CDC37 (cell division cycle 37, HSP90 cochaperone)

2003-08-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
P50CDC37
FUSION GENES

Other Information

Locus ID:

NCBI: 11140
MIM: 605065
HGNC: 1735
Ensembl: ENSG00000105401

Variants:

dbSNP: 11140
ClinVar: 11140
TCGA: ENSG00000105401
COSMIC: CDC37

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105401ENST00000222005Q16543
ENSG00000105401ENST00000222005A0A024R7B7
ENSG00000105401ENST00000588869K7EJ06
ENSG00000105401ENST00000589331K7EIU0
ENSG00000105401ENST00000589625K7EL68
ENSG00000105401ENST00000589629K7EQA9
ENSG00000105401ENST00000593124K7EKQ2

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by EGFR in CancerREACTOMER-HSA-1643713
Signaling by Ligand-Responsive EGFR Variants in CancerREACTOMER-HSA-5637815
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsREACTOMER-HSA-1236382
Signaling by EGFRvIII in CancerREACTOMER-HSA-5637812
Constitutive Signaling by EGFRvIIIREACTOMER-HSA-5637810
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121769972002Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.189
169493662006Structure of an Hsp90-Cdc37-Cdk4 complex.116
118646122002TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90.101
119169742002Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.90
189224702008Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.69
198582142009Characterization of celastrol to inhibit hsp90 and cdc37 interaction.66
180036392008Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.62
190917462009The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.53
227276662012Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.50
189317002009Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors.44

Citation

Dessen P

CDC37 (cell division cycle 37, HSP90 cochaperone)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40011/cdc37