BACE2 (beta-site APP-cleaving enzyme 2)

Identity

Other names	AEPLC
	ALP56
	ASP1
	ASP21
	BAE2
	CDA13
	CEAP1
	DRAP
HGNC	BACE2
Location	21q22.3
Location_base_pair	Starts at 41461598 and ends at 41570394 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	BACE2   934
Entrez_Gene	BACE2  25825  beta-site APP-cleaving enzyme 2
	Cards
GeneCards	BACE2
Ensembl	BACE2 [Search_View]   ENSG00000182240 [Gene_View]
Genatlas	BACE2
GeneLynx	BACE2
eGenome	BACE2
euGene	25825
	Genomic and cartography
GoldenPath	BACE2  -  21q22.3   chr21:41461598-41570394 +  21q22.3   [Description]    (hg18-March_2006)
Ensembl	BACE2 - 21q22.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	BACE2
	Gene and transcription
Genbank	AF050171 [ ENTREZ ]
Genbank	AF117892 [ ENTREZ ]
Genbank	AF178532 [ ENTREZ ]
Genbank	AF188276 [ ENTREZ ]
Genbank	AF188277 [ ENTREZ ]
RefSeq	NM_012105 [ SRS ]    NM_012105 [ ENTREZ ]
RefSeq	NM_138991 [ SRS ]    NM_138991 [ ENTREZ ]
RefSeq	NM_138992 [ SRS ]    NM_138992 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	AC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NT_011512 [ SRS ]    NT_011512 [ ENTREZ ]
RefSeq	NW_001838710 [ SRS ]    NW_001838710 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
AceView	BACE2 AceView - NCBI
Unigene	Hs.529408 [ SRS ]    Hs.529408 [ NCBI ]     HS529408 [ spliceNest ]
Fast-db	3052 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q5DIH8 [ SRS]    Q5DIH8 [ EXPASY ]     Q5DIH8 [ INTERPRO ]     Q5DIH8 [ UNIPROT ]
CluSTr	Q5DIH8
Blocks	Q5DIH8
HPRD	05744
	Protein Interaction databases
DIP	Q5DIH8
IntAct	Q5DIH8
	Polymorphism : SNP, mutations, diseases
OMIM	605668    [ map ]
GENECLINICS	605668
SNP	BACE2 [dbSNP-NCBI]
SNP	NM_012105 [SNP-NCI]
SNP	NM_138991 [SNP-NCI]
SNP	NM_138992 [SNP-NCI]
SNP	BACE2 [GeneSNPs - Utah]  BACE2] [HGBASE - SRS]
HAPMAP	BACE2 [HAPMAP]
HGMD	BACE2
	General knowledge
Family Browser	BACE2 [UCSC Family Browser]
SOURCE	NM_012105
SOURCE	NM_138991
SOURCE	NM_138992
SMD	Hs.529408
SAGE	Hs.529408
GO	pepsin A activity [Amigo]  pepsin A activity
GO	membrane fraction [Amigo]  membrane fraction
GO	protein modification process [Amigo]  protein modification process
GO	proteolysis [Amigo]  proteolysis
GO	proteolysis [Amigo]  proteolysis
GO	membrane protein ectodomain proteolysis [Amigo]  membrane protein ectodomain proteolysis
GO	membrane protein ectodomain proteolysis [Amigo]  membrane protein ectodomain proteolysis
GO	peptidase activity [Amigo]  peptidase activity
GO	aspartic-type signal peptidase activity [Amigo]  aspartic-type signal peptidase activity
GO	protein secretion [Amigo]  protein secretion
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	peptide hormone processing [Amigo]  peptide hormone processing
GO	negative regulation of amyloid precursor protein biosynthetic process [Amigo]  negative regulation of amyloid precursor protein biosynthetic process
GO	negative regulation of amyloid precursor protein biosynthetic process [Amigo]  negative regulation of amyloid precursor protein biosynthetic process
KEGG	Alzheimer's disease
PubGene	BACE2
TreeFam	BACE2
CTD	25825 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	BACE2 Related clones (RZPD - Berlin)
	PubMed
PubMed	38 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:31:52 2008