CDK5 (cyclin dependent kinase 5)

2003-05-01  

Identity

HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
LIS7,PSSALRE
FUSION GENES

Other Information

Locus ID:

NCBI: 1020
MIM: 123831
HGNC: 1774
Ensembl: ENSG00000164885

Variants:

dbSNP: 1020
ClinVar: 1020
TCGA: ENSG00000164885
COSMIC: CDK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164885ENST00000297518Q00535
ENSG00000164885ENST00000297518A0A0S2Z355
ENSG00000164885ENST00000485972Q00535
ENSG00000164885ENST00000485972A0A090N7W4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Alzheimer's diseaseKEGGko05010
Axon guidanceKEGGhsa04360
Alzheimer's diseaseKEGGhsa05010
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
DiseaseREACTOMER-HSA-1643685
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
Opioid SignallingREACTOMER-HSA-111885
DARPP-32 eventsREACTOMER-HSA-180024
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
CRMPs in Sema3A signalingREACTOMER-HSA-399956
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33639PPP1R1BGenePathwayassociated

References

Pubmed IDYearTitleCitations
206516832010Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.328
127656082003Cdk5 is a key factor in tau aggregation and tangle formation in vivo.141
185983502008Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.97
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
241352812013The role of Cdk5 in neuroendocrine thyroid cancer.66
211454892010The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose.64
218443612011S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
170360522006A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death.61
159118792005Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.56

Citation

Dessen P

CDK5 (cyclin dependent kinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40033/cdk5