BECN1 (beclin 1)

2003-02-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
ATG6,VPS30,beclin1
FUSION GENES

Other Information

Locus ID:

NCBI: 8678
MIM: 604378
HGNC: 1034
Ensembl: ENSG00000126581

Variants:

dbSNP: 8678
ClinVar: 8678
TCGA: ENSG00000126581
COSMIC: BECN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126581ENST00000361523Q14457
ENSG00000126581ENST00000361523A0A024R1X5
ENSG00000126581ENST00000438274E7EV84
ENSG00000126581ENST00000586589K7ELY9
ENSG00000126581ENST00000587880K7EL88
ENSG00000126581ENST00000588276K7EMA2
ENSG00000126581ENST00000589636K7EQQ7
ENSG00000126581ENST00000589663K7ER46
ENSG00000126581ENST00000590099Q14457
ENSG00000126581ENST00000590099A0A024R1X5
ENSG00000126581ENST00000590764K7ES83
ENSG00000126581ENST00000590852K7ERY0
ENSG00000126581ENST00000591085K7EKK2
ENSG00000126581ENST00000593205K7EN35
ENSG00000126581ENST00000612631A0A087WVZ2

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Apoptosis - multiple speciesKEGGko04215
Apoptosis - multiple speciesKEGGhsa04215
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188430522008Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.457
192706962009Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.443
174468622007Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1.433
184978892008The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.371
180056792007HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein.368
185528352008Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.294
231122962012Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.256
219625182011Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.250
191801162009DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.245
190500712008Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.221

Citation

Dessen P

BECN1 (beclin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/786/becn1