BCL2A1 (BCL2 related protein A1)

2003-02-01  

Identity

HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
ACC-1,ACC-2,ACC1,ACC2,BCL2L5,BFL1,GRS,HBPA1
FUSION GENES

Other Information

Locus ID:

NCBI: 597
MIM: 601056
HGNC: 991
Ensembl: ENSG00000140379

Variants:

dbSNP: 597
ClinVar: 597
TCGA: ENSG00000140379
COSMIC: BCL2A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140379ENST00000267953Q16548
ENSG00000140379ENST00000335661Q16548

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
234475652013BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition.82
119298712002Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax.47
127711802003Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens.41
126655762003NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1.32
165516342006The stability and anti-apoptotic function of A1 are controlled by its C terminus.30
188121742008Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.30
156175212005Anaplasma phagocytophilum inhibits human neutrophil apoptosis via upregulation of bfl-1, maintenance of mitochondrial membrane potential and prevention of caspase 3 activation.28
179427582008The dual effects of TNFalpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1.28
154996302005High expression of bfl-1 contributes to the apoptosis resistant phenotype in B-cell chronic lymphocytic leukemia.25

Citation

Dessen P

BCL2A1 (BCL2 related protein A1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/770/bcl2a1