AXIN1 (axin 1)

Identity

Other names	AXIN
	MGC52315
HGNC	AXIN1
Location	16p13.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	AXIN1   903
Entrez_Gene	AXIN1  8312  axin 1
	Cards
GeneCards	AXIN1
Ensembl	AXIN1 [Search_View]   ENSG00000103126 [Gene_View]
Genatlas	AXIN1
GeneLynx	AXIN1
eGenome	AXIN1
euGene	8312
	Genomic and cartography
GoldenPath	AXIN1  -  16p13.3   chr16:277441-342465 -  16p13.3   [Description]    (hg18-March_2006)
Ensembl	AXIN1 - 16p13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	AXIN1
	Gene and transcription
Genbank	AB208876 [ ENTREZ ]
Genbank	AF009674 [ ENTREZ ]
Genbank	BC017447 [ ENTREZ ]
Genbank	BC035872 [ ENTREZ ]
Genbank	BC044648 [ ENTREZ ]
RefSeq	NM_003502 [ SRS ]    NM_003502 [ ENTREZ ]
RefSeq	NM_181050 [ SRS ]    NM_181050 [ ENTREZ ]
RefSeq	AC_000059 [ SRS ]    AC_000059 [ ENTREZ ]
RefSeq	AC_000148 [ SRS ]    AC_000148 [ ENTREZ ]
RefSeq	NC_000016 [ SRS ]    NC_000016 [ ENTREZ ]
RefSeq	NT_037887 [ SRS ]    NT_037887 [ ENTREZ ]
RefSeq	NW_001838339 [ SRS ]    NW_001838339 [ ENTREZ ]
RefSeq	NW_926018 [ SRS ]    NW_926018 [ ENTREZ ]
AceView	AXIN1 AceView - NCBI
Unigene	Hs.592082 [ SRS ]    Hs.592082 [ NCBI ]     HS592082 [ spliceNest ]
Fast-db	419 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O15169 [ SRS]    O15169 [ EXPASY ]     O15169 [ INTERPRO ]     O15169 [ UNIPROT ]
Prosite	PS50841 DIX [ SRS ]    PS50841 DIX [ Expasy ]
Prosite	PS50132 RGS [ SRS ]    PS50132 RGS [ Expasy ]
Interpro	IPR014936 Axin_b-cat_bd [ SRS ]    IPR014936 Axin_b-cat_bd [ EBI ]
Interpro	IPR001158 DIX [ SRS ]    IPR001158 DIX [ EBI ]
Interpro	IPR000342 Regulat_G_prot_signal [ SRS ]    IPR000342 Regulat_G_prot_signal [ EBI ]
CluSTr	O15169
Pfam	PF08833 Axin_b-cat_bind [ SRS ]    PF08833 Axin_b-cat_bind [ Sanger ]    pfam08833 [ NCBI-CDD ]
Pfam	PF00778 DIX [ SRS ]    PF00778 DIX [ Sanger ]    pfam00778 [ NCBI-CDD ]
Pfam	PF00615 RGS [ SRS ]    PF00615 RGS [ Sanger ]    pfam00615 [ NCBI-CDD ]
Smart	SM00021 DAX [EMBL]
Smart	SM00315 RGS [EMBL]
Prodom	PD003639 DIX[INRA-Toulouse]
Prodom	O15169 AXN1_HUMAN [ Domain structure ]   O15169 AXN1_HUMAN  [ sequences sharing at least 1 domain ]
Prodom	PD003639[INRA-Toulouse]
Prodom	O15169 AXN1_HUMAN [ Domain structure ]   O15169 AXN1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O15169
PDB	1DK8 [ SRS ]    1DK8 [ PdbSum ],   1DK8 [ IMB ]   1DK8 [ RSDB ]
PDB	1EMU [ SRS ]    1EMU [ PdbSum ],   1EMU [ IMB ]   1EMU [ RSDB ]
HPRD	04819
	Protein Interaction databases
DIP	O15169
IntAct	O15169
	Polymorphism : SNP, mutations, diseases
OMIM	114550;603816;607864    [ map ]
GENECLINICS	114550;603816;607864
SNP	AXIN1 [dbSNP-NCBI]
SNP	NM_003502 [SNP-NCI]
SNP	NM_181050 [SNP-NCI]
SNP	AXIN1 [GeneSNPs - Utah]  AXIN1] [HGBASE - SRS]
HAPMAP	AXIN1 [HAPMAP]
COSMIC	AXIN1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	AXIN1
	General knowledge
Family Browser	AXIN1 [UCSC Family Browser]
SOURCE	NM_003502
SOURCE	NM_181050
SMD	Hs.592082
SAGE	Hs.592082
GO	signal transducer activity [Amigo]  signal transducer activity
GO	protein binding [Amigo]  protein binding
GO	intracellular [Amigo]  intracellular
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	apoptosis [Amigo]  apoptosis
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	oocyte axis determination [Amigo]  oocyte axis determination
GO	lateral plasma membrane [Amigo]  lateral plasma membrane
GO	beta-catenin destruction complex [Amigo]  beta-catenin destruction complex
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	negative regulation of cell cycle [Amigo]  negative regulation of cell cycle
GO	positive regulation of JNK cascade [Amigo]  positive regulation of JNK cascade
GO	Wnt receptor signaling pathway through beta-catenin [Amigo]  Wnt receptor signaling pathway through beta-catenin
BIOCARTA	ALK in cardiac myocytes    [Genes]
BIOCARTA	Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages    [Genes]
BIOCARTA	Multi-step Regulation of Transcription by Pitx2    [Genes]
BIOCARTA	Presenilin action in Notch and Wnt signaling    [Genes]
BIOCARTA	WNT Signaling Pathway    [Genes]
KEGG	Wnt signaling pathway
KEGG	Colorectal cancer
PubGene	AXIN1
TreeFam	AXIN1
CTD	8312 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	AXIN1 Related clones (RZPD - Berlin)
	PubMed
PubMed	76 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:01:26 2008