CDK8 (cyclin-dependent kinase 8)

Identity

Other names	K35
	MGC126074
	MGC126075
HGNC	CDK8
Location	13q12
Location_base_pair	Starts at 25726756 and ends at 25876569 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CDK8   1779
Entrez_Gene	CDK8  1024  cyclin-dependent kinase 8
	Cards
GeneCards	CDK8
Ensembl	CDK8 [Search_View]   ENSG00000132964 [Gene_View]
Genatlas	CDK8
GeneLynx	CDK8
eGenome	CDK8
euGene	1024
	Genomic and cartography
GoldenPath	CDK8  -  13q12   chr13:25726756-25876569 +  13q12.13   [Description]    (hg18-March_2006)
Ensembl	CDK8 - 13q12.13 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CDK8
	Gene and transcription
Genbank	AK296084 [ ENTREZ ]
Genbank	AK296875 [ ENTREZ ]
Genbank	AY702976 [ ENTREZ ]
Genbank	BC069634 [ ENTREZ ]
Genbank	BC094784 [ ENTREZ ]
RefSeq	NM_001260 [ SRS ]    NM_001260 [ ENTREZ ]
RefSeq	AC_000056 [ SRS ]    AC_000056 [ ENTREZ ]
RefSeq	AC_000145 [ SRS ]    AC_000145 [ ENTREZ ]
RefSeq	NC_000013 [ SRS ]    NC_000013 [ ENTREZ ]
RefSeq	NT_024524 [ SRS ]    NT_024524 [ ENTREZ ]
RefSeq	NW_001838070 [ SRS ]    NW_001838070 [ ENTREZ ]
RefSeq	NW_925473 [ SRS ]    NW_925473 [ ENTREZ ]
AceView	CDK8 AceView - NCBI
Unigene	Hs.382306 [ SRS ]    Hs.382306 [ NCBI ]     HS382306 [ spliceNest ]
Fast-db	1567 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P49336 [ SRS]    P49336 [ EXPASY ]     P49336 [ INTERPRO ]     P49336 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	P49336
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P49336 CDK8_HUMAN [ Domain structure ]   P49336 CDK8_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P49336
HPRD	04422
	Protein Interaction databases
DIP	P49336
IntAct	P49336
	Polymorphism : SNP, mutations, diseases
OMIM	603184    [ map ]
GENECLINICS	603184
SNP	CDK8 [dbSNP-NCBI]
SNP	NM_001260 [SNP-NCI]
SNP	CDK8 [GeneSNPs - Utah]  CDK8] [HGBASE - SRS]
HAPMAP	CDK8 [HAPMAP]
COSMIC	CDK8 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	CDK8
	General knowledge
Family Browser	CDK8 [UCSC Family Browser]
SOURCE	NM_001260
SMD	Hs.382306
SAGE	Hs.382306
Enzyme	2.7.11.22 [ Enzyme-Expasy ]   2.7.11.22 [ Enzyme-SRS ]   2.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   2.7.11.22 [ WIT ]
GO	mediator complex [Amigo]  mediator complex
GO	nucleotide binding [Amigo]  nucleotide binding
GO	protein kinase activity [Amigo]  protein kinase activity
GO	cyclin-dependent protein kinase activity [Amigo]  cyclin-dependent protein kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	nucleus [Amigo]  nucleus
GO	transcription [Amigo]  transcription
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	RNA polymerase subunit kinase activity [Amigo]  RNA polymerase subunit kinase activity
GO	transferase activity [Amigo]  transferase activity
PubGene	CDK8
TreeFam	CDK8
CTD	1024 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CDK8 Related clones (RZPD - Berlin)
	PubMed
PubMed	31 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Tue Oct 14 20:26:11 2008