BCL3 (B-cell CLL/lymphoma 3)

Identity

Other names	BCL4
	D19S37
HGNC	BCL3
Location	19q13.1-q13.2
Location_base_pair	Starts at 49943818 and ends at 49955141 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

Breakpoints

External links

	Nomenclature
HGNC	BCL3   998
Entrez_Gene	BCL3  602  B-cell CLL/lymphoma 3
	Cards
GeneCards	BCL3
Ensembl	BCL3 [Search_View]   ENSG00000069399 [Gene_View]
Genatlas	BCL3
GeneLynx	BCL3
eGenome	BCL3
euGene	602
	Genomic and cartography
GoldenPath	BCL3  -     chr19:49943818-49955141 +  19q13.31   [Description]    (hg18-March_2006)
Ensembl	BCL3 - 19q13.31 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	BCL3
	Gene and transcription
Genbank	AK309453 [ ENTREZ ]
Genbank	BC064993 [ ENTREZ ]
Genbank	BU501187 [ ENTREZ ]
Genbank	M31732 [ ENTREZ ]
RefSeq	NM_005178 [ SRS ]    NM_005178 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NT_011109 [ SRS ]    NT_011109 [ ENTREZ ]
RefSeq	NW_001838496 [ SRS ]    NW_001838496 [ ENTREZ ]
RefSeq	NW_927217 [ SRS ]    NW_927217 [ ENTREZ ]
AceView	BCL3 AceView - NCBI
Unigene	Hs.31210 [ SRS ]    Hs.31210 [ NCBI ]     HS31210 [ spliceNest ]
Fast-db	13204 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P20749 [ SRS]    P20749 [ EXPASY ]     P20749 [ INTERPRO ]     P20749 [ UNIPROT ]
Prosite	PS50297 ANK_REP_REGION [ SRS ]    PS50297 ANK_REP_REGION [ Expasy ]
Prosite	PS50088 ANK_REPEAT [ SRS ]    PS50088 ANK_REPEAT [ Expasy ]
Interpro	IPR002110 ANK [ SRS ]    IPR002110 ANK [ EBI ]
CluSTr	P20749
Pfam	PF00023 Ank [ SRS ]    PF00023 Ank [ Sanger ]    pfam00023 [ NCBI-CDD ]
Smart	SM00248 ANK [EMBL]
Blocks	P20749
PDB	1K1A [ SRS ]    1K1A [ PdbSum ],   1K1A [ IMB ]   1K1A [ RSDB ]
PDB	1K1B [ SRS ]    1K1B [ PdbSum ],   1K1B [ IMB ]   1K1B [ RSDB ]
HPRD	00179
	Protein Interaction databases
DIP	P20749
IntAct	P20749
	Polymorphism : SNP, mutations, diseases
OMIM	109560    [ map ]
GENECLINICS	109560
SNP	BCL3 [dbSNP-NCBI]
SNP	NM_005178 [SNP-NCI]
SNP	BCL3 [GeneSNPs - Utah]  BCL3] [HGBASE - SRS]
HAPMAP	BCL3 [HAPMAP]
COSMIC	BCL3 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	protein [Translocation breakpoints In Cancer]
HGMD	BCL3
	General knowledge
Family Browser	BCL3 [UCSC Family Browser]
SOURCE	NM_005178
SMD	Hs.31210
SAGE	Hs.31210
GO	protein import into nucleus, translocation [Amigo]  protein import into nucleus, translocation
GO	follicular dendritic cell differentiation [Amigo]  follicular dendritic cell differentiation
GO	marginal zone B cell differentiation [Amigo]  marginal zone B cell differentiation
GO	humoral immune response mediated by circulating immunoglobulin [Amigo]  humoral immune response mediated by circulating immunoglobulin
GO	germinal center formation [Amigo]  germinal center formation
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	response to DNA damage stimulus [Amigo]  response to DNA damage stimulus
GO	I-kappaB kinase/NF-kappaB cascade [Amigo]  I-kappaB kinase/NF-kappaB cascade
GO	transcription factor binding [Amigo]  transcription factor binding
GO	response to virus [Amigo]  response to virus
GO	response to UV-C [Amigo]  response to UV-C
GO	negative regulation of transcription [Amigo]  negative regulation of transcription
GO	antimicrobial humoral response [Amigo]  antimicrobial humoral response
GO	extracellular matrix organization and biogenesis [Amigo]  extracellular matrix organization and biogenesis
GO	transcription regulator activity [Amigo]  transcription regulator activity
GO	protein binding, bridging [Amigo]  protein binding, bridging
GO	positive regulation of interferon-gamma production [Amigo]  positive regulation of interferon-gamma production
GO	Bcl3-Bcl10 complex [Amigo]  Bcl3-Bcl10 complex
GO	Bcl3/NF-kappaB2 complex [Amigo]  Bcl3/NF-kappaB2 complex
GO	T-helper 1 type immune response [Amigo]  T-helper 1 type immune response
GO	regulation of NF-kappaB import into nucleus [Amigo]  regulation of NF-kappaB import into nucleus
GO	negative regulation of tumor necrosis factor biosynthetic process [Amigo]  negative regulation of tumor necrosis factor biosynthetic process
GO	defense response to bacterium [Amigo]  defense response to bacterium
GO	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [Amigo]  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO	defense response to protozoan [Amigo]  defense response to protozoan
GO	negative regulation of apoptosis [Amigo]  negative regulation of apoptosis
GO	T-helper 2 cell differentiation [Amigo]  T-helper 2 cell differentiation
GO	positive regulation of interleukin-10 biosynthetic process [Amigo]  positive regulation of interleukin-10 biosynthetic process
GO	negative regulation of interleukin-8 biosynthetic process [Amigo]  negative regulation of interleukin-8 biosynthetic process
GO	positive regulation of translation [Amigo]  positive regulation of translation
GO	positive regulation of transcription [Amigo]  positive regulation of transcription
GO	positive regulation of transcription from RNA polymerase II promoter [Amigo]  positive regulation of transcription from RNA polymerase II promoter
GO	spleen development [Amigo]  spleen development
GO	regulation of DNA binding [Amigo]  regulation of DNA binding
GO	maintenance of protein location in nucleus [Amigo]  maintenance of protein location in nucleus
PubGene	BCL3
TreeFam	BCL3
CTD	602 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	BCL3 Related clones (RZPD - Berlin)
	PubMed
PubMed	47 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:32:08 2008