APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2)

2003-12-01  

Identity

HGNC
APEX2
LOCATION
Xp11.21
LOCUSID
27301
ALIAS
APE2,APEXL2,XTH2,ZGRF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27301
MIM: 300773
HGNC: 17889
Ensembl: ENSG00000169188

Variants:

dbSNP: 27301
ClinVar: 27301
TCGA: ENSG00000169188
COSMIC: APEX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169188ENST00000374987Q9UBZ4
ENSG00000169188ENST00000374987E5KN95

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
BER complexKEGGhsa_M00296
BER complexKEGGM00296

References

Pubmed IDYearTitleCitations
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
118665372002Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III.45
166876562006Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs.43
194434502009Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage.32
306865912019Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.16
205225372010Variation within DNA repair pathway genes and risk of multiple sclerosis.11
301108972018Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2.8
308056132019Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system.3
318283262020APE1 senses DNA single-strand breaks for repair and signaling.2

Citation

Dessen P

APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/670/apex2