CDK6 (cyclin-dependent kinase 6)

Identity

Other names	MGC59692
	PLSTIRE
HGNC	CDK6
Location	7q21-q22
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CDK6   1777
Entrez_Gene	CDK6  1021  cyclin-dependent kinase 6
	Cards
GeneCards	CDK6
Ensembl	CDK6 [Search_View]   ENSG00000105810 [Gene_View]
Genatlas	CDK6
GeneLynx	CDK6
eGenome	CDK6
euGene	1021
	Genomic and cartography
GoldenPath	CDK6  -     chr7:92072171-92301148 -  7q21.2   [Description]    (hg18-March_2006)
Ensembl	CDK6 - 7q21.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CDK6
	Gene and transcription
Genbank	AA312213 [ ENTREZ ]
Genbank	AB073601 [ ENTREZ ]
Genbank	AI023175 [ ENTREZ ]
Genbank	AI367890 [ ENTREZ ]
Genbank	AI400582 [ ENTREZ ]
RefSeq	NM_001259 [ SRS ]    NM_001259 [ ENTREZ ]
RefSeq	AC_000050 [ SRS ]    AC_000050 [ ENTREZ ]
RefSeq	AC_000068 [ SRS ]    AC_000068 [ ENTREZ ]
RefSeq	AC_000139 [ SRS ]    AC_000139 [ ENTREZ ]
RefSeq	NC_000007 [ SRS ]    NC_000007 [ ENTREZ ]
RefSeq	NT_007933 [ SRS ]    NT_007933 [ ENTREZ ]
RefSeq	NT_079595 [ SRS ]    NT_079595 [ ENTREZ ]
RefSeq	NW_001839064 [ SRS ]    NW_001839064 [ ENTREZ ]
RefSeq	NW_923574 [ SRS ]    NW_923574 [ ENTREZ ]
AceView	CDK6 AceView - NCBI
Unigene	Hs.119882 [ SRS ]    Hs.119882 [ NCBI ]     HS119882 [ spliceNest ]
Fast-db	8349 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q00534 [ SRS]    Q00534 [ EXPASY ]     Q00534 [ INTERPRO ]     Q00534 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	Q00534
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q00534 CDK6_HUMAN [ Domain structure ]   Q00534 CDK6_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q00534
PDB	1BI7 [ SRS ]    1BI7 [ PdbSum ],   1BI7 [ IMB ]   1BI7 [ RSDB ]
PDB	1BI8 [ SRS ]    1BI8 [ PdbSum ],   1BI8 [ IMB ]   1BI8 [ RSDB ]
PDB	1BLX [ SRS ]    1BLX [ PdbSum ],   1BLX [ IMB ]   1BLX [ RSDB ]
PDB	1G3N [ SRS ]    1G3N [ PdbSum ],   1G3N [ IMB ]   1G3N [ RSDB ]
PDB	1JOW [ SRS ]    1JOW [ PdbSum ],   1JOW [ IMB ]   1JOW [ RSDB ]
PDB	1XO2 [ SRS ]    1XO2 [ PdbSum ],   1XO2 [ IMB ]   1XO2 [ RSDB ]
PDB	2EUF [ SRS ]    2EUF [ PdbSum ],   2EUF [ IMB ]   2EUF [ RSDB ]
PDB	2F2C [ SRS ]    2F2C [ PdbSum ],   2F2C [ IMB ]   2F2C [ RSDB ]
HPRD	04533
	Protein Interaction databases
DIP	Q00534
IntAct	Q00534
	Polymorphism : SNP, mutations, diseases
OMIM	603368    [ map ]
GENECLINICS	603368
SNP	CDK6 [dbSNP-NCBI]
SNP	NM_001259 [SNP-NCI]
SNP	CDK6 [GeneSNPs - Utah]  CDK6] [HGBASE - SRS]
HAPMAP	CDK6 [HAPMAP]
COSMIC	CDK6 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	G1 [Translocation breakpoints In Cancer]
HGMD	CDK6
	General knowledge
Family Browser	CDK6 [UCSC Family Browser]
SOURCE	NM_001259
SMD	Hs.119882
SAGE	Hs.119882
Enzyme	2.7.11.22 [ Enzyme-Expasy ]   2.7.11.22 [ Enzyme-SRS ]   2.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   2.7.11.22 [ WIT ]
GO	G1 phase of mitotic cell cycle [Amigo]  G1 phase of mitotic cell cycle
GO	nucleotide binding [Amigo]  nucleotide binding
GO	cyclin-dependent protein kinase holoenzyme complex [Amigo]  cyclin-dependent protein kinase holoenzyme complex
GO	ruffle [Amigo]  ruffle
GO	positive regulation of cell-matrix adhesion [Amigo]  positive regulation of cell-matrix adhesion
GO	cyclin-dependent protein kinase activity [Amigo]  cyclin-dependent protein kinase activity
GO	ATP binding [Amigo]  ATP binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	cell cycle [Amigo]  cell cycle
GO	regulation of gene expression [Amigo]  regulation of gene expression
GO	regulation of gene expression [Amigo]  regulation of gene expression
GO	transferase activity [Amigo]  transferase activity
GO	cyclin binding [Amigo]  cyclin binding
GO	gliogenesis [Amigo]  gliogenesis
GO	cell dedifferentiation [Amigo]  cell dedifferentiation
GO	regulation of erythrocyte differentiation [Amigo]  regulation of erythrocyte differentiation
GO	negative regulation of osteoblast differentiation [Amigo]  negative regulation of osteoblast differentiation
GO	positive regulation of fibroblast proliferation [Amigo]  positive regulation of fibroblast proliferation
GO	negative regulation of epithelial cell proliferation [Amigo]  negative regulation of epithelial cell proliferation
GO	cell division [Amigo]  cell division
BIOCARTA	Estrogen-responsive protein Efp controls cell cycle and breast tumors growth    [Genes]
BIOCARTA	Influence of Ras and Rho proteins on G1 to S Transition    [Genes]
BIOCARTA	Cyclins and Cell Cycle Regulation    [Genes]
BIOCARTA	Cell Cycle: G1/S Check Point    [Genes]
KEGG	Cell cycle
PubGene	CDK6
TreeFam	CDK6
CTD	1021 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CDK6 Related clones (RZPD - Berlin)
	PubMed
PubMed	74 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:04:30 2008