS
Prognosis	remission difficult to obtain
Cytogenetics	this chromosome anomaly may be over loocked
Hybrid/Mutated Gene	5' DEK - 3' CAN; chromosome 6 breakpoint clusters in a single intron
Abnormal Protein	head to tail DEK/CAN fusion protein (the alternative SET/CAN is exceptional); almost the entire DEK protein fused to the C-terminal two-thirds of the CAN protein; nuclear localization

External links

	Nomenclature
HGNC	DEK   2768
Entrez_Gene	DEK  7913  DEK oncogene (DNA binding)
	Cards
Atlas	DEK_23
GeneCards	DEK
Ensembl	DEK [Search_View]   ENSG00000124795 [Gene_View]
Genatlas	DEK
GeneLynx	DEK
eGenome	DEK
euGene	7913
	Genomic and cartography
GoldenPath	DEK  -  6p23   chr6:18332379-18372778 -  6p22.3   [Description]    (hg18-Mar_2006)
Ensembl	DEK - 6p22.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	DEK
	Gene and transcription
Genbank	AJ270688 [ ENTREZ ]
Genbank	AJ420539 [ ENTREZ ]
Genbank	AK312616 [ ENTREZ ]
Genbank	AU131262 [ ENTREZ ]
Genbank	BC012442 [ ENTREZ ]
RefSeq	NM_003472 [ SRS ]    NM_003472 [ ENTREZ ]
RefSeq	AC_000049 [ SRS ]    AC_000049 [ ENTREZ ]
RefSeq	AC_000138 [ SRS ]    AC_000138 [ ENTREZ ]
RefSeq	NC_000006 [ SRS ]    NC_000006 [ ENTREZ ]
RefSeq	NT_007592 [ SRS ]    NT_007592 [ ENTREZ ]
RefSeq	NW_001838973 [ SRS ]    NW_001838973 [ ENTREZ ]
RefSeq	NW_922984 [ SRS ]    NW_922984 [ ENTREZ ]
AceView	DEK AceView - NCBI
Unigene	Hs.712552 [ SRS ]    Hs.712552 [ NCBI ]     HS712552 [ spliceNest ]
Fast-db	3147 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P35659 [ SRS]    P35659 [ EXPASY ]     P35659 [ INTERPRO ]     P35659 [ UNIPROT ]
Prosite	PS50800 SAP [ SRS ]    PS50800 SAP [ Expasy ]
Interpro	IPR014876 DEK_C [ SRS ]    IPR014876 DEK_C [ EBI ]
Interpro	IPR003034 SAP_DNA_bd [ SRS ]    IPR003034 SAP_DNA_bd [ EBI ]
CluSTr	P35659
Pfam	PF08766 DEK_C [ SRS ]    PF08766 DEK_C [ Sanger ]    pfam08766 [ NCBI-CDD ]
Pfam	PF02037 SAP [ SRS ]    PF02037 SAP [ Sanger ]    pfam02037 [ NCBI-CDD ]
Smart	SM00513 SAP [EMBL]
Blocks	P35659
PDB	1Q1V [ SRS ]    1Q1V [ PdbSum ],   1Q1V [ IMB ]   1Q1V [ RSDB ]
PDB	2JX3 [ SRS ]    2JX3 [ PdbSum ],   2JX3 [ IMB ]   2JX3 [ RSDB ]
HPRD	00503
	Protein Interaction databases
DIP	P35659
IntAct	P35659
	Polymorphism : SNP, mutations, diseases
OMIM	125264    [ map ]
GENECLINICS	125264
SNP	DEK [dbSNP-NCBI]
SNP	NM_003472 [SNP-NCI]
SNP	DEK [GeneSNPs - Utah]  DEK] [HGBASE - SRS]
HAPMAP	DEK [HAPMAP]
COSMIC	DEK [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	DEK [Translocation breakpoints In Cancer]
HGMD	DEK
	General knowledge
Family Browser	DEK [UCSC Family Browser]
SOURCE	NM_003472
SMD	Hs.712552
SAGE	Hs.712552
GO	DNA binding [Amigo]  DNA binding
GO	specific RNA polymerase II transcription factor activity [Amigo]  specific RNA polymerase II transcription factor activity
GO	nucleus [Amigo]  nucleus
GO	regulation of transcription from RNA polymerase II promoter [Amigo]  regulation of transcription from RNA polymerase II promoter
GO	signal transduction [Amigo]  signal transduction
GO	viral genome replication [Amigo]  viral genome replication
GO	histone binding [Amigo]  histone binding
PubGene	DEK
TreeFam	DEK
CTD	7913 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	Cancer Cytogenetics (Bari)
Probe	DEK Related clones (RZPD - Berlin)
	PubMed
PubMed	53 Pubmed reference(s) in LocusLink

Bibliography

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G

Molecular and cellular biology. 1992 ; 12 (4) : 1687-1697.

PMID 1549122

Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements.

Fornerod M, Boer J, van Baal S, Jaeglˆ© M, von Lindern M, Murti KG, Davis D, Bonten J, Buijs A, Grosveld G

Oncogene. 1995 ; 10 (9) : 1739-1748.

PMID 7753551

Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN.

Fornerod M, Boer J, van Baal S, Morreau H, Grosveld G

Oncogene. 1996 ; 13 (8) : 1801-1808.

PMID 8895527

DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer.

Fu GK, Grosveld G, Markovitz DM

Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (5) : 1811-1815.

PMID 9050861

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	01-1998	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . DEK. Atlas Genet Cytogenet Oncol Haematol. January 1998 . URL : http://AtlasGeneticsOncology.org/Genes/DEK_23.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:13:16 2008