CD4 (CD4 molecule)

Identity

Other names	CD4mut
HGNC	CD4
Location	12pter-p12
Location_base_pair	Starts at 6768912 and ends at 6800237 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CD4   1678
Entrez_Gene	CD4  920  CD4 molecule
	Cards
GeneCards	CD4
Ensembl	CD4 [Search_View]   ENSG00000010610 [Gene_View]
Genatlas	CD4
GeneLynx	CD4
eGenome	CD4
euGene	920
	Genomic and cartography
GoldenPath	CD4  -     chr12:6768912-6800237 +  12p13.31   [Description]    (hg18-March_2006)
Ensembl	CD4 - 12p13.31 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CD4
	Gene and transcription
Genbank	AK308344 [ ENTREZ ]
Genbank	AK310652 [ ENTREZ ]
Genbank	AK310677 [ ENTREZ ]
Genbank	AK310687 [ ENTREZ ]
Genbank	AK311495 [ ENTREZ ]
RefSeq	NM_000616 [ SRS ]    NM_000616 [ ENTREZ ]
RefSeq	AC_000055 [ SRS ]    AC_000055 [ ENTREZ ]
RefSeq	AC_000144 [ SRS ]    AC_000144 [ ENTREZ ]
RefSeq	NC_000012 [ SRS ]    NC_000012 [ ENTREZ ]
RefSeq	NT_009759 [ SRS ]    NT_009759 [ ENTREZ ]
RefSeq	NW_001838050 [ SRS ]    NW_001838050 [ ENTREZ ]
RefSeq	NW_925295 [ SRS ]    NW_925295 [ ENTREZ ]
AceView	CD4 AceView - NCBI
Unigene	Hs.631659 [ SRS ]    Hs.631659 [ NCBI ]     HS631659 [ spliceNest ]
Fast-db	1318 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P01730 [ SRS]    P01730 [ EXPASY ]     P01730 [ INTERPRO ]     P01730 [ UNIPROT ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Interpro	IPR000973 Ag_CD4 [ SRS ]    IPR000973 Ag_CD4 [ EBI ]
Interpro	IPR015274 CD4-extracel [ SRS ]    IPR015274 CD4-extracel [ EBI ]
Interpro	IPR013151 Ig [ SRS ]    IPR013151 Ig [ EBI ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR008424 Ig_C2-set [ SRS ]    IPR008424 Ig_C2-set [ EBI ]
Interpro	IPR003599 Ig_sub [ SRS ]    IPR003599 Ig_sub [ EBI ]
Interpro	IPR003596 Ig_V-set_sub [ SRS ]    IPR003596 Ig_V-set_sub [ EBI ]
CluSTr	P01730
Pfam	PF05790 C2-set [ SRS ]    PF05790 C2-set [ Sanger ]    pfam05790 [ NCBI-CDD ]
Pfam	PF09191 CD4-extracel [ SRS ]    PF09191 CD4-extracel [ Sanger ]    pfam09191 [ NCBI-CDD ]
Pfam	PF00047 ig [ SRS ]    PF00047 ig [ Sanger ]    pfam00047 [ NCBI-CDD ]
Smart	SM00409 IG [EMBL]
Smart	SM00406 IGv [EMBL]
Blocks	P01730
PDB	1CDH [ SRS ]    1CDH [ PdbSum ],   1CDH [ IMB ]   1CDH [ RSDB ]
PDB	1CDI [ SRS ]    1CDI [ PdbSum ],   1CDI [ IMB ]   1CDI [ RSDB ]
PDB	1CDJ [ SRS ]    1CDJ [ PdbSum ],   1CDJ [ IMB ]   1CDJ [ RSDB ]
PDB	1CDU [ SRS ]    1CDU [ PdbSum ],   1CDU [ IMB ]   1CDU [ RSDB ]
PDB	1CDY [ SRS ]    1CDY [ PdbSum ],   1CDY [ IMB ]   1CDY [ RSDB ]
PDB	1G9M [ SRS ]    1G9M [ PdbSum ],   1G9M [ IMB ]   1G9M [ RSDB ]
PDB	1G9N [ SRS ]    1G9N [ PdbSum ],   1G9N [ IMB ]   1G9N [ RSDB ]
PDB	1GC1 [ SRS ]    1GC1 [ PdbSum ],   1GC1 [ IMB ]   1GC1 [ RSDB ]
PDB	1JL4 [ SRS ]    1JL4 [ PdbSum ],   1JL4 [ IMB ]   1JL4 [ RSDB ]
PDB	1OPN [ SRS ]    1OPN [ PdbSum ],   1OPN [ IMB ]   1OPN [ RSDB ]
PDB	1OPT [ SRS ]    1OPT [ PdbSum ],   1OPT [ IMB ]   1OPT [ RSDB ]
PDB	1OPW [ SRS ]    1OPW [ PdbSum ],   1OPW [ IMB ]   1OPW [ RSDB ]
PDB	1Q68 [ SRS ]    1Q68 [ PdbSum ],   1Q68 [ IMB ]   1Q68 [ RSDB ]
PDB	1RZJ [ SRS ]    1RZJ [ PdbSum ],   1RZJ [ IMB ]   1RZJ [ RSDB ]
PDB	1RZK [ SRS ]    1RZK [ PdbSum ],   1RZK [ IMB ]   1RZK [ RSDB ]
PDB	1WBR [ SRS ]    1WBR [ PdbSum ],   1WBR [ IMB ]   1WBR [ RSDB ]
PDB	1WIO [ SRS ]    1WIO [ PdbSum ],   1WIO [ IMB ]   1WIO [ RSDB ]
PDB	1WIP [ SRS ]    1WIP [ PdbSum ],   1WIP [ IMB ]   1WIP [ RSDB ]
PDB	1WIQ [ SRS ]    1WIQ [ PdbSum ],   1WIQ [ IMB ]   1WIQ [ RSDB ]
PDB	2B4C [ SRS ]    2B4C [ PdbSum ],   2B4C [ IMB ]   2B4C [ RSDB ]
PDB	2NXY [ SRS ]    2NXY [ PdbSum ],   2NXY [ IMB ]   2NXY [ RSDB ]
PDB	2NXZ [ SRS ]    2NXZ [ PdbSum ],   2NXZ [ IMB ]   2NXZ [ RSDB ]
PDB	2NY0 [ SRS ]    2NY0 [ PdbSum ],   2NY0 [ IMB ]   2NY0 [ RSDB ]
PDB	2NY1 [ SRS ]    2NY1 [ PdbSum ],   2NY1 [ IMB ]   2NY1 [ RSDB ]
PDB	2NY2 [ SRS ]    2NY2 [ PdbSum ],   2NY2 [ IMB ]   2NY2 [ RSDB ]
PDB	2NY3 [ SRS ]    2NY3 [ PdbSum ],   2NY3 [ IMB ]   2NY3 [ RSDB ]
PDB	2NY4 [ SRS ]    2NY4 [ PdbSum ],   2NY4 [ IMB ]   2NY4 [ RSDB ]
PDB	2NY5 [ SRS ]    2NY5 [ PdbSum ],   2NY5 [ IMB ]   2NY5 [ RSDB ]
PDB	2NY6 [ SRS ]    2NY6 [ PdbSum ],   2NY6 [ IMB ]   2NY6 [ RSDB ]
PDB	2QAD [ SRS ]    2QAD [ PdbSum ],   2QAD [ IMB ]   2QAD [ RSDB ]
PDB	3CD4 [ SRS ]    3CD4 [ PdbSum ],   3CD4 [ IMB ]   3CD4 [ RSDB ]
HPRD	01740
	Protein Interaction databases
DIP	P01730
IntAct	P01730
	Polymorphism : SNP, mutations, diseases
OMIM	186940    [ map ]
GENECLINICS	186940
SNP	CD4 [dbSNP-NCBI]
SNP	NM_000616 [SNP-NCI]
SNP	CD4 [GeneSNPs - Utah]  CD4] [HGBASE - SRS]
HAPMAP	CD4 [HAPMAP]
HGMD	CD4
	General knowledge
Family Browser	CD4 [UCSC Family Browser]
SOURCE	NM_000616
SMD	Hs.631659
SAGE	Hs.631659
GO	conjugation with cellular fusion [Amigo]  conjugation with cellular fusion
GO	cytokine production [Amigo]  cytokine production
GO	glycoprotein binding [Amigo]  glycoprotein binding
GO	transmembrane receptor activity [Amigo]  transmembrane receptor activity
GO	extracellular matrix structural constituent [Amigo]  extracellular matrix structural constituent
GO	early endosome [Amigo]  early endosome
GO	endoplasmic reticulum membrane [Amigo]  endoplasmic reticulum membrane
GO	plasma membrane [Amigo]  plasma membrane
GO	plasma membrane [Amigo]  plasma membrane
GO	immune response [Amigo]  immune response
GO	cell adhesion [Amigo]  cell adhesion
GO	transmembrane receptor protein tyrosine kinase signaling pathway [Amigo]  transmembrane receptor protein tyrosine kinase signaling pathway
GO	zinc ion binding [Amigo]  zinc ion binding
GO	external side of plasma membrane [Amigo]  external side of plasma membrane
GO	coreceptor activity [Amigo]  coreceptor activity
GO	integral to membrane [Amigo]  integral to membrane
GO	initiation of viral infection [Amigo]  initiation of viral infection
GO	protein kinase binding [Amigo]  protein kinase binding
GO	T cell receptor complex [Amigo]  T cell receptor complex
GO	MHC class II protein binding [Amigo]  MHC class II protein binding
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	interspecies interaction between organisms [Amigo]  interspecies interaction between organisms
GO	T cell selection [Amigo]  T cell selection
GO	positive regulation of interleukin-2 biosynthetic process [Amigo]  positive regulation of interleukin-2 biosynthetic process
GO	positive regulation of protein kinase activity [Amigo]  positive regulation of protein kinase activity
GO	positive regulation of peptidyl-tyrosine phosphorylation [Amigo]  positive regulation of peptidyl-tyrosine phosphorylation
GO	positive regulation of calcium-mediated signaling [Amigo]  positive regulation of calcium-mediated signaling
GO	positive regulation of T cell activation [Amigo]  positive regulation of T cell activation
BIOCARTA	Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor    [Genes]
BIOCARTA	Antigen Dependent B Cell Activation    [Genes]
BIOCARTA	Bystander B Cell Activation    [Genes]
BIOCARTA	IL 17 Signaling Pathway    [Genes]
BIOCARTA	IL 5 Signaling Pathway    [Genes]
BIOCARTA	Cytokines and Inflammatory Response    [Genes]
BIOCARTA	Selective expression of chemokine receptors during T-cell polarization    [Genes]
BIOCARTA	NO2-dependent IL 12 Pathway in NK cells    [Genes]
BIOCARTA	Regulation of hematopoiesis by cytokines    [Genes]
BIOCARTA	HIV Induced T Cell Apoptosis    [Genes]
BIOCARTA	Lck and Fyn tyrosine kinases in initiation of TCR Activation    [Genes]
BIOCARTA	T Helper Cell Surface Molecules    [Genes]
BIOCARTA	HIV-1 defeats host-mediated resistance by CEM15    [Genes]
KEGG	Cell adhesion molecules (CAMs)
KEGG	Antigen processing and presentation
KEGG	Hematopoietic cell lineage
KEGG	T cell receptor signaling pathway
PubGene	CD4
TreeFam	CD4
CTD	920 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CD4 Related clones (RZPD - Berlin)
	PubMed
PubMed	499 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:06:45 2008