ARHGAP17 (Rho GTPase activating protein 17)

2006-10-01  

Identity

HGNC
LOCATION
16p12.1
LOCUSID
ALIAS
MST066,MST110,MSTP038,MSTP066,MSTP110,NADRIN,PP367,PP4534,RICH-1,RICH1,WBP15
FUSION GENES

Other Information

Locus ID:

NCBI: 55114
MIM: 608293
HGNC: 18239
Ensembl: ENSG00000140750

Variants:

dbSNP: 55114
ClinVar: 55114
TCGA: ENSG00000140750
COSMIC: ARHGAP17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140750ENST00000289968Q68EM7
ENSG00000140750ENST00000303665Q68EM7
ENSG00000140750ENST00000455311C9IZD3
ENSG00000140750ENST00000571406I3L3P1
ENSG00000140750ENST00000571480I3L1S9
ENSG00000140750ENST00000571843I3L4Y5
ENSG00000140750ENST00000573449I3L4P6
ENSG00000140750ENST00000573625I3L4P0
ENSG00000140750ENST00000573765I3L460

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166780972006A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.147
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
260041352015Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway.8
265076612015Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.7
306412182019ARHGAP17 suppresses tumor progression and up-regulates P21 and P27 expression via inhibiting PI3K/AKT signaling pathway in cervical cancer.6
299717822018Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network.4
297306552018Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/β-Catenin Signaling.2

Citation

Dessen P

ARHGAP17 (Rho GTPase activating protein 17)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43134/arhgap17