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ADAM10 (ADAM metallopeptidase domain 10)

Identity

Other namesAD10
CD156c
HsT18717
MADM
kuz
HGNC (Hugo) ADAM10
Location 15q22.1
Location_base_pair Starts at 56675802 and ends at 56829469 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADAM10   188
Entrez_Gene (NCBI)ADAM10  102  ADAM metallopeptidase domain 10
Cards
GeneCards (Weizmann)ADAM10
Ensembl (Hinxton)ENSG00000137845 [Gene_View]  ADAM10 [Vega]
AceView (NCBI)ADAM10
Genatlas (Paris)ADAM10
euGene (Indiana)102
SOURCE (Stanford)NM_001110
Gene Expression (Array Express) ENSG00000137845
Genomic and cartography
GoldenPath (UCSC)ADAM10  -  15q22.1   chr15:56675802-56829469 -  15q22.1   [Description]    (hg18-March_2006)
EnsemblADAM10 - 15q22.1 [CytoView]
Mapping of homologs : NCBIADAM10 [Mapview]
OMIM602192   
Gene and transcription
Gene : Genbank (Entrez)AF009615 AK023460 AK300472 BC055087 BC104659
Reference sequence (RefSeq transcript) :SRSNM_001110
Reference transcript : EntrezNM_001110
RefSeq genomic : SRSAC_000058 AC_000147 NC_000015 NT_010194 NW_001838218 NW_925884
RefSeq genomic : EntrezAC_000058 AC_000147 NC_000015 NT_010194 NW_001838218 NW_925884
Consensus coding sequences : CCDS NCBIADAM10
Cluster EST : UnigeneHs.578508 [ SRS ] Hs.578508 [ NCBI ]
Alternative Splicing : Fast-db (Paris)5950
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtO14672 (SRS) O14672 (Expasy) O14672 (Uniprot)
With graphics : InterProO14672
Splice isoforms : VarSplice FASTAO14672(VarSplice FASTA)
Domaine pattern : Prosite (SRS)ADAM_MEPRO (PS50215)    CYSTEINE_SWITCH (PS00546)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    ZINC_PROTEASE (PS00142)   
Domain pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    CYSTEINE_SWITCH (PS00546)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (SRS)Blood-coag_inhib_Disintegrin    Peptidase_M12B    Peptidase_M12B_N   
Domains : Interpro (EBI)Blood-coag_inhib_Disintegrin    Peptidase_M12B    Peptidase_M12B_N   
Related proteins : CluSTrO14672
Domain families : Pfam SRSDisintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam SangerDisintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam NCBIpfam00200    pfam01562    pfam01421   
Domain families : Smart EMBLDISIN (SM00050)  
Blocks (Seattle)O14672
Crystal structure of protein : PDB SRS1M1I   
Crystal structure of protein : PDBSum1M1I   
Crystal structure of protein : IMB1M1I   
Crystal structure of protein : PDB RSDB1M1I   
HPRD03723
Protein Interaction databases
DIP (DOE-UCLA)O14672
IntAct (EBI)O14672
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIADAM10
SNP : GeneSNP UtahADAM10
SNP : HGBaseADAM10
Genetic variants : HAPMAPADAM10
Somatic Mutations in Cancer : COSMICADAM10 
Mutations and Diseases : HGMDADAM10
Hereditary diseases : OMIM602192   
Hereditary diseases : GENETests602192   
Diseases : Genetic AssociationADAM10
General knowledge
Homologs : HomoloGeneADAM10
Homology/Alignments : Family Browser UCSCADAM10
Phylogenetic Trees/Animal Genes : TreeFamADAM10
Catalytic activity : Enzyme3.4.24.81 [ Enzyme-Expasy ]   3.4.24.81 [ Enzyme-SRS ]   3.4.24.81 [ IntEnz-EBI ]   3.4.24.81 [ BRENDA ]   3.4.24.81 [ KEGG ]   
Chemical/Protein Interactions : CTD102
Keywords Ontology : AmiGOin utero embryonic development  metalloendopeptidase activity  integrin binding  nucleus  cytoplasm  Golgi apparatus  Golgi-associated vesicle  plasma membrane  protein amino acid phosphorylation  proteolysis  negative regulation of cell adhesion  negative regulation of cell adhesion  Notch signaling pathway  integrin-mediated signaling pathway  cell-cell signaling  peptidase activity  zinc ion binding  positive regulation of cell proliferation  cell surface  positive regulation of T cell chemotaxis  postsynaptic density  integral to membrane  SH3 domain binding  protein kinase binding  positive regulation of cell growth  positive regulation of cell migration  response to tumor necrosis factor  monocyte activation  protein homodimerization activity  metal ion binding  PMA-inducible membrane protein ectodomain proteolysis  constitutive protein ectodomain proteolysis  
Keywords Ontology : EGO-EBIin utero embryonic development  metalloendopeptidase activity  integrin binding  nucleus  cytoplasm  Golgi apparatus  Golgi-associated vesicle  plasma membrane  protein amino acid phosphorylation  proteolysis  negative regulation of cell adhesion  negative regulation of cell adhesion  Notch signaling pathway  integrin-mediated signaling pathway  cell-cell signaling  peptidase activity  zinc ion binding  positive regulation of cell proliferation  cell surface  positive regulation of T cell chemotaxis  postsynaptic density  integral to membrane  SH3 domain binding  protein kinase binding  positive regulation of cell growth  positive regulation of cell migration  response to tumor necrosis factor  monocyte activation  protein homodimerization activity  metal ion binding  PMA-inducible membrane protein ectodomain proteolysis  constitutive protein ectodomain proteolysis  
Pathways : BIOCARTAGeneration of amyloid b-peptide by PS1 [Genes]   
Pathways : KEGGEpithelial cell signaling in Helicobacter pylori infection
Other databases
Probes
Probes : ImagenesADAM10 Related clones (RZPD - Berlin)
Literature
PubMed100 Pubmed reference(s) in Entrez
PubGeneADAM10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

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indexed on : Sat Feb 27 10:40:21 CET 2010
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