CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)

Identity

Other names	-
HGNC	CAD
Location	2p22-p21
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CAD   1424
Entrez_Gene	CAD  790  carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
	Cards
GeneCards	CAD
Ensembl	CAD [Search_View]   ENSG00000084774 [Gene_View]
Genatlas	CAD
GeneLynx	CAD
eGenome	CAD
euGene	790
	Genomic and cartography
GoldenPath	CAD  -     chr2:27293762-27320158 +  2p23.3   [Description]    (hg18-March_2006)
Ensembl	CAD - 2p23.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CAD
	Gene and transcription
Genbank	AK226105 [ ENTREZ ]
Genbank	BC014178 [ ENTREZ ]
Genbank	BC065510 [ ENTREZ ]
Genbank	BM927624 [ ENTREZ ]
Genbank	BU541191 [ ENTREZ ]
RefSeq	NM_004341 [ SRS ]    NM_004341 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_022184 [ SRS ]    NT_022184 [ ENTREZ ]
RefSeq	NW_001838768 [ SRS ]    NW_001838768 [ ENTREZ ]
RefSeq	NW_927719 [ SRS ]    NW_927719 [ ENTREZ ]
AceView	CAD AceView - NCBI
Unigene	Hs.377010 [ SRS ]    Hs.377010 [ NCBI ]     HS377010 [ spliceNest ]
Fast-db	3108 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P27708 [ SRS]    P27708 [ EXPASY ]     P27708 [ INTERPRO ]     P27708 [ UNIPROT ]
Prosite	PS50975 ATP_GRASP [ SRS ]    PS50975 ATP_GRASP [ Expasy ]
Prosite	PS00097 CARBAMOYLTRANSFERASE [ SRS ]    PS00097 CARBAMOYLTRANSFERASE [ Expasy ]
Prosite	PS00866 CPSASE_1 [ SRS ]    PS00866 CPSASE_1 [ Expasy ]
Prosite	PS00867 CPSASE_2 [ SRS ]    PS00867 CPSASE_2 [ Expasy ]
Prosite	PS00482 DIHYDROOROTASE_1 [ SRS ]    PS00482 DIHYDROOROTASE_1 [ Expasy ]
Prosite	PS00483 DIHYDROOROTASE_2 [ SRS ]    PS00483 DIHYDROOROTASE_2 [ Expasy ]
Prosite	PS51273 GATASE_TYPE_1 [ SRS ]    PS51273 GATASE_TYPE_1 [ Expasy ]
Interpro	IPR006680 Amidohydro_1 [ SRS ]    IPR006680 Amidohydro_1 [ EBI ]
Interpro	IPR006220 Anth_synthII [ SRS ]    IPR006220 Anth_synthII [ EBI ]
Interpro	IPR006130 Asp/Orn_carbamoyltranf [ SRS ]    IPR006130 Asp/Orn_carbamoyltranf [ EBI ]
Interpro	IPR006132 Asp/Orn_carbamoyltranf_P_bd [ SRS ]    IPR006132 Asp/Orn_carbamoyltranf_P_bd [ EBI ]
Interpro	IPR006131 Asp_carbamoyltransf_Asp/Orn_bd [ SRS ]    IPR006131 Asp_carbamoyltransf_Asp/Orn_bd [ EBI ]
Interpro	IPR002082 Aspartate_carbamoyltransf_euk [ SRS ]    IPR002082 Aspartate_carbamoyltransf_euk [ EBI ]
Interpro	IPR011761 ATP-grasp [ SRS ]    IPR011761 ATP-grasp [ EBI ]
Interpro	IPR013816 ATP_grasp_subdomain_2 [ SRS ]    IPR013816 ATP_grasp_subdomain_2 [ EBI ]
Interpro	IPR001317 CarbamoylP_synth_GATase [ SRS ]    IPR001317 CarbamoylP_synth_GATase [ EBI ]
Interpro	IPR005483 CarbamoylP_synth_lsu [ SRS ]    IPR005483 CarbamoylP_synth_lsu [ EBI ]
Interpro	IPR005479 CarbamoylP_synth_lsu_ATP-bd [ SRS ]    IPR005479 CarbamoylP_synth_lsu_ATP-bd [ EBI ]
Interpro	IPR006275 CarbamoylP_synth_lsu_Gln-dep [ SRS ]    IPR006275 CarbamoylP_synth_lsu_Gln-dep [ EBI ]
Interpro	IPR005481 CarbamoylP_synth_lsu_N [ SRS ]    IPR005481 CarbamoylP_synth_lsu_N [ EBI ]
Interpro	IPR005480 CarbamoylP_synth_lsu_oligo [ SRS ]    IPR005480 CarbamoylP_synth_lsu_oligo [ EBI ]
Interpro	IPR006274 CarbamoylP_synth_ssu [ SRS ]    IPR006274 CarbamoylP_synth_ssu [ EBI ]
Interpro	IPR002474 CarbamoylP_synth_ssu_N [ SRS ]    IPR002474 CarbamoylP_synth_ssu_N [ EBI ]
Interpro	IPR004722 DHOmult [ SRS ]    IPR004722 DHOmult [ EBI ]
Interpro	IPR002195 Dihydroorotase_CS [ SRS ]    IPR002195 Dihydroorotase_CS [ EBI ]
Interpro	IPR011702 GATASE [ SRS ]    IPR011702 GATASE [ EBI ]
Interpro	IPR012998 GATase_1_AS [ SRS ]    IPR012998 GATase_1_AS [ EBI ]
Interpro	IPR000991 GATase_class1_C [ SRS ]    IPR000991 GATase_class1_C [ EBI ]
Interpro	IPR011607 MGS [ SRS ]    IPR011607 MGS [ EBI ]
Interpro	IPR013817 Pre-ATP_grasp [ SRS ]    IPR013817 Pre-ATP_grasp [ EBI ]
CluSTr	P27708
Pfam	PF01979 Amidohydro_1 [ SRS ]    PF01979 Amidohydro_1 [ Sanger ]    pfam01979 [ NCBI-CDD ]
Pfam	PF00289 CPSase_L_chain [ SRS ]    PF00289 CPSase_L_chain [ Sanger ]    pfam00289 [ NCBI-CDD ]
Pfam	PF02786 CPSase_L_D2 [ SRS ]    PF02786 CPSase_L_D2 [ Sanger ]    pfam02786 [ NCBI-CDD ]
Pfam	PF02787 CPSase_L_D3 [ SRS ]    PF02787 CPSase_L_D3 [ Sanger ]    pfam02787 [ NCBI-CDD ]
Pfam	PF00988 CPSase_sm_chain [ SRS ]    PF00988 CPSase_sm_chain [ Sanger ]    pfam00988 [ NCBI-CDD ]
Pfam	PF00117 GATase [ SRS ]    PF00117 GATase [ Sanger ]    pfam00117 [ NCBI-CDD ]
Pfam	PF02142 MGS [ SRS ]    PF02142 MGS [ Sanger ]    pfam02142 [ NCBI-CDD ]
Pfam	PF00185 OTCace [ SRS ]    PF00185 OTCace [ Sanger ]    pfam00185 [ NCBI-CDD ]
Pfam	PF02729 OTCace_N [ SRS ]    PF02729 OTCace_N [ Sanger ]    pfam02729 [ NCBI-CDD ]
Blocks	P27708
HPRD	06437
	Protein Interaction databases
DIP	P27708
IntAct	P27708
	Polymorphism : SNP, mutations, diseases
OMIM	114010    [ map ]
GENECLINICS	114010
SNP	CAD [dbSNP-NCBI]
SNP	NM_004341 [SNP-NCI]
SNP	CAD [GeneSNPs - Utah]  CAD] [HGBASE - SRS]
HAPMAP	CAD [HAPMAP]
COSMIC	CAD [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	CAD
	General knowledge
Family Browser	CAD [UCSC Family Browser]
SOURCE	NM_004341
SMD	Hs.377010
SAGE	Hs.377010
Enzyme	6.3.5.5 [ Enzyme-Expasy ]   6.3.5.5 [ Enzyme-SRS ]   6.3.5.5 [ IntEnz-EBI ]   6.3.5.5 [ BRENDA ]   6.3.5.5 [ KEGG ]   6.3.5.5 [ WIT ]
GO	aspartate carbamoyltransferase activity [Amigo]  aspartate carbamoyltransferase activity
GO	carbamoyl-phosphate synthase activity [Amigo]  carbamoyl-phosphate synthase activity
GO	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Amigo]  carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO	dihydroorotase activity [Amigo]  dihydroorotase activity
GO	dihydroorotase activity [Amigo]  dihydroorotase activity
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	'de novo' pyrimidine base biosynthetic process [Amigo]  'de novo' pyrimidine base biosynthetic process
GO	pyrimidine nucleotide biosynthetic process [Amigo]  pyrimidine nucleotide biosynthetic process
GO	amino acid metabolic process [Amigo]  amino acid metabolic process
GO	glutamine metabolic process [Amigo]  glutamine metabolic process
GO	nitrogen compound metabolic process [Amigo]  nitrogen compound metabolic process
GO	zinc ion binding [Amigo]  zinc ion binding
GO	biosynthetic process [Amigo]  biosynthetic process
GO	amino acid binding [Amigo]  amino acid binding
GO	transferase activity [Amigo]  transferase activity
GO	ligase activity [Amigo]  ligase activity
GO	metal ion binding [Amigo]  metal ion binding
BIOCARTA	Apoptotic DNA fragmentation and tissue homeostasis    [Genes]
BIOCARTA	HIV-I Nef: negative effector of Fas and TNF    [Genes]
BIOCARTA	Caspase Cascade in Apoptosis    [Genes]
BIOCARTA	Induction of apoptosis through DR3 and DR4/5 Death Receptors    [Genes]
BIOCARTA	FAS signaling pathway ( CD95 )    [Genes]
BIOCARTA	Role of Mitochondria in Apoptotic Signaling    [Genes]
BIOCARTA	Granzyme A mediated Apoptosis Pathway    [Genes]
BIOCARTA	TNFR1 Signaling Pathway    [Genes]
KEGG	Pyrimidine metabolism
KEGG	Glutamate metabolism
KEGG	Alanine and aspartate metabolism
PubGene	CAD
TreeFam	CAD
CTD	790 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CAD Related clones (RZPD - Berlin)
	PubMed
PubMed	21 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:02:57 2008