CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4))

Identity

Other names	CDK4I
	INK4B
	MTS2
	P15
	TP15
	p15INK4b
HGNC	CDKN2B
Location	9p21
Location_base_pair	Starts at 21992902 and ends at 21999312 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CDKN2B   1788
Entrez_Gene	CDKN2B  1030  cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
	Cards
GeneCards	CDKN2B
Ensembl	CDKN2B [Search_View]   ENSG00000147883 [Gene_View]
Genatlas	CDKN2B
GeneLynx	CDKN2B
eGenome	CDKN2B
euGene	1030
	Genomic and cartography
GoldenPath	CDKN2B  -  9p21   chr9:21992902-21999312 -  9p21.3   [Description]    (hg18-March_2006)
Ensembl	CDKN2B - 9p21.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CDKN2B
	Gene and transcription
Genbank	AF004819 [ ENTREZ ]
Genbank	AF488409 [ ENTREZ ]
Genbank	AF488410 [ ENTREZ ]
Genbank	AF488731 [ ENTREZ ]
Genbank	AM392641 [ ENTREZ ]
RefSeq	NM_004936 [ SRS ]    NM_004936 [ ENTREZ ]
RefSeq	NM_078487 [ SRS ]    NM_078487 [ ENTREZ ]
RefSeq	AC_000052 [ SRS ]    AC_000052 [ ENTREZ ]
RefSeq	AC_000141 [ SRS ]    AC_000141 [ ENTREZ ]
RefSeq	NC_000009 [ SRS ]    NC_000009 [ ENTREZ ]
RefSeq	NT_008413 [ SRS ]    NT_008413 [ ENTREZ ]
RefSeq	NW_001839149 [ SRS ]    NW_001839149 [ ENTREZ ]
RefSeq	NW_924062 [ SRS ]    NW_924062 [ ENTREZ ]
AceView	CDKN2B AceView - NCBI
Unigene	Hs.72901 [ SRS ]    Hs.72901 [ NCBI ]     HS72901 [ spliceNest ]
Fast-db	3535 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O15125 [ SRS]    O15125 [ EXPASY ]     O15125 [ INTERPRO ]     O15125 [ UNIPROT ]
Prosite	PS50297 ANK_REP_REGION [ SRS ]    PS50297 ANK_REP_REGION [ Expasy ]
Interpro	IPR002110 ANK [ SRS ]    IPR002110 ANK [ EBI ]
CluSTr	O15125
Blocks	O15125
HPRD	02696
	Protein Interaction databases
DIP	O15125
IntAct	O15125
	Polymorphism : SNP, mutations, diseases
OMIM	600431    [ map ]
GENECLINICS	600431
SNP	CDKN2B [dbSNP-NCBI]
SNP	NM_004936 [SNP-NCI]
SNP	NM_078487 [SNP-NCI]
SNP	CDKN2B [GeneSNPs - Utah]  CDKN2B] [HGBASE - SRS]
HAPMAP	CDKN2B [HAPMAP]
COSMIC	CDKN2B [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	CDKN2B
	General knowledge
Family Browser	CDKN2B [UCSC Family Browser]
SOURCE	NM_004936
SOURCE	NM_078487
SMD	Hs.72901
SAGE	Hs.72901
GO	regulation of cyclin-dependent protein kinase activity [Amigo]  regulation of cyclin-dependent protein kinase activity
GO	G2/M transition of mitotic cell cycle [Amigo]  G2/M transition of mitotic cell cycle
GO	cyclin-dependent protein kinase inhibitor activity [Amigo]  cyclin-dependent protein kinase inhibitor activity
GO	cyclin-dependent protein kinase inhibitor activity [Amigo]  cyclin-dependent protein kinase inhibitor activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	cell cycle arrest [Amigo]  cell cycle arrest
GO	kinase activity [Amigo]  kinase activity
GO	protein kinase binding [Amigo]  protein kinase binding
GO	positive regulation of transforming growth factor beta receptor signaling pathway [Amigo]  positive regulation of transforming growth factor beta receptor signaling pathway
GO	G1/S transition checkpoint [Amigo]  G1/S transition checkpoint
GO	cellular response to extracellular stimulus [Amigo]  cellular response to extracellular stimulus
GO	cellular response to nutrient [Amigo]  cellular response to nutrient
GO	negative regulation of phosphorylation [Amigo]  negative regulation of phosphorylation
GO	negative regulation of cell cycle [Amigo]  negative regulation of cell cycle
GO	negative regulation of epithelial cell proliferation [Amigo]  negative regulation of epithelial cell proliferation
BIOCARTA	Cyclins and Cell Cycle Regulation    [Genes]
BIOCARTA	Cell Cycle: G1/S Check Point    [Genes]
KEGG	Cell cycle
KEGG	TGF-beta signaling pathway
PubGene	CDKN2B
TreeFam	CDKN2B
CTD	1030 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CDKN2B Related clones (RZPD - Berlin)
	PubMed
PubMed	101 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:07:17 2008