APP (amyloid beta (A4) precursor protein)

Identity

Other names	AAA
	ABETA
	ABPP
	AD1
	APPI
	CTFgamma
	CVAP
	PN2
HGNC	APP
Location	21q21.2
Location_base_pair	Starts at 26174732 and ends at 26465003 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	APP   620
Entrez_Gene	APP  351  amyloid beta (A4) precursor protein
	Cards
GeneCards	APP
Ensembl	APP [Search_View]   ENSG00000142192 [Gene_View]
Genatlas	APP
GeneLynx	APP
eGenome	APP
euGene	351
	Genomic and cartography
GoldenPath	APP  -  21q21.2   chr21:26174732-26465003 -  21q21.3   [Description]    (hg18-March_2006)
Ensembl	APP - 21q21.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	APP
	Gene and transcription
Genbank	A02759 [ ENTREZ ]
Genbank	AB066441 [ ENTREZ ]
Genbank	AF282245 [ ENTREZ ]
Genbank	AK311717 [ ENTREZ ]
Genbank	AK312326 [ ENTREZ ]
RefSeq	NM_000484 [ SRS ]    NM_000484 [ ENTREZ ]
RefSeq	NM_201413 [ SRS ]    NM_201413 [ ENTREZ ]
RefSeq	NM_201414 [ SRS ]    NM_201414 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	AC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NG_007376 [ SRS ]    NG_007376 [ ENTREZ ]
RefSeq	NT_011512 [ SRS ]    NT_011512 [ ENTREZ ]
RefSeq	NW_001838706 [ SRS ]    NW_001838706 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
AceView	APP AceView - NCBI
Unigene	Hs.434980 [ SRS ]    Hs.434980 [ NCBI ]     HS434980 [ spliceNest ]
Fast-db	1321 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P05067 [ SRS]    P05067 [ EXPASY ]     P05067 [ INTERPRO ]     P05067 [ UNIPROT ]
Prosite	PS00319 A4_EXTRA [ SRS ]    PS00319 A4_EXTRA [ Expasy ]
Prosite	PS00320 A4_INTRA [ SRS ]    PS00320 A4_INTRA [ Expasy ]
Prosite	PS00280 BPTI_KUNITZ_1 [ SRS ]    PS00280 BPTI_KUNITZ_1 [ Expasy ]
Prosite	PS50279 BPTI_KUNITZ_2 [ SRS ]    PS50279 BPTI_KUNITZ_2 [ Expasy ]
Interpro	IPR013803 Amyloid_glyco_Abeta [ SRS ]    IPR013803 Amyloid_glyco_Abeta [ EBI ]
Interpro	IPR008155 Amyloid_glyco_core [ SRS ]    IPR008155 Amyloid_glyco_core [ EBI ]
Interpro	IPR011178 Amyloid_glyco_Cu-bd [ SRS ]    IPR011178 Amyloid_glyco_Cu-bd [ EBI ]
Interpro	IPR008154 Amyloid_glyco_extra [ SRS ]    IPR008154 Amyloid_glyco_extra [ EBI ]
Interpro	IPR015849 Amyloid_glyco_heparin-bd [ SRS ]    IPR015849 Amyloid_glyco_heparin-bd [ EBI ]
Interpro	IPR002223 Prot_inh_Kunz-m [ SRS ]    IPR002223 Prot_inh_Kunz-m [ EBI ]
CluSTr	P05067
Pfam	PF02177 A4_EXTRA [ SRS ]    PF02177 A4_EXTRA [ Sanger ]    pfam02177 [ NCBI-CDD ]
Pfam	PF03494 Beta-APP [ SRS ]    PF03494 Beta-APP [ Sanger ]    pfam03494 [ NCBI-CDD ]
Pfam	PF00014 Kunitz_BPTI [ SRS ]    PF00014 Kunitz_BPTI [ Sanger ]    pfam00014 [ NCBI-CDD ]
Smart	SM00006 A4_EXTRA [EMBL]
Smart	SM00131 KU [EMBL]
Prodom	PD000222 Prot_Inh_Kunz-m[INRA-Toulouse]
Prodom	P05067 A4_HUMAN [ Domain structure ]   P05067 A4_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P05067
PDB	1AAP [ SRS ]    1AAP [ PdbSum ],   1AAP [ IMB ]   1AAP [ RSDB ]
PDB	1AMB [ SRS ]    1AMB [ PdbSum ],   1AMB [ IMB ]   1AMB [ RSDB ]
PDB	1AMC [ SRS ]    1AMC [ PdbSum ],   1AMC [ IMB ]   1AMC [ RSDB ]
PDB	1AML [ SRS ]    1AML [ PdbSum ],   1AML [ IMB ]   1AML [ RSDB ]
PDB	1BA4 [ SRS ]    1BA4 [ PdbSum ],   1BA4 [ IMB ]   1BA4 [ RSDB ]
PDB	1BA6 [ SRS ]    1BA6 [ PdbSum ],   1BA6 [ IMB ]   1BA6 [ RSDB ]
PDB	1BJB [ SRS ]    1BJB [ PdbSum ],   1BJB [ IMB ]   1BJB [ RSDB ]
PDB	1BJC [ SRS ]    1BJC [ PdbSum ],   1BJC [ IMB ]   1BJC [ RSDB ]
PDB	1BRC [ SRS ]    1BRC [ PdbSum ],   1BRC [ IMB ]   1BRC [ RSDB ]
PDB	1CA0 [ SRS ]    1CA0 [ PdbSum ],   1CA0 [ IMB ]   1CA0 [ RSDB ]
PDB	1HZ3 [ SRS ]    1HZ3 [ PdbSum ],   1HZ3 [ IMB ]   1HZ3 [ RSDB ]
PDB	1IYT [ SRS ]    1IYT [ PdbSum ],   1IYT [ IMB ]   1IYT [ RSDB ]
PDB	1MWP [ SRS ]    1MWP [ PdbSum ],   1MWP [ IMB ]   1MWP [ RSDB ]
PDB	1OWT [ SRS ]    1OWT [ PdbSum ],   1OWT [ IMB ]   1OWT [ RSDB ]
PDB	1QCM [ SRS ]    1QCM [ PdbSum ],   1QCM [ IMB ]   1QCM [ RSDB ]
PDB	1QWP [ SRS ]    1QWP [ PdbSum ],   1QWP [ IMB ]   1QWP [ RSDB ]
PDB	1QXC [ SRS ]    1QXC [ PdbSum ],   1QXC [ IMB ]   1QXC [ RSDB ]
PDB	1QYT [ SRS ]    1QYT [ PdbSum ],   1QYT [ IMB ]   1QYT [ RSDB ]
PDB	1RW6 [ SRS ]    1RW6 [ PdbSum ],   1RW6 [ IMB ]   1RW6 [ RSDB ]
PDB	1TAW [ SRS ]    1TAW [ PdbSum ],   1TAW [ IMB ]   1TAW [ RSDB ]
PDB	1TKN [ SRS ]    1TKN [ PdbSum ],   1TKN [ IMB ]   1TKN [ RSDB ]
PDB	1UO7 [ SRS ]    1UO7 [ PdbSum ],   1UO7 [ IMB ]   1UO7 [ RSDB ]
PDB	1UO8 [ SRS ]    1UO8 [ PdbSum ],   1UO8 [ IMB ]   1UO8 [ RSDB ]
PDB	1UOA [ SRS ]    1UOA [ PdbSum ],   1UOA [ IMB ]   1UOA [ RSDB ]
PDB	1UOI [ SRS ]    1UOI [ PdbSum ],   1UOI [ IMB ]   1UOI [ RSDB ]
PDB	1ZE7 [ SRS ]    1ZE7 [ PdbSum ],   1ZE7 [ IMB ]   1ZE7 [ RSDB ]
PDB	1ZE9 [ SRS ]    1ZE9 [ PdbSum ],   1ZE9 [ IMB ]   1ZE9 [ RSDB ]
PDB	1ZJD [ SRS ]    1ZJD [ PdbSum ],   1ZJD [ IMB ]   1ZJD [ RSDB ]
PDB	2BEG [ SRS ]    2BEG [ PdbSum ],   2BEG [ IMB ]   2BEG [ RSDB ]
PDB	2BOM [ SRS ]    2BOM [ PdbSum ],   2BOM [ IMB ]   2BOM [ RSDB ]
PDB	2BP4 [ SRS ]    2BP4 [ PdbSum ],   2BP4 [ IMB ]   2BP4 [ RSDB ]
PDB	2FJZ [ SRS ]    2FJZ [ PdbSum ],   2FJZ [ IMB ]   2FJZ [ RSDB ]
PDB	2FK1 [ SRS ]    2FK1 [ PdbSum ],   2FK1 [ IMB ]   2FK1 [ RSDB ]
PDB	2FK2 [ SRS ]    2FK2 [ PdbSum ],   2FK2 [ IMB ]   2FK2 [ RSDB ]
PDB	2FK3 [ SRS ]    2FK3 [ PdbSum ],   2FK3 [ IMB ]   2FK3 [ RSDB ]
PDB	2FKL [ SRS ]    2FKL [ PdbSum ],   2FKL [ IMB ]   2FKL [ RSDB ]
PDB	2FMA [ SRS ]    2FMA [ PdbSum ],   2FMA [ IMB ]   2FMA [ RSDB ]
PDB	2IPU [ SRS ]    2IPU [ PdbSum ],   2IPU [ IMB ]   2IPU [ RSDB ]
PDB	2OTK [ SRS ]    2OTK [ PdbSum ],   2OTK [ IMB ]   2OTK [ RSDB ]
HPRD	00100
	Protein Interaction databases
DIP	P05067
IntAct	P05067
	Polymorphism : SNP, mutations, diseases
OMIM	104760;605714    [ map ]
GENECLINICS	104760;605714
SNP	APP [dbSNP-NCBI]
SNP	NM_000484 [SNP-NCI]
SNP	NM_201413 [SNP-NCI]
SNP	NM_201414 [SNP-NCI]
SNP	APP [GeneSNPs - Utah]  APP] [HGBASE - SRS]
HAPMAP	APP [HAPMAP]
HGMD	APP
	General knowledge
Family Browser	APP [UCSC Family Browser]
SOURCE	NM_000484
SOURCE	NM_201413
SOURCE	NM_201414
SMD	Hs.434980
SAGE	Hs.434980
GO	serine-type endopeptidase inhibitor activity [Amigo]  serine-type endopeptidase inhibitor activity
GO	serine-type endopeptidase inhibitor activity [Amigo]  serine-type endopeptidase inhibitor activity
GO	iron ion binding [Amigo]  iron ion binding
GO	copper ion binding [Amigo]  copper ion binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	coated pit [Amigo]  coated pit
GO	cellular copper ion homeostasis [Amigo]  cellular copper ion homeostasis
GO	endocytosis [Amigo]  endocytosis
GO	apoptosis [Amigo]  apoptosis
GO	cell adhesion [Amigo]  cell adhesion
GO	Notch signaling pathway [Amigo]  Notch signaling pathway
GO	heparin binding [Amigo]  heparin binding
GO	zinc ion binding [Amigo]  zinc ion binding
GO	cell surface [Amigo]  cell surface
GO	membrane [Amigo]  membrane
GO	platelet alpha granule lumen [Amigo]  platelet alpha granule lumen
GO	acetylcholine receptor binding [Amigo]  acetylcholine receptor binding
GO	identical protein binding [Amigo]  identical protein binding
GO	metal ion binding [Amigo]  metal ion binding
GO	neuromuscular process [Amigo]  neuromuscular process
BIOCARTA	Generation of amyloid b-peptide by PS1    [Genes]
BIOCARTA	Deregulation of CDK5 in Alzheimers Disease    [Genes]
BIOCARTA	Platelet Amyloid Precursor Protein Pathway    [Genes]
KEGG	Neurodegenerative Disorders
KEGG	Alzheimer's disease
PubGene	APP
TreeFam	APP
CTD	351 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	APP Related clones (RZPD - Berlin)
	PubMed
PubMed	499 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:30:51 2008