CRKL (v-crk sarcoma virus CT10 oncogene homolog (avian)-like)

Identity

Other names	-
HGNC	CRKL
Location	22q11.21
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CRKL   2363
Entrez_Gene	CRKL  1399  v-crk sarcoma virus CT10 oncogene homolog (avian)-like
	Cards
GeneCards	CRKL
Ensembl	CRKL [Search_View]   ENSG00000099942 [Gene_View]
Genatlas	CRKL
GeneLynx	CRKL
eGenome	CRKL
euGene	1399
	Genomic and cartography
GoldenPath	CRKL  -  22q11.21   chr22:19601714-19637890 +  22q11.21   [Description]    (hg18-March_2006)
Ensembl	CRKL - 22q11.21 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CRKL
	Gene and transcription
Genbank	AK000311 [ ENTREZ ]
Genbank	AK292909 [ ENTREZ ]
Genbank	BC026248 [ ENTREZ ]
Genbank	BC033281 [ ENTREZ ]
Genbank	BC043500 [ ENTREZ ]
RefSeq	NM_005207 [ SRS ]    NM_005207 [ ENTREZ ]
RefSeq	AC_000065 [ SRS ]    AC_000065 [ ENTREZ ]
RefSeq	AC_000154 [ SRS ]    AC_000154 [ ENTREZ ]
RefSeq	NC_000022 [ SRS ]    NC_000022 [ ENTREZ ]
RefSeq	NT_011520 [ SRS ]    NT_011520 [ ENTREZ ]
RefSeq	NW_001838740 [ SRS ]    NW_001838740 [ ENTREZ ]
RefSeq	NW_927495 [ SRS ]    NW_927495 [ ENTREZ ]
AceView	CRKL AceView - NCBI
Unigene	Hs.592205 [ SRS ]    Hs.592205 [ NCBI ]     HS592205 [ spliceNest ]
Fast-db	1911 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P46109 [ SRS]    P46109 [ EXPASY ]     P46109 [ INTERPRO ]     P46109 [ UNIPROT ]
Prosite	PS50001 SH2 [ SRS ]    PS50001 SH2 [ Expasy ]
Prosite	PS50002 SH3 [ SRS ]    PS50002 SH3 [ Expasy ]
Interpro	IPR000980 SH2 [ SRS ]    IPR000980 SH2 [ EBI ]
Interpro	IPR001452 SH3 [ SRS ]    IPR001452 SH3 [ EBI ]
Interpro	IPR011511 SH3_2 [ SRS ]    IPR011511 SH3_2 [ EBI ]
CluSTr	P46109
Pfam	PF00017 SH2 [ SRS ]    PF00017 SH2 [ Sanger ]    pfam00017 [ NCBI-CDD ]
Pfam	PF00018 SH3_1 [ SRS ]    PF00018 SH3_1 [ Sanger ]    pfam00018 [ NCBI-CDD ]
Pfam	PF07653 SH3_2 [ SRS ]    PF07653 SH3_2 [ Sanger ]    pfam07653 [ NCBI-CDD ]
Smart	SM00252 SH2 [EMBL]
Smart	SM00326 SH3 [EMBL]
Prodom	PD000093 SH2[INRA-Toulouse]
Prodom	P46109 CRKL_HUMAN [ Domain structure ]   P46109 CRKL_HUMAN  [ sequences sharing at least 1 domain ]
Prodom	PD000093[INRA-Toulouse]
Prodom	P46109 CRKL_HUMAN [ Domain structure ]   P46109 CRKL_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P46109
PDB	2BZX [ SRS ]    2BZX [ PdbSum ],   2BZX [ IMB ]   2BZX [ RSDB ]
PDB	2BZY [ SRS ]    2BZY [ PdbSum ],   2BZY [ IMB ]   2BZY [ RSDB ]
PDB	2DBK [ SRS ]    2DBK [ PdbSum ],   2DBK [ IMB ]   2DBK [ RSDB ]
PDB	2EO3 [ SRS ]    2EO3 [ PdbSum ],   2EO3 [ IMB ]   2EO3 [ RSDB ]
HPRD	03596
	Protein Interaction databases
DIP	P46109
IntAct	P46109
	Polymorphism : SNP, mutations, diseases
OMIM	602007    [ map ]
GENECLINICS	602007
SNP	CRKL [dbSNP-NCBI]
SNP	NM_005207 [SNP-NCI]
SNP	CRKL [GeneSNPs - Utah]  CRKL] [HGBASE - SRS]
HAPMAP	CRKL [HAPMAP]
COSMIC	CRKL [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	CRKL
	General knowledge
Family Browser	CRKL [UCSC Family Browser]
SOURCE	NM_005207
SMD	Hs.592205
SAGE	Hs.592205
GO	blood vessel development [Amigo]  blood vessel development
GO	protein tyrosine kinase activity [Amigo]  protein tyrosine kinase activity
GO	SH3/SH2 adaptor activity [Amigo]  SH3/SH2 adaptor activity
GO	protein binding [Amigo]  protein binding
GO	intracellular signaling cascade [Amigo]  intracellular signaling cascade
GO	JNK cascade [Amigo]  JNK cascade
GO	Ras protein signal transduction [Amigo]  Ras protein signal transduction
GO	pattern specification process [Amigo]  pattern specification process
GO	heart development [Amigo]  heart development
GO	organ morphogenesis [Amigo]  organ morphogenesis
GO	anterior/posterior pattern formation [Amigo]  anterior/posterior pattern formation
GO	thymus development [Amigo]  thymus development
GO	parathyroid gland development [Amigo]  parathyroid gland development
BIOCARTA	Inhibition of Cellular Proliferation by Gleevec    [Genes]
BIOCARTA	IL-2 Receptor Beta Chain in T cell Activation    [Genes]
BIOCARTA	Integrin Signaling Pathway    [Genes]
BIOCARTA	Signaling of Hepatocyte Growth Factor Receptor    [Genes]
BIOCARTA	Links between Pyk2 and Map Kinases    [Genes]
KEGG	MAPK signaling pathway
KEGG	Focal adhesion
KEGG	Regulation of actin cytoskeleton
KEGG	Insulin signaling pathway
PubGene	CRKL
TreeFam	CRKL
CTD	1399 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CRKL Related clones (RZPD - Berlin)
	PubMed
PubMed	86 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:06:08 2008