AKAP8 (A-kinase anchoring protein 8)

2003-11-01  

Identity

HGNC
AKAP8
LOCATION
19p13.12
LOCUSID
10270
ALIAS
AKAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10270
MIM: 604692
HGNC: 378
Ensembl: ENSG00000105127

Variants:

dbSNP: 10270
ClinVar: 10270
TCGA: ENSG00000105127
COSMIC: AKAP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105127ENST00000269701O43823
ENSG00000105127ENST00000598597M0QYL4
ENSG00000105127ENST00000599883M0QX51

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
239957572013Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.24
127403812003Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication.23
162275972005A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association.16
124148072002AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.11
260763562015Reciprocal Relationship between Head Size, an Autism Endophenotype, and Gene Dosage at 19p13.12 Points to AKAP8 and AKAP8L.7
257702152015Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in Its Dissociation from Chromatin and the Nuclear Matrix.6
268237472015Roles of Cx43 and AKAP95 in ovarian cancer tissues in G1/S phase.5
278240342016AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors.4
283797802017AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint.3
266838272016A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.2

Citation

Dessen P

AKAP8 (A-kinase anchoring protein 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/609/akap8