A2M (alpha-2-macroglobulin)

Identity

Other names	CPAMD5
	DKFZp779B086
	FWP007
	S863-7
	alpha 2M
HGNC	A2M
Location	12p13.31
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	A2M   7
Entrez_Gene	A2M  2  alpha-2-macroglobulin
	Cards
GeneCards	A2M
Ensembl	A2M [Search_View]   ENSG00000121410 [Gene_View]
Genatlas	A2M
GeneLynx	A2M
eGenome	A2M
euGene	2
	Genomic and cartography
GoldenPath	A2M  -  12p13.31   chr12:9111571-9159825 -  12p13.31   [Description]    (hg18-March_2006)
Ensembl	A2M - 12p13.31 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	A2M
	Gene and transcription
Genbank	AB209614 [ ENTREZ ]
Genbank	AK307832 [ ENTREZ ]
Genbank	AK312482 [ ENTREZ ]
Genbank	AY591530 [ ENTREZ ]
Genbank	BC026246 [ ENTREZ ]
RefSeq	NM_000014 [ SRS ]    NM_000014 [ ENTREZ ]
RefSeq	AC_000055 [ SRS ]    AC_000055 [ ENTREZ ]
RefSeq	AC_000144 [ SRS ]    AC_000144 [ ENTREZ ]
RefSeq	NC_000012 [ SRS ]    NC_000012 [ ENTREZ ]
RefSeq	NT_009714 [ SRS ]    NT_009714 [ ENTREZ ]
RefSeq	NW_001838051 [ SRS ]    NW_001838051 [ ENTREZ ]
RefSeq	NW_925295 [ SRS ]    NW_925295 [ ENTREZ ]
AceView	A2M AceView - NCBI
Unigene	Hs.212838 [ SRS ]    Hs.212838 [ NCBI ]     HS212838 [ spliceNest ]
Fast-db	2203 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P01023 [ SRS]    P01023 [ EXPASY ]     P01023 [ INTERPRO ]     P01023 [ UNIPROT ]
Prosite	PS00477 ALPHA_2_MACROGLOBULIN [ SRS ]    PS00477 ALPHA_2_MACROGLOBULIN [ Expasy ]
Interpro	IPR009048 A-macroglobulin_rcpt-bd [ SRS ]    IPR009048 A-macroglobulin_rcpt-bd [ EBI ]
Interpro	IPR011626 A2M_comp [ SRS ]    IPR011626 A2M_comp [ EBI ]
Interpro	IPR002890 A2M_N [ SRS ]    IPR002890 A2M_N [ EBI ]
Interpro	IPR011625 A2M_N_2 [ SRS ]    IPR011625 A2M_N_2 [ EBI ]
Interpro	IPR001599 MacrogloblnA2 [ SRS ]    IPR001599 MacrogloblnA2 [ EBI ]
CluSTr	P01023
Pfam	PF00207 A2M [ SRS ]    PF00207 A2M [ Sanger ]    pfam00207 [ NCBI-CDD ]
Pfam	PF07678 A2M_comp [ SRS ]    PF07678 A2M_comp [ Sanger ]    pfam07678 [ NCBI-CDD ]
Pfam	PF01835 A2M_N [ SRS ]    PF01835 A2M_N [ Sanger ]    pfam01835 [ NCBI-CDD ]
Pfam	PF07703 A2M_N_2 [ SRS ]    PF07703 A2M_N_2 [ Sanger ]    pfam07703 [ NCBI-CDD ]
Pfam	PF07677 A2M_recep [ SRS ]    PF07677 A2M_recep [ Sanger ]    pfam07677 [ NCBI-CDD ]
Blocks	P01023
PDB	1BV8 [ SRS ]    1BV8 [ PdbSum ],   1BV8 [ IMB ]   1BV8 [ RSDB ]
PDB	2P9R [ SRS ]    2P9R [ PdbSum ],   2P9R [ IMB ]   2P9R [ RSDB ]
HPRD	00072
	Protein Interaction databases
DIP	P01023
IntAct	P01023
	Polymorphism : SNP, mutations, diseases
OMIM	103950;104300    [ map ]
GENECLINICS	103950;104300
SNP	A2M [dbSNP-NCBI]
SNP	NM_000014 [SNP-NCI]
SNP	A2M [GeneSNPs - Utah]  A2M] [HGBASE - SRS]
HAPMAP	A2M [HAPMAP]
HGMD	A2M
	General knowledge
Family Browser	A2M [UCSC Family Browser]
SOURCE	NM_000014
SMD	Hs.212838
SAGE	Hs.212838
GO	serine-type endopeptidase inhibitor activity [Amigo]  serine-type endopeptidase inhibitor activity
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	response to nutrient [Amigo]  response to nutrient
GO	response to carbon dioxide [Amigo]  response to carbon dioxide
GO	wide-spectrum protease inhibitor activity [Amigo]  wide-spectrum protease inhibitor activity
GO	enzyme binding [Amigo]  enzyme binding
GO	interleukin-8 binding [Amigo]  interleukin-8 binding
GO	interleukin-1 binding [Amigo]  interleukin-1 binding
GO	platelet alpha granule lumen [Amigo]  platelet alpha granule lumen
GO	tumor necrosis factor binding [Amigo]  tumor necrosis factor binding
GO	protein homooligomerization [Amigo]  protein homooligomerization
GO	response to glucocorticoid stimulus [Amigo]  response to glucocorticoid stimulus
PubGene	A2M
TreeFam	A2M
CTD	2 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	A2M Related clones (RZPD - Berlin)
	PubMed
PubMed	123 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 19:58:21 2008