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| Description | EPHA7 encodes 998 amino acids, theoretical pI is 5.58, theoretical molecular weight is 112 KDa, tyrosine kinase, catalytic domain, sterile alpha motif, 2 fibronectin type 3 domains, ephrin receptor ligand binding domain and tumor necrosis factor receptor domain. |
| Expression | in brain, skeletal muscle, lung, kidney, liver, colorectum and nerve system. |
| Localisation | Located in the membrane. |
| Function | ATP Binding, ephrin receptor activity, nucleotide binding, protein binding, receptor activity, transferase activity. |
| Homology | Homo sapiens: EPHA5 isoform b [NP_872272] (64%), EPHA5 isoform a [NP_004430] (63%), EPHA4 [NP_004429] (63%), EPHA3 [AAG43576] (63%). |
| Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. |
| Holmberg J, Clarke DL, Frisˆ©n J |
| Nature. 2000 ; 408 (6809) : 203-206. |
| PMID 11089974 |
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| Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. |
| Hafner C, Schmitz G, Meyer S, Bataille F, Hau P, Langmann T, Dietmaier W, Landthaler M, Vogt T |
| Clinical chemistry. 2004 ; 50 (3) : 490-499. |
| PMID 14726470 |
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| Downregulation of EphA7 by hypermethylation in colorectal cancer. |
| Wang J, Kataoka H, Suzuki M, Sato N, Nakamura R, Tao H, Maruyama K, Isogaki J, Kanaoka S, Ihara M, Tanaka M, Kanamori M, Nakamura T, Shinmura K, Sugimura H |
| Oncogene. 2005 ; 24 (36) : 5637-5647. |
| PMID 16007213 |
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| Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery. |
| Figueroa JD, Benton RL, Velazquez I, Torrado AI, Ortiz CM, Hernandez CM, Diaz JJ, Magnuson DS, Whittemore SR, Miranda JD |
| Journal of neuroscience research. 2006 ; 84 (7) : 1438-1451. |
| PMID 16983667 |
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| Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer. |
| Hafner C, Becker B, Landthaler M, Vogt T |
| Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2006 ; 19 (10) : 1369-1377. |
| PMID 16862074 |
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| Absence of tyrosine kinase mutations in Japanese colorectal cancer patients. |
| Shao RX, Kato N, Lin LJ, Muroyama R, Moriyama M, Ikenoue T, Watabe H, Otsuka M, Guleng B, Ohta M, Tanaka Y, Kondo S, Dharel N, Chang JH, Yoshida H, Kawabe T, Omata M |
| Oncogene. 2007 ; 26 (14) : 2133-2135. |
| PMID 17016444 |
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| Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. |
| Zhao X, Sun M, Zhao J, Leyva JA, Zhu H, Yang W, Zeng X, Ao Y, Liu Q, Liu G, Lo WH, Jabs EW, Amzel LM, Shan X, Zhang X |
| American journal of human genetics. 2007 ; 80 (2) : 361-371. |
| PMID 17236141 |
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