AURKA (aurora kinase A)

Identity

Other names	AIK
	ARK1
	AURA
	AURORA2
	BTAK
	MGC34538
	STK15
	STK6
	STK7
Hugo	AURKA
Location	20q13.2-q13.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	AURKA
GDB	AURKA
Entrez_Gene	AURKA  6790  aurora kinase A
	Cards
GeneCards	AURKA
Ensembl	AURKA [Search_View]   ENSG00000087586 [Gene_View]
Genatlas	AURKA
GeneLynx	AURKA
eGenome	AURKA
euGene	6790
	Genomic and cartography
GoldenPath	AURKA  -     chr20:54377852-54400758 -  20q13.2   [Description]    (hg18-March_2006)
Ensembl	AURKA - 20q13.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	AURKA
	Gene and transcription
Genbank	AF008551 [ ENTREZ ]
Genbank	AF011468 [ ENTREZ ]
Genbank	AL711075 [ ENTREZ ]
Genbank	AM392948 [ ENTREZ ]
Genbank	BC001280 [ ENTREZ ]
RefSeq	NM_003600 [ SRS ]    NM_003600 [ ENTREZ ]
RefSeq	NM_198433 [ SRS ]    NM_198433 [ ENTREZ ]
RefSeq	NM_198434 [ SRS ]    NM_198434 [ ENTREZ ]
RefSeq	NM_198435 [ SRS ]    NM_198435 [ ENTREZ ]
RefSeq	NM_198436 [ SRS ]    NM_198436 [ ENTREZ ]
RefSeq	NM_198437 [ SRS ]    NM_198437 [ ENTREZ ]
RefSeq	AC_000063 [ SRS ]    AC_000063 [ ENTREZ ]
RefSeq	NC_000020 [ SRS ]    NC_000020 [ ENTREZ ]
RefSeq	NT_011362 [ SRS ]    NT_011362 [ ENTREZ ]
RefSeq	NW_927339 [ SRS ]    NW_927339 [ ENTREZ ]
AceView	AURKA AceView - NCBI
Unigene	Hs.250822 [ SRS ]    Hs.250822 [ NCBI ]     HS250822 [ spliceNest ]
Fast-db	13689 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O14965 [ SRS]    O14965 [ EXPASY ]     O14965 [ INTERPRO ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	O14965
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	O14965 STK6_HUMAN [ Domain structure ]   O14965 STK6_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O14965
PDB	1MQ4 [ SRS ]    1MQ4 [ PdbSum ],   1MQ4 [ IMB ]   1MQ4 [ RSDB ]
PDB	1MUO [ SRS ]    1MUO [ PdbSum ],   1MUO [ IMB ]   1MUO [ RSDB ]
PDB	1OL5 [ SRS ]    1OL5 [ PdbSum ],   1OL5 [ IMB ]   1OL5 [ RSDB ]
PDB	1OL6 [ SRS ]    1OL6 [ PdbSum ],   1OL6 [ IMB ]   1OL6 [ RSDB ]
PDB	1OL7 [ SRS ]    1OL7 [ PdbSum ],   1OL7 [ IMB ]   1OL7 [ RSDB ]
PDB	2BMC [ SRS ]    2BMC [ PdbSum ],   2BMC [ IMB ]   2BMC [ RSDB ]
PDB	2C6D [ SRS ]    2C6D [ PdbSum ],   2C6D [ IMB ]   2C6D [ RSDB ]
PDB	2C6E [ SRS ]    2C6E [ PdbSum ],   2C6E [ IMB ]   2C6E [ RSDB ]
PDB	2DWB [ SRS ]    2DWB [ PdbSum ],   2DWB [ IMB ]   2DWB [ RSDB ]
PDB	2J4Z [ SRS ]    2J4Z [ PdbSum ],   2J4Z [ IMB ]   2J4Z [ RSDB ]
PDB	2J50 [ SRS ]    2J50 [ PdbSum ],   2J50 [ IMB ]   2J50 [ RSDB ]
PDB	2NP8 [ SRS ]    2NP8 [ PdbSum ],   2NP8 [ IMB ]   2NP8 [ RSDB ]
HPRD	04066
	Protein Interaction databases
DIP	O14965
IntAct	O14965
	Polymorphism : SNP, mutations, diseases
OMIM	114500;603072    [ map ]
GENECLINICS	114500;603072
SNP	AURKA [dbSNP-NCBI]
SNP	NM_003600 [SNP-NCI]
SNP	NM_198433 [SNP-NCI]
SNP	NM_198434 [SNP-NCI]
SNP	NM_198435 [SNP-NCI]
SNP	NM_198436 [SNP-NCI]
SNP	NM_198437 [SNP-NCI]
SNP	AURKA [GeneSNPs - Utah]  AURKA] [HGBASE - SRS]
HAPMAP	AURKA [HAPMAP]
COSMIC	AURKA [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	AURKA
	General knowledge
Family Browser	AURKA [UCSC Family Browser]
SOURCE	NM_003600
SOURCE	NM_198433
SOURCE	NM_198434
SOURCE	NM_198435
SOURCE	NM_198436
SOURCE	NM_198437
SMD	Hs.250822
SAGE	Hs.250822
Enzyme	2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ Brenda-SRS ]   2.7.11.1 [ KEGG ]   2.7.11.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	protein kinase activity [Amigo]  protein kinase activity
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	protein binding [Amigo]  protein binding
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	nucleus [Amigo]  nucleus
GO	centrosome [Amigo]  centrosome
GO	spindle [Amigo]  spindle
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	cell cycle [Amigo]  cell cycle
GO	spindle organization and biogenesis [Amigo]  spindle organization and biogenesis
GO	mitosis [Amigo]  mitosis
GO	kinase activity [Amigo]  kinase activity
GO	transferase activity [Amigo]  transferase activity
GO	regulation of protein stability [Amigo]  regulation of protein stability
GO	phosphoinositide-mediated signaling [Amigo]  phosphoinositide-mediated signaling
BIOCARTA	Role of Ran in mitotic spindle regulation    [Genes]
PubGene	AURKA
TreeFam	AURKA
CTD	6790 [Comparative Genomics Database]
	Other databases
	Probes
Probe	AURKA Related clones (RZPD - Berlin)
	PubMed
PubMed	121 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 19:57:08 2008