CDKN2C (cyclin dependent kinase inhibitor 2C)

2003-02-01  

Identity

HGNC
LOCATION
1p32.3
LOCUSID
ALIAS
INK4C,p18,p18-INK4C

Other Information

Locus ID:

NCBI: 1031
MIM: 603369
HGNC: 1789
Ensembl: ENSG00000123080

Variants:

dbSNP: 1031
ClinVar: 1031
TCGA: ENSG00000123080
COSMIC: CDKN2C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123080ENST00000262662P42773
ENSG00000123080ENST00000262662Q6ICV4
ENSG00000123080ENST00000371761P42773
ENSG00000123080ENST00000371761Q6ICV4
ENSG00000123080ENST00000396148P42773
ENSG00000123080ENST00000396148Q6ICV4

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226852902012Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18.148
162604942005The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.72
191415852009Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states.70
183945582008Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.64
205073462010The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes.48
174094092007Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.47
219944152011Mapping of chromosome 1p deletions in myeloma identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as being genes in regions associated with adverse survival.45
194110682009CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.43
120771442002Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1.30
188294822008Deletions of CDKN2C in multiple myeloma: biological and clinical implications.27

Citation

Dessen P

CDKN2C (cyclin dependent kinase inhibitor 2C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/190/cdkn2c