ARHGAP1 (Rho GTPase activating protein 1)

2003-02-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
CDC42GAP,RHOGAP,RHOGAP1,p50rhoGAP
FUSION GENES

Other Information

Locus ID:

NCBI: 392
MIM: 602732
HGNC: 673
Ensembl: ENSG00000175220

Variants:

dbSNP: 392
ClinVar: 392
TCGA: ENSG00000175220
COSMIC: ARHGAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175220ENST00000311956Q07960
ENSG00000175220ENST00000525488E9PNR6
ENSG00000175220ENST00000528837H0YE29

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
147245722004Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.58
190662812009DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling.34
152629742004Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil.29
191036062009Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP.23
236846082013RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain.19
232009242013ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells.18
231756282013Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas.16
240863032013The human minor histocompatibility antigen 1 is a RhoGAP.12
125011932002Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis.11
287485342017miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.8

Citation

Dessen P

ARHGAP1 (Rho GTPase activating protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/694/arhgap1