ACVR2B (activin A receptor, type IIB)

Identity

Other names	ACTRIIB
	ActR-IIB
	MGC116908
HGNC	ACVR2B
Location	3p22
Location_base_pair	Starts at 38470794 and ends at 38509637 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ACVR2B   174
Entrez_Gene	ACVR2B  93  activin A receptor, type IIB
	Cards
GeneCards	ACVR2B
Ensembl	ENSG00000114739 [Gene_View]  ACVR2B [Vega]
Genatlas	ACVR2B
	Genomic and cartography
GoldenPath	ACVR2B  -  3p22   chr3:38470794-38509637 +  3p22.2   [Description]    (hg18-March_2006)
Ensembl	ACVR2B - 3p22.2 [CytoView]
NCBI	Mapview
OMIM	602730 Disease map [OMIM]
HomoloGene	ACVR2B
	Gene and transcription
Genbank	AB209449 [ ENTREZ ]
Genbank	AF075005 [ ENTREZ ]
Genbank	BC096243 [ ENTREZ ]
Genbank	BC096244 [ ENTREZ ]
Genbank	BC096245 [ ENTREZ ]
RefSeq	NM_001106 [ SRS ]    NM_001106 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	AC_000135 [ SRS ]    AC_000135 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_022517 [ SRS ]    NT_022517 [ ENTREZ ]
RefSeq	NW_001838877 [ SRS ]    NW_001838877 [ ENTREZ ]
RefSeq	NW_921651 [ SRS ]    NW_921651 [ ENTREZ ]
CCDS	ACVR2B CCDS - NCBI
AceView	ACVR2B AceView - NCBI
Unigene	Hs.174273 [ SRS ]    Hs.174273 [ NCBI ]
Fast-db	4248 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q13705 [ SRS]    Q13705 [ EXPASY ]     Q13705 [ INTERPRO ]     Q13705 [ UNIPROT ] Q13705 [ VarSplice FASTA ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000333 Activin_II_recpt [ SRS ]    IPR000333 Activin_II_recpt [ EBI ]
Interpro	IPR015768 Activin_II_recpt_C [ SRS ]    IPR015768 Activin_II_recpt_C [ EBI ]
Interpro	IPR000472 Activin_rcpt [ SRS ]    IPR000472 Activin_rcpt [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
CluSTr	Q13705
Pfam	PF01064 Activin_recp [ SRS ]    PF01064 Activin_recp [ Sanger ]    pfam01064 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q13705 AVR2B_HUMAN [ Domain structure ]   Q13705 AVR2B_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q13705
PDB	2H62 [ SRS ]    2H62 [ PdbSum ],   2H62 [ IMB ]   2H62 [ RSDB ]
HPRD	04106
	Protein Interaction databases
DIP	Q13705
IntAct	Q13705
	Polymorphism : SNP, mutations, diseases
OMIM	602730    [ map ]
GENETests	602730
SNP	ACVR2B [dbSNP-NCBI]
SNP	NM_001106 [SNP-NCI]
SNP	ACVR2B [GeneSNPs - Utah]  ACVR2B] [HGBASE - SRS]
HAPMAP	ACVR2B [HAPMAP]
COSMIC	ACVR2B [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ACVR2B
Genetic Association	ACVR2B
CDC HuGE	ACVR2B
	General knowledge
Family Browser	ACVR2B [UCSC Family Browser]
SOURCE	NM_001106
SMD	Hs.174273
SAGE	Hs.174273
Enzyme	2.7.11.30 [ Enzyme-Expasy ]   2.7.11.30 [ Enzyme-SRS ]   2.7.11.30 [ IntEnz-EBI ]   2.7.11.30 [ BRENDA ]   2.7.11.30 [ KEGG ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	receptor activity [Amigo]  receptor activity
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	plasma membrane [Amigo]  plasma membrane
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	signal transduction [Amigo]  signal transduction
GO	anterior/posterior pattern formation [Amigo]  anterior/posterior pattern formation
GO	cell surface [Amigo]  cell surface
GO	activin receptor activity, type II [Amigo]  activin receptor activity, type II
GO	transferase activity [Amigo]  transferase activity
GO	growth factor binding [Amigo]  growth factor binding
GO	manganese ion binding [Amigo]  manganese ion binding
GO	positive regulation of bone mineralization [Amigo]  positive regulation of bone mineralization
GO	BMP signaling pathway [Amigo]  BMP signaling pathway
GO	BMP signaling pathway [Amigo]  BMP signaling pathway
GO	positive regulation of activin receptor signaling pathway [Amigo]  positive regulation of activin receptor signaling pathway
GO	regulation of transcription [Amigo]  regulation of transcription
GO	positive regulation of osteoblast differentiation [Amigo]  positive regulation of osteoblast differentiation
KEGG	Cytokine-cytokine receptor interaction
KEGG	TGF-beta signaling pathway
PubGene	ACVR2B
TreeFam	ACVR2B
CTD	93 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ACVR2B Related clones (RZPD - Berlin)
	PubMed
PubMed	35 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 13:32:31 2008