CLDN8 (claudin 8)

2007-11-01  

Identity

HGNC
LOCATION
21q22.11
LOCUSID
ALIAS
HEL-S-79

Other Information

Locus ID:

NCBI: 9073
MIM: 611231
HGNC: 2050
Ensembl: ENSG00000156284

Variants:

dbSNP: 9073
ClinVar: 9073
TCGA: ENSG00000156284
COSMIC: CLDN8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156284ENST00000399899P56748
ENSG00000156284ENST00000399899A0A0K0K1I9

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
270294862016Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease.32
170479702007Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12.30
190006572009Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation.28
127367072003CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.23
233226402013Human claudin-8 and -14 are receptors capable of conveying the cytotoxic effects of Clostridium perfringens enterotoxin.23
187991952009Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.13
284748052017CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration.10
299011882018Differences in the expression profiles of claudin proteins in human gastric carcinoma compared with non‑neoplastic mucosa.8
264647082015Expression of claudin-5, -7, -8 and -9 in cervical carcinoma tissues and adjacent non-neoplastic tissues.6
281387552017Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and -8.6

Citation

Dessen P

CLDN8 (claudin 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49807/cldn8