AKR1C2 (aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III))

Identity

Other names	AKR1C-pseudo
	BABP
	DD
	DD2
	DDH2
	HAKRD
	HBAB
	MCDR2
HGNC	AKR1C2
Location	10p15-p14
Location_base_pair	Starts at 5021965 and ends at 5050207 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	AKR1C2   385
Entrez_Gene	AKR1C2  1646  aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
	Cards
GeneCards	AKR1C2
Ensembl	ENSG00000151632 [Gene_View]  AKR1C2 [Vega]
Genatlas	AKR1C2
	Genomic and cartography
GoldenPath	AKR1C2  -     chr10:5021965-5050207 -  10p15.1   [Description]    (hg18-March_2006)
Ensembl	AKR1C2 - 10p15.1 [CytoView]
NCBI	Mapview
OMIM	600450 Disease map [OMIM]
HomoloGene	AKR1C2
	Gene and transcription
Genbank	AB021654 [ ENTREZ ]
Genbank	AB031084 [ ENTREZ ]
Genbank	AB209017 [ ENTREZ ]
Genbank	AK091194 [ ENTREZ ]
Genbank	AK290304 [ ENTREZ ]
RefSeq	NM_001354 [ SRS ]    NM_001354 [ ENTREZ ]
RefSeq	NM_205845 [ SRS ]    NM_205845 [ ENTREZ ]
RefSeq	AC_000142 [ SRS ]    AC_000142 [ ENTREZ ]
RefSeq	NC_000010 [ SRS ]    NC_000010 [ ENTREZ ]
RefSeq	NT_077567 [ SRS ]    NT_077567 [ ENTREZ ]
RefSeq	NW_001837930 [ SRS ]    NW_001837930 [ ENTREZ ]
CCDS	AKR1C2 CCDS - NCBI
AceView	AKR1C2 AceView - NCBI
Unigene	Hs.567256 [ SRS ]    Hs.567256 [ NCBI ]
Fast-db	530 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P52895 [ SRS]    P52895 [ EXPASY ]     P52895 [ INTERPRO ]     P52895 [ UNIPROT ] P52895 [ VarSplice FASTA ]
Prosite	PS00798 ALDOKETO_REDUCTASE_1 [ SRS ]    PS00798 ALDOKETO_REDUCTASE_1 [ Expasy ]
Prosite	PS00062 ALDOKETO_REDUCTASE_2 [ SRS ]    PS00062 ALDOKETO_REDUCTASE_2 [ Expasy ]
Prosite	PS00063 ALDOKETO_REDUCTASE_3 [ SRS ]    PS00063 ALDOKETO_REDUCTASE_3 [ Expasy ]
Interpro	IPR001395 Aldo/ket_red [ SRS ]    IPR001395 Aldo/ket_red [ EBI ]
CluSTr	P52895
Pfam	PF00248 Aldo_ket_red [ SRS ]    PF00248 Aldo_ket_red [ Sanger ]    pfam00248 [ NCBI-CDD ]
Prodom	PD000288 Aldo/ket_red[INRA-Toulouse]
Prodom	P52895 AK1C2_HUMAN [ Domain structure ]   P52895 AK1C2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P52895
PDB	1IHI [ SRS ]    1IHI [ PdbSum ],   1IHI [ IMB ]   1IHI [ RSDB ]
PDB	1J96 [ SRS ]    1J96 [ PdbSum ],   1J96 [ IMB ]   1J96 [ RSDB ]
PDB	1XJB [ SRS ]    1XJB [ PdbSum ],   1XJB [ IMB ]   1XJB [ RSDB ]
PDB	2HDJ [ SRS ]    2HDJ [ PdbSum ],   2HDJ [ IMB ]   2HDJ [ RSDB ]
PDB	2IPJ [ SRS ]    2IPJ [ PdbSum ],   2IPJ [ IMB ]   2IPJ [ RSDB ]
HPRD	11857
	Protein Interaction databases
DIP	P52895
IntAct	P52895
	Polymorphism : SNP, mutations, diseases
OMIM	600450    [ map ]
GENETests	600450
SNP	AKR1C2 [dbSNP-NCBI]
SNP	NM_001354 [SNP-NCI]
SNP	NM_205845 [SNP-NCI]
SNP	AKR1C2 [GeneSNPs - Utah]  AKR1C2] [HGBASE - SRS]
HAPMAP	AKR1C2 [HAPMAP]
HGMD	AKR1C2
Genetic Association	AKR1C2
CDC HuGE	AKR1C2
	General knowledge
Family Browser	AKR1C2 [UCSC Family Browser]
SOURCE	NM_001354
SOURCE	NM_205845
SMD	Hs.567256
SAGE	Hs.567256
Enzyme	1.-.-.- [ Enzyme-Expasy ]   1.-.-.- [ Enzyme-SRS ]   1.-.-.- [ IntEnz-EBI ]   1.-.-.- [ BRENDA ]   1.-.-.- [ KEGG ]
GO	cytoplasm [Amigo]  cytoplasm
GO	lipid metabolic process [Amigo]  lipid metabolic process
GO	prostaglandin metabolic process [Amigo]  prostaglandin metabolic process
GO	digestion [Amigo]  digestion
GO	steroid metabolic process [Amigo]  steroid metabolic process
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	bile acid binding [Amigo]  bile acid binding
GO	3-alpha-hydroxysteroid dehydrogenase (A-specific) activity [Amigo]  3-alpha-hydroxysteroid dehydrogenase (A-specific) activity
GO	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [Amigo]  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO	oxidation reduction [Amigo]  oxidation reduction
KEGG	Metabolism of xenobiotics by cytochrome P450
PubGene	AKR1C2
TreeFam	AKR1C2
CTD	1646 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	AKR1C2 Related clones (RZPD - Berlin)
	PubMed
PubMed	31 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 13:33:28 2008