APEX1 (APEX nuclease (multifunctional DNA repair enzyme) 1)

Identity

Other names	APE
	APE-1
	APE1
	APEN
	APEX
	APX
	HAP1
	REF-1
	REF1
HGNC	APEX1
Location	14q11.2
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	APEX1   587
Entrez_Gene	APEX1  328  APEX nuclease (multifunctional DNA repair enzyme) 1
	Cards
GeneCards	APEX1
Ensembl	APEX1 [Search_View]   ENSG00000100823 [Gene_View]
Genatlas	APEX1
GeneLynx	APEX1
eGenome	APEX1
euGene	328
	Genomic and cartography
GoldenPath	APEX1  -  14q11.2   chr14:19993130-19995766 +  14q11.2   [Description]    (hg18-March_2006)
Ensembl	APEX1 - 14q11.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	APEX1
	Gene and transcription
Genbank	AK098588 [ ENTREZ ]
Genbank	AK291100 [ ENTREZ ]
Genbank	BC002338 [ ENTREZ ]
Genbank	BC004979 [ ENTREZ ]
Genbank	BC008145 [ ENTREZ ]
RefSeq	NM_001641 [ SRS ]    NM_001641 [ ENTREZ ]
RefSeq	NM_080648 [ SRS ]    NM_080648 [ ENTREZ ]
RefSeq	NM_080649 [ SRS ]    NM_080649 [ ENTREZ ]
RefSeq	AC_000057 [ SRS ]    AC_000057 [ ENTREZ ]
RefSeq	AC_000146 [ SRS ]    AC_000146 [ ENTREZ ]
RefSeq	NC_000014 [ SRS ]    NC_000014 [ ENTREZ ]
RefSeq	NT_026437 [ SRS ]    NT_026437 [ ENTREZ ]
RefSeq	NW_001838110 [ SRS ]    NW_001838110 [ ENTREZ ]
RefSeq	NW_925539 [ SRS ]    NW_925539 [ ENTREZ ]
AceView	APEX1 AceView - NCBI
Unigene	Hs.73722 [ SRS ]    Hs.73722 [ NCBI ]     HS73722 [ spliceNest ]
Fast-db	16 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P27695 [ SRS]    P27695 [ EXPASY ]     P27695 [ INTERPRO ]     P27695 [ UNIPROT ]
Prosite	PS00726 AP_NUCLEASE_F1_1 [ SRS ]    PS00726 AP_NUCLEASE_F1_1 [ Expasy ]
Prosite	PS00727 AP_NUCLEASE_F1_2 [ SRS ]    PS00727 AP_NUCLEASE_F1_2 [ Expasy ]
Prosite	PS00728 AP_NUCLEASE_F1_3 [ SRS ]    PS00728 AP_NUCLEASE_F1_3 [ Expasy ]
Interpro	IPR000097 AP_endonuc_F1 [ SRS ]    IPR000097 AP_endonuc_F1 [ EBI ]
Interpro	IPR005135 Endo/exonuclease/phosphatase [ SRS ]    IPR005135 Endo/exonuclease/phosphatase [ EBI ]
Interpro	IPR004808 exoDNase_III [ SRS ]    IPR004808 exoDNase_III [ EBI ]
CluSTr	P27695
Pfam	PF03372 Exo_endo_phos [ SRS ]    PF03372 Exo_endo_phos [ Sanger ]    pfam03372 [ NCBI-CDD ]
Blocks	P27695
PDB	1BIX [ SRS ]    1BIX [ PdbSum ],   1BIX [ IMB ]   1BIX [ RSDB ]
PDB	1CQG [ SRS ]    1CQG [ PdbSum ],   1CQG [ IMB ]   1CQG [ RSDB ]
PDB	1CQH [ SRS ]    1CQH [ PdbSum ],   1CQH [ IMB ]   1CQH [ RSDB ]
PDB	1DE8 [ SRS ]    1DE8 [ PdbSum ],   1DE8 [ IMB ]   1DE8 [ RSDB ]
PDB	1DE9 [ SRS ]    1DE9 [ PdbSum ],   1DE9 [ IMB ]   1DE9 [ RSDB ]
PDB	1DEW [ SRS ]    1DEW [ PdbSum ],   1DEW [ IMB ]   1DEW [ RSDB ]
PDB	1E9N [ SRS ]    1E9N [ PdbSum ],   1E9N [ IMB ]   1E9N [ RSDB ]
PDB	1HD7 [ SRS ]    1HD7 [ PdbSum ],   1HD7 [ IMB ]   1HD7 [ RSDB ]
PDB	2ISI [ SRS ]    2ISI [ PdbSum ],   2ISI [ IMB ]   2ISI [ RSDB ]
PDB	2O3H [ SRS ]    2O3H [ PdbSum ],   2O3H [ IMB ]   2O3H [ RSDB ]
HPRD	00136
	Protein Interaction databases
DIP	P27695
IntAct	P27695
	Polymorphism : SNP, mutations, diseases
OMIM	107748    [ map ]
GENECLINICS	107748
SNP	APEX1 [dbSNP-NCBI]
SNP	NM_001641 [SNP-NCI]
SNP	NM_080648 [SNP-NCI]
SNP	NM_080649 [SNP-NCI]
SNP	APEX1 [GeneSNPs - Utah]  APEX1] [HGBASE - SRS]
HAPMAP	APEX1 [HAPMAP]
COSMIC	APEX1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	APEX1
	General knowledge
Family Browser	APEX1 [UCSC Family Browser]
SOURCE	NM_001641
SOURCE	NM_080648
SOURCE	NM_080649
SMD	Hs.73722
SAGE	Hs.73722
Enzyme	4.2.99.18 [ Enzyme-Expasy ]   4.2.99.18 [ Enzyme-SRS ]   4.2.99.18 [ IntEnz-EBI ]   4.2.99.18 [ BRENDA ]   4.2.99.18 [ KEGG ]   4.2.99.18 [ WIT ]
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	DNA binding [Amigo]  DNA binding
GO	transcription coactivator activity [Amigo]  transcription coactivator activity
GO	transcription corepressor activity [Amigo]  transcription corepressor activity
GO	DNA-(apurinic or apyrimidinic site) lyase activity [Amigo]  DNA-(apurinic or apyrimidinic site) lyase activity
GO	endodeoxyribonuclease activity [Amigo]  endodeoxyribonuclease activity
GO	ribonuclease H activity [Amigo]  ribonuclease H activity
GO	phosphodiesterase I activity [Amigo]  phosphodiesterase I activity
GO	uracil DNA N-glycosylase activity [Amigo]  uracil DNA N-glycosylase activity
GO	protein binding [Amigo]  protein binding
GO	intracellular [Amigo]  intracellular
GO	nucleus [Amigo]  nucleus
GO	nucleoplasm [Amigo]  nucleoplasm
GO	cytoplasm [Amigo]  cytoplasm
GO	endoplasmic reticulum [Amigo]  endoplasmic reticulum
GO	ribosome [Amigo]  ribosome
GO	base-excision repair [Amigo]  base-excision repair
GO	transcription from RNA polymerase II promoter [Amigo]  transcription from RNA polymerase II promoter
GO	3'-5' exonuclease activity [Amigo]  3'-5' exonuclease activity
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	lyase activity [Amigo]  lyase activity
GO	regulation of cell redox homeostasis [Amigo]  regulation of cell redox homeostasis
GO	perinuclear region of cytoplasm [Amigo]  perinuclear region of cytoplasm
GO	regulation of DNA binding [Amigo]  regulation of DNA binding
BIOCARTA	Granzyme A mediated Apoptosis Pathway    [Genes]
PubGene	APEX1
TreeFam	APEX1
CTD	328 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	APEX1 Related clones (RZPD - Berlin)
	PubMed
PubMed	186 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:00:26 2008