BAIAP2 (BAR/IMD domain containing adaptor protein 2)

2010-07-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
BAP2,FLAF3,IRSP53,WAML
FUSION GENES

Other Information

Locus ID:

NCBI: 10458
MIM: 605475
HGNC: 947
Ensembl: ENSG00000175866

Variants:

dbSNP: 10458
ClinVar: 10458
TCGA: ENSG00000175866
COSMIC: BAIAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175866ENST00000321280Q9UQB8
ENSG00000175866ENST00000321300Q9UQB8
ENSG00000175866ENST00000416299B4DWA1
ENSG00000175866ENST00000428708Q9UQB8
ENSG00000175866ENST00000435091Q9UQB8
ENSG00000175866ENST00000571530I3L0M4
ENSG00000175866ENST00000572073I3L2M4
ENSG00000175866ENST00000572329I3L3J7
ENSG00000175866ENST00000572498I3L3C6
ENSG00000175866ENST00000572918I3L327
ENSG00000175866ENST00000573659I3L526
ENSG00000175866ENST00000573677I3L1C8
ENSG00000175866ENST00000574804I3L2J6
ENSG00000175866ENST00000575245I3L4C2
ENSG00000175866ENST00000575712Q9UQB8
ENSG00000175866ENST00000575750I3L3C5
ENSG00000175866ENST00000575841I3L4A3
ENSG00000175866ENST00000575958I3L125
ENSG00000175866ENST00000575989I3L113
ENSG00000175866ENST00000576756I3L0Y9

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Regulation of actin cytoskeletonKEGGko04810
Adherens junctionKEGGhsa04520
Regulation of actin cytoskeletonKEGGhsa04810
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
173718342007Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism.144
171150312006Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.97
156354472005Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53.91
147521062004A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.74
156736672005Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases.71
191939062009Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53.60
167022312006Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.55
170030442006The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation.54
192861342009IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.44
264692462015IRSp53 senses negative membrane curvature and phase separates along membrane tubules.39

Citation

Dessen P

BAIAP2 (BAR/IMD domain containing adaptor protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/gene/51548/baiap2