CBX3 (chromobox 3)

2003-05-01  

Identity

HGNC
CBX3
LOCATION
7p15.2
LOCUSID
11335
ALIAS
HECH,HP1-GAMMA,HP1Hs-gamma
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11335
MIM: 604477
HGNC: 1553
Ensembl: ENSG00000122565

Variants:

dbSNP: 11335
ClinVar: 11335
TCGA: ENSG00000122565
COSMIC: CBX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122565ENST00000337620Q13185
ENSG00000122565ENST00000337620A4D177
ENSG00000122565ENST00000396386Q13185
ENSG00000122565ENST00000396386A4D177
ENSG00000122565ENST00000409747B8ZZ43
ENSG00000122565ENST00000456948C9JMM0
ENSG00000122565ENST00000462165S4R2Y4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
125605552003Maintenance of stable heterochromatin domains by dynamic HP1 binding.191
172454322007Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency.151
169543812006The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression.130
213586302011Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.111
181720132008Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene.58
218653252011A role for heterochromatin protein 1γ at human telomeres.54
226842802012CBX3 regulates efficient RNA processing genome-wide.33
256342092015Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage.33
263338082015Heterochromatin protein HP1γ promotes colorectal cancer progression and is regulated by miR-30a.33
182396892008Regulation of an inducible promoter by an HP1beta-HP1gamma switch.29

Citation

Dessen P

CBX3 (chromobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/936/cbx3