ARHGEF10L (Rho guanine nucleotide exchange factor 10 like)

2003-05-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
GrinchGEF
FUSION GENES

Other Information

Locus ID:

NCBI: 55160
MIM: 612494
HGNC: 25540
Ensembl: ENSG00000074964

Variants:

dbSNP: 55160
ClinVar: 55160
TCGA: ENSG00000074964
COSMIC: ARHGEF10L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074964ENST00000167825A0A384DVK7
ENSG00000074964ENST00000361221Q9HCE6
ENSG00000074964ENST00000375408Q5VXI4
ENSG00000074964ENST00000375415Q9HCE6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
188499932008Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.47
161120812005GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor.9
299797932018Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.6
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.5
304449692019ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.3

Citation

Dessen P

ARHGEF10L (Rho guanine nucleotide exchange factor 10 like)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40584/arhgef10l