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ACE2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2)

Identity

Other namesACEH
DKFZp434A014
HGNC (Hugo) ACE2
Location Xp22.2
Location_base_pair Starts at 15489077 and ends at 15530113 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ACE2   13557
Entrez_Gene (NCBI)ACE2  59272  angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Cards
GeneCards (Weizmann)ACE2
Ensembl (Hinxton)ENSG00000130234 [Gene_View]  ACE2 [Vega]
AceView (NCBI)ACE2
Genatlas (Paris)ACE2
euGene (Indiana)59272
SOURCE (Stanford)NM_021804
Gene Expression (Array Express) ENSG00000130234
Genomic and cartography
GoldenPath (UCSC)ACE2  -  Xp22.2   chrX:15489077-15530113 -  Xp22.2   [Description]    (hg18-March_2006)
EnsemblACE2 - Xp22.2 [CytoView]
Mapping of homologs : NCBIACE2 [Mapview]
OMIM300335   
Gene and transcription
Gene : Genbank (Entrez)AB046569 AB193259 AB193260 AF241254 AF291820
Reference sequence (RefSeq transcript) :SRSNM_021804
Reference transcript : EntrezNM_021804
RefSeq genomic : SRSAC_000066 AC_000155 NC_000023 NG_012575 NT_167197 NW_001842360 NW_927700
RefSeq genomic : EntrezAC_000066 AC_000155 NC_000023 NG_012575 NT_167197 NW_001842360 NW_927700
Consensus coding sequences : CCDS NCBIACE2
Cluster EST : UnigeneHs.178098 [ SRS ] Hs.178098 [ NCBI ]
Alternative Splicing : Fast-db (Paris)2405
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ9BYF1 (SRS) Q9BYF1 (Expasy) Q9BYF1 (Uniprot)
With graphics : InterProQ9BYF1
Splice isoforms : VarSplice FASTAQ9BYF1(VarSplice FASTA)
Domaine pattern : Prosite (SRS)ZINC_PROTEASE (PS00142)   
Domain pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (SRS)Peptidase_M2   
Domains : Interpro (EBI)Peptidase_M2   
Related proteins : CluSTrQ9BYF1
Domain families : Pfam SRSPeptidase_M2 (PF01401)   
Domain families : Pfam SangerPeptidase_M2 (PF01401)   
Domain families : Pfam NCBIpfam01401   
Blocks (Seattle)Q9BYF1
Crystal structure of protein : PDB SRS1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I   
Crystal structure of protein : PDBSum1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I   
Crystal structure of protein : IMB1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I   
Crystal structure of protein : PDB RSDB1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I   
HPRD02274
Protein Interaction databases
DIP (DOE-UCLA)Q9BYF1
IntAct (EBI)Q9BYF1
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIACE2
SNP : GeneSNP UtahACE2
SNP : HGBaseACE2
Genetic variants : HAPMAPACE2
Somatic Mutations in Cancer : COSMICACE2 
Mutations and Diseases : HGMDACE2
Hereditary diseases : OMIM300335   
Hereditary diseases : GENETests300335   
Diseases : Genetic AssociationACE2
General knowledge
Homologs : HomoloGeneACE2
Homology/Alignments : Family Browser UCSCACE2
Phylogenetic Trees/Animal Genes : TreeFamACE2
Catalytic activity : Enzyme3.4.17.- [ Enzyme-Expasy ]   3.4.17.- [ Enzyme-SRS ]   3.4.17.- [ IntEnz-EBI ]   3.4.17.- [ BRENDA ]   3.4.17.- [ KEGG ]   
Chemical/Protein Interactions : CTD59272
Keywords Ontology : AmiGOviral receptor activity  regulation of cytokine production  glycoprotein binding  angiotensin catabolic process in blood  angiotensin-mediated drinking behavior  regulation of systemic arterial blood pressure by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  carboxypeptidase activity  extracellular region  extracellular space  plasma membrane  proteolysis  oxygen and reactive oxygen species metabolic process  peptidase activity  metallopeptidase activity  peptidyl-dipeptidase activity  zinc ion binding  cell surface  integral to membrane  regulation of vasoconstriction  chloride ion binding  receptor biosynthetic process  regulation of cell proliferation  regulation of vasodilation  interspecies interaction between organisms  membrane raft  entry of virus into host cell  virion attachment, binding of host cell surface receptor  metal ion binding  regulation of inflammatory response  
Keywords Ontology : EGO-EBIviral receptor activity  regulation of cytokine production  glycoprotein binding  angiotensin catabolic process in blood  angiotensin-mediated drinking behavior  regulation of systemic arterial blood pressure by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  carboxypeptidase activity  extracellular region  extracellular space  plasma membrane  proteolysis  oxygen and reactive oxygen species metabolic process  peptidase activity  metallopeptidase activity  peptidyl-dipeptidase activity  zinc ion binding  cell surface  integral to membrane  regulation of vasoconstriction  chloride ion binding  receptor biosynthetic process  regulation of cell proliferation  regulation of vasodilation  interspecies interaction between organisms  membrane raft  entry of virus into host cell  virion attachment, binding of host cell surface receptor  metal ion binding  regulation of inflammatory response  
Pathways : BIOCARTAAngiotensin-converting enzyme 2 regulates heart function [Genes]   
Pathways : KEGG
Other databases
Probes
Probes : ImagenesACE2 Related clones (RZPD - Berlin)
Literature
PubMed108 Pubmed reference(s) in Entrez
PubGeneACE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:31:48 CET 2010
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