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ARHGEF7 (Rho guanine nucleotide exchange factor (GEF) 7)

Identity

Other namesBETA-PIX
COOL1
DKFZp686C12170
DKFZp761K1021
KIAA0142
KIAA0412
Nbla10314
P50
P50BP
P85
P85COOL1
P85SPR
PAK3
PIXB
HGNC (Hugo) ARHGEF7
Location 13q34
Location_base_pair Starts at 110565625 and ends at 110745543 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ARHGEF7   15607
Entrez_Gene (NCBI)ARHGEF7  8874  Rho guanine nucleotide exchange factor (GEF) 7
Cards
GeneCards (Weizmann)ARHGEF7
Ensembl (Hinxton)ENSG00000102606 [Gene_View]  ARHGEF7 [Vega]
AceView (NCBI)ARHGEF7
Genatlas (Paris)ARHGEF7
euGene (Indiana)8874
SOURCE (Stanford)NM_001113511 NM_001113512 NM_001113513 NM_003899 NM_145735
Gene Expression (Array Express) ENSG00000102606
Genomic and cartography
GoldenPath (UCSC)ARHGEF7  -  13q34   chr13:110565625-110745543 +  13q34   [Description]    (hg18-March_2006)
EnsemblARHGEF7 - 13q34 [CytoView]
Mapping of homologs : NCBIARHGEF7 [Mapview]
OMIM605477   
Gene and transcription
Gene : Genbank (Entrez)AA457036 AB075521 AB177848 AB177849 AJ844629
Reference sequence (RefSeq transcript) :SRSNM_001113511 NM_001113512 NM_001113513 NM_003899 NM_145735
Reference transcript : EntrezNM_001113511 NM_001113512 NM_001113513 NM_003899 NM_145735
RefSeq genomic : SRSAC_000056 AC_000145 NC_000013 NT_009952 NW_001838084 NW_925517
RefSeq genomic : EntrezAC_000056 AC_000145 NC_000013 NT_009952 NW_001838084 NW_925517
Consensus coding sequences : CCDS NCBIARHGEF7
Cluster EST : UnigeneHs.508738 [ SRS ] Hs.508738 [ NCBI ]
Alternative Splicing : Fast-db (Paris)9191
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ14155 (SRS) Q14155 (Expasy) Q14155 (Uniprot)
With graphics : InterProQ14155
Splice isoforms : VarSplice FASTAQ14155(VarSplice FASTA)
Domaine pattern : Prosite (SRS)CH (PS50021)    DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)    SH3 (PS50002)   
Domain pattern : Prosite (Expaxy)CH (PS50021)    DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)    SH3 (PS50002)   
Domains : Interpro (SRS)Calponin-homology    Calponin_act_bd    DH-domain    GDS_CDC24_CS    Pleckstrin_homology    SH3_2    SH3_domain    SH3_region   
Domains : Interpro (EBI)Calponin-homology    Calponin_act_bd    DH-domain    GDS_CDC24_CS    Pleckstrin_homology    SH3_2    SH3_domain    SH3_region   
Related proteins : CluSTrQ14155
Domain families : Pfam SRSCH (PF00307)    PH (PF00169)    RhoGEF (PF00621)    SH3_2 (PF07653)   
Domain families : Pfam SangerCH (PF00307)    PH (PF00169)    RhoGEF (PF00621)    SH3_2 (PF07653)   
Domain families : Pfam NCBIpfam00307    pfam00169    pfam00621    pfam07653   
Domain families : Smart EMBLCH (SM00033)  PH (SM00233)  RhoGEF (SM00325)  SH3 (SM00326)  
Blocks (Seattle)Q14155
Crystal structure of protein : PDB SRS1BY1    1ZSG   
Crystal structure of protein : PDBSum1BY1    1ZSG   
Crystal structure of protein : IMB1BY1    1ZSG   
Crystal structure of protein : PDB RSDB1BY1    1ZSG   
HPRD05688
Protein Interaction databases
DIP (DOE-UCLA)Q14155
IntAct (EBI)Q14155
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIARHGEF7
SNP : GeneSNP UtahARHGEF7
SNP : HGBaseARHGEF7
Genetic variants : HAPMAPARHGEF7
Somatic Mutations in Cancer : COSMICARHGEF7 
Mutations and Diseases : HGMDARHGEF7
Hereditary diseases : OMIM605477   
Hereditary diseases : GENETests605477   
Diseases : Genetic AssociationARHGEF7
General knowledge
Homologs : HomoloGeneARHGEF7
Homology/Alignments : Family Browser UCSCARHGEF7
Phylogenetic Trees/Animal Genes : TreeFamARHGEF7
Chemical/Protein Interactions : CTD8874
Keywords Ontology : AmiGOguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  intracellular  cytoplasm  cytosol  focal adhesion  small GTPase mediated signal transduction  induction of apoptosis by extracellular signals  growth cone  regulation of Rho protein signal transduction  positive regulation of apoptosis  astrocyte cell migration  
Keywords Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  intracellular  cytoplasm  cytosol  focal adhesion  small GTPase mediated signal transduction  induction of apoptosis by extracellular signals  growth cone  regulation of Rho protein signal transduction  positive regulation of apoptosis  astrocyte cell migration  
Pathways : BIOCARTA
Pathways : KEGGRegulation of actin cytoskeleton
Other databases
Probes
Probes : ImagenesARHGEF7 Related clones (RZPD - Berlin)
Literature
PubMed60 Pubmed reference(s) in Entrez
PubGeneARHGEF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:36:29 CET 2010
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