BCL2L1 (BCL2-like 1)

Identity

Other names	BCL-XL/S
	BCL2L
	BCLX
	Bcl-X
	DKFZp781P2092
	bcl-xL
	bcl-xS
Hugo	BCL2L1
Location	20q11.21
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	BCL2L1
GDB	BCL2L1
Entrez_Gene	BCL2L1  598  BCL2-like 1
	Cards
GeneCards	BCL2L1
Ensembl	BCL2L1 [Search_View]   ENSG00000171552 [Gene_View]
Genatlas	BCL2L1
GeneLynx	BCL2L1
eGenome	BCL2L1
euGene	598
	Genomic and cartography
GoldenPath	BCL2L1  -  20q11.21   chr20:29715924-29774317 -  20q11.21   [Description]    (hg18-March_2006)
Ensembl	BCL2L1 - 20q11.21 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	BCL2L1
	Gene and transcription
Genbank	AK290968 [ ENTREZ ]
Genbank	AY263335 [ ENTREZ ]
Genbank	AY263336 [ ENTREZ ]
Genbank	BC019307 [ ENTREZ ]
Genbank	BT007208 [ ENTREZ ]
RefSeq	NM_001191 [ SRS ]    NM_001191 [ ENTREZ ]
RefSeq	NM_138578 [ SRS ]    NM_138578 [ ENTREZ ]
RefSeq	AC_000063 [ SRS ]    AC_000063 [ ENTREZ ]
RefSeq	NC_000020 [ SRS ]    NC_000020 [ ENTREZ ]
RefSeq	NT_028392 [ SRS ]    NT_028392 [ ENTREZ ]
RefSeq	NW_927339 [ SRS ]    NW_927339 [ ENTREZ ]
AceView	BCL2L1 AceView - NCBI
Unigene	Hs.516966 [ SRS ]    Hs.516966 [ NCBI ]     HS516966 [ spliceNest ]
Fast-db	7629 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q07817 [ SRS]    Q07817 [ EXPASY ]     Q07817 [ INTERPRO ]
Prosite	PS50062 BCL2_FAMILY [ SRS ]    PS50062 BCL2_FAMILY [ Expasy ]
Prosite	PS01080 BH1 [ SRS ]    PS01080 BH1 [ Expasy ]
Prosite	PS01258 BH2 [ SRS ]    PS01258 BH2 [ Expasy ]
Prosite	PS01259 BH3 [ SRS ]    PS01259 BH3 [ Expasy ]
Prosite	PS01260 BH4_1 [ SRS ]    PS01260 BH4_1 [ Expasy ]
Prosite	PS50063 BH4_2 [ SRS ]    PS50063 BH4_2 [ Expasy ]
Interpro	IPR013279 Apop_reg_BclX [ SRS ]    IPR013279 Apop_reg_BclX [ EBI ]
Interpro	IPR002475 BCL2_apoptsis [ SRS ]    IPR002475 BCL2_apoptsis [ EBI ]
Interpro	IPR000712 Bcl2_BH [ SRS ]    IPR000712 Bcl2_BH [ EBI ]
Interpro	IPR003093 Bcl2_BH4 [ SRS ]    IPR003093 Bcl2_BH4 [ EBI ]
Interpro	IPR004725 Bcl2_reg [ SRS ]    IPR004725 Bcl2_reg [ EBI ]
CluSTr	Q07817
Pfam	PF00452 Bcl-2 [ SRS ]    PF00452 Bcl-2 [ Sanger ]    pfam00452 [ NCBI-CDD ]
Pfam	PF02180 BH4 [ SRS ]    PF02180 BH4 [ Sanger ]    pfam02180 [ NCBI-CDD ]
Smart	SM00337 BCL [EMBL]
Smart	SM00265 BH4 [EMBL]
Blocks	Q07817
PDB	1BXL [ SRS ]    1BXL [ PdbSum ],   1BXL [ IMB ]   1BXL [ RSDB ]
PDB	1G5J [ SRS ]    1G5J [ PdbSum ],   1G5J [ IMB ]   1G5J [ RSDB ]
PDB	1LXL [ SRS ]    1LXL [ PdbSum ],   1LXL [ IMB ]   1LXL [ RSDB ]
PDB	1MAZ [ SRS ]    1MAZ [ PdbSum ],   1MAZ [ IMB ]   1MAZ [ RSDB ]
PDB	1R2D [ SRS ]    1R2D [ PdbSum ],   1R2D [ IMB ]   1R2D [ RSDB ]
PDB	1R2E [ SRS ]    1R2E [ PdbSum ],   1R2E [ IMB ]   1R2E [ RSDB ]
PDB	1R2G [ SRS ]    1R2G [ PdbSum ],   1R2G [ IMB ]   1R2G [ RSDB ]
PDB	1R2H [ SRS ]    1R2H [ PdbSum ],   1R2H [ IMB ]   1R2H [ RSDB ]
PDB	1R2I [ SRS ]    1R2I [ PdbSum ],   1R2I [ IMB ]   1R2I [ RSDB ]
PDB	1YSG [ SRS ]    1YSG [ PdbSum ],   1YSG [ IMB ]   1YSG [ RSDB ]
PDB	1YSI [ SRS ]    1YSI [ PdbSum ],   1YSI [ IMB ]   1YSI [ RSDB ]
PDB	1YSN [ SRS ]    1YSN [ PdbSum ],   1YSN [ IMB ]   1YSN [ RSDB ]
PDB	2B48 [ SRS ]    2B48 [ PdbSum ],   2B48 [ IMB ]   2B48 [ RSDB ]
PDB	2O1Y [ SRS ]    2O1Y [ PdbSum ],   2O1Y [ IMB ]   2O1Y [ RSDB ]
PDB	2O2M [ SRS ]    2O2M [ PdbSum ],   2O2M [ IMB ]   2O2M [ RSDB ]
PDB	2O2N [ SRS ]    2O2N [ PdbSum ],   2O2N [ IMB ]   2O2N [ RSDB ]
PDB	2P1L [ SRS ]    2P1L [ PdbSum ],   2P1L [ IMB ]   2P1L [ RSDB ]
PDB	2YXJ [ SRS ]    2YXJ [ PdbSum ],   2YXJ [ IMB ]   2YXJ [ RSDB ]
HPRD	02497
	Protein Interaction databases
DIP	Q07817
IntAct	Q07817
	Polymorphism : SNP, mutations, diseases
OMIM	600039    [ map ]
GENECLINICS	600039
SNP	BCL2L1 [dbSNP-NCBI]
SNP	NM_001191 [SNP-NCI]
SNP	NM_138578 [SNP-NCI]
SNP	BCL2L1 [GeneSNPs - Utah]  BCL2L1] [HGBASE - SRS]
HAPMAP	BCL2L1 [HAPMAP]
COSMIC	BCL2L1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	BCL2L1
	General knowledge
Family Browser	BCL2L1 [UCSC Family Browser]
SOURCE	NM_001191
SOURCE	NM_138578
SMD	Hs.516966
SAGE	Hs.516966
GO	release of cytochrome c from mitochondria [Amigo]  release of cytochrome c from mitochondria
GO	nucleus [Amigo]  nucleus
GO	nuclear envelope [Amigo]  nuclear envelope
GO	mitochondrion [Amigo]  mitochondrion
GO	mitochondrial outer membrane [Amigo]  mitochondrial outer membrane
GO	anti-apoptosis [Amigo]  anti-apoptosis
GO	negative regulation of survival gene product activity [Amigo]  negative regulation of survival gene product activity
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	identical protein binding [Amigo]  identical protein binding
GO	regulation of apoptosis [Amigo]  regulation of apoptosis
GO	regulation of mitochondrial membrane permeability [Amigo]  regulation of mitochondrial membrane permeability
GO	regulation of mitochondrial membrane potential [Amigo]  regulation of mitochondrial membrane potential
BIOCARTA	Opposing roles of AIF in Apoptosis and Cell Survival    [Genes]
BIOCARTA	Regulation of BAD phosphorylation    [Genes]
BIOCARTA	Apoptotic Signaling in Response to DNA Damage    [Genes]
BIOCARTA	IL-2 Receptor Beta Chain in T cell Activation    [Genes]
BIOCARTA	Role of Mitochondria in Apoptotic Signaling    [Genes]
BIOCARTA	Ras Signaling Pathway    [Genes]
KEGG	Neurodegenerative Disorders
KEGG	Apoptosis
KEGG	Jak-STAT signaling pathway
KEGG	Amyotrophic lateral sclerosis (ALS)
PubGene	BCL2L1
TreeFam	BCL2L1
CTD	598 [Comparative Genomics Database]
	Other databases
	Probes
Probe	BCL2L1 Related clones (RZPD - Berlin)
	PubMed
PubMed	235 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 19:57:30 2008