ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif, 12)

Identity

Other names	PRO4389
HGNC	ADAMTS12
Location	5q35
Location_base_pair	Starts at 33563044 and ends at 33927881 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ADAMTS12   14605
Entrez_Gene	ADAMTS12  81792  ADAM metallopeptidase with thrombospondin type 1 motif, 12
	Cards
GeneCards	ADAMTS12
Ensembl	ENSG00000151388 [Gene_View]  ADAMTS12 [Vega]
Genatlas	ADAMTS12
	Genomic and cartography
GoldenPath	ADAMTS12  -  5q35   chr5:33563044-33927881 -  5p13.3   [Description]    (hg18-March_2006)
Ensembl	ADAMTS12 - 5p13.3 [CytoView]
NCBI	Mapview
OMIM	606184 Disease map [OMIM]
HomoloGene	ADAMTS12
	Gene and transcription
Genbank	AJ250725 [ ENTREZ ]
Genbank	AW938686 [ ENTREZ ]
Genbank	AY358745 [ ENTREZ ]
Genbank	BC058841 [ ENTREZ ]
Genbank	BC131733 [ ENTREZ ]
RefSeq	NM_030955 [ SRS ]    NM_030955 [ ENTREZ ]
RefSeq	AC_000048 [ SRS ]    AC_000048 [ ENTREZ ]
RefSeq	AC_000137 [ SRS ]    AC_000137 [ ENTREZ ]
RefSeq	NC_000005 [ SRS ]    NC_000005 [ ENTREZ ]
RefSeq	NT_006576 [ SRS ]    NT_006576 [ ENTREZ ]
RefSeq	NW_001838929 [ SRS ]    NW_001838929 [ ENTREZ ]
RefSeq	NW_922562 [ SRS ]    NW_922562 [ ENTREZ ]
CCDS	ADAMTS12 CCDS - NCBI
AceView	ADAMTS12 AceView - NCBI
Unigene	Hs.12680 [ SRS ]    Hs.12680 [ NCBI ]
Fast-db	2242 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P58397 [ SRS]    P58397 [ EXPASY ]     P58397 [ INTERPRO ]     P58397 [ UNIPROT ] P58397 [ VarSplice FASTA ]
Prosite	PS50215 ADAM_MEPRO [ SRS ]    PS50215 ADAM_MEPRO [ Expasy ]
Prosite	PS00546 CYSTEINE_SWITCH [ SRS ]    PS00546 CYSTEINE_SWITCH [ Expasy ]
Prosite	PS00427 DISINTEGRIN_1 [ SRS ]    PS00427 DISINTEGRIN_1 [ Expasy ]
Prosite	PS50214 DISINTEGRIN_2 [ SRS ]    PS50214 DISINTEGRIN_2 [ Expasy ]
Prosite	PS50900 PLAC [ SRS ]    PS50900 PLAC [ Expasy ]
Prosite	PS50092 TSP1 [ SRS ]    PS50092 TSP1 [ Expasy ]
Prosite	PS00142 ZINC_PROTEASE [ SRS ]    PS00142 ZINC_PROTEASE [ Expasy ]
Interpro	IPR010294 ADAM_spacer1 [ SRS ]    IPR010294 ADAM_spacer1 [ EBI ]
Interpro	IPR001762 Blood-coag_inhib_Disintegrin [ SRS ]    IPR001762 Blood-coag_inhib_Disintegrin [ EBI ]
Interpro	IPR001818 Pept_M10A_M12B [ SRS ]    IPR001818 Pept_M10A_M12B [ EBI ]
Interpro	IPR006025 Pept_M_Zn_BS [ SRS ]    IPR006025 Pept_M_Zn_BS [ EBI ]
Interpro	IPR001590 Peptidase_M12B [ SRS ]    IPR001590 Peptidase_M12B [ EBI ]
Interpro	IPR013273 Peptidase_M12B_ADAM-TS [ SRS ]    IPR013273 Peptidase_M12B_ADAM-TS [ EBI ]
Interpro	IPR002870 Peptidase_M12B_N [ SRS ]    IPR002870 Peptidase_M12B_N [ EBI ]
Interpro	IPR010909 PLAC [ SRS ]    IPR010909 PLAC [ EBI ]
Interpro	IPR000884 TSP1 [ SRS ]    IPR000884 TSP1 [ EBI ]
Interpro	IPR008085 TSP_1 [ SRS ]    IPR008085 TSP_1 [ EBI ]
CluSTr	P58397
Pfam	PF05986 ADAM_spacer1 [ SRS ]    PF05986 ADAM_spacer1 [ Sanger ]    pfam05986 [ NCBI-CDD ]
Pfam	PF01562 Pep_M12B_propep [ SRS ]    PF01562 Pep_M12B_propep [ Sanger ]    pfam01562 [ NCBI-CDD ]
Pfam	PF01421 Reprolysin [ SRS ]    PF01421 Reprolysin [ Sanger ]    pfam01421 [ NCBI-CDD ]
Pfam	PF00090 TSP_1 [ SRS ]    PF00090 TSP_1 [ Sanger ]    pfam00090 [ NCBI-CDD ]
Smart	SM00209 TSP1 [EMBL]
Blocks	P58397
HPRD	05862
	Protein Interaction databases
DIP	P58397
IntAct	P58397
	Polymorphism : SNP, mutations, diseases
OMIM	606184    [ map ]
GENETests	606184
SNP	ADAMTS12 [dbSNP-NCBI]
SNP	NM_030955 [SNP-NCI]
SNP	ADAMTS12 [GeneSNPs - Utah]  ADAMTS12] [HGBASE - SRS]
HAPMAP	ADAMTS12 [HAPMAP]
COSMIC	ADAMTS12 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ADAMTS12
Genetic Association	ADAMTS12
CDC HuGE	ADAMTS12
	General knowledge
Family Browser	ADAMTS12 [UCSC Family Browser]
SOURCE	NM_030955
SMD	Hs.12680
SAGE	Hs.12680
Enzyme	3.4.24.- [ Enzyme-Expasy ]   3.4.24.- [ Enzyme-SRS ]   3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]
GO	metalloendopeptidase activity [Amigo]  metalloendopeptidase activity
GO	extracellular region [Amigo]  extracellular region
GO	proteinaceous extracellular matrix [Amigo]  proteinaceous extracellular matrix
GO	proteolysis [Amigo]  proteolysis
GO	zinc ion binding [Amigo]  zinc ion binding
GO	metal ion binding [Amigo]  metal ion binding
PubGene	ADAMTS12
TreeFam	ADAMTS12
CTD	81792 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ADAMTS12 Related clones (RZPD - Berlin)
	PubMed
PubMed	9 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 13:32:41 2008