CYBB (cytochrome b-245, beta polypeptide (chronic granulomatous disease))

Identity

Other names	CGD
	GP91-1
	GP91-PHOX
	GP91PHOX
	NOX2
	p91-PHOX
Hugo	CYBB
Location	Xp21.1
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	CYBB
GDB	CYBB
Entrez_Gene	CYBB  1536  cytochrome b-245, beta polypeptide (chronic granulomatous disease)
	Cards
GeneCards	CYBB
Ensembl	CYBB [Search_View]   ENSG00000165168 [Gene_View]
Genatlas	CYBB
GeneLynx	CYBB
eGenome	CYBB
euGene	1536
	Genomic and cartography
GoldenPath	CYBB  -  Xp21.1   chrX:37524214-37557658 +  Xp11.4   [Description]    (hg18-March_2006)
Ensembl	CYBB - Xp11.4 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CYBB
	Gene and transcription
Genbank	AK289753 [ ENTREZ ]
Genbank	AK312929 [ ENTREZ ]
Genbank	BC032720 [ ENTREZ ]
Genbank	CR601230 [ ENTREZ ]
Genbank	CR622452 [ ENTREZ ]
RefSeq	NM_000397 [ SRS ]    NM_000397 [ ENTREZ ]
RefSeq	AC_000066 [ SRS ]    AC_000066 [ ENTREZ ]
RefSeq	AC_000155 [ SRS ]    AC_000155 [ ENTREZ ]
RefSeq	NC_000023 [ SRS ]    NC_000023 [ ENTREZ ]
RefSeq	NT_079573 [ SRS ]    NT_079573 [ ENTREZ ]
RefSeq	NW_001842361 [ SRS ]    NW_001842361 [ ENTREZ ]
RefSeq	NW_927701 [ SRS ]    NW_927701 [ ENTREZ ]
AceView	CYBB AceView - NCBI
Unigene	Hs.292356 [ SRS ]    Hs.292356 [ NCBI ]     HS292356 [ spliceNest ]
Fast-db	5667 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P04839 [ SRS]    P04839 [ EXPASY ]     P04839 [ INTERPRO ]
Prosite	PS51384 FAD_FR [ SRS ]    PS51384 FAD_FR [ Expasy ]
Interpro	IPR013112 FAD_bd_8 [ SRS ]    IPR013112 FAD_bd_8 [ EBI ]
Interpro	IPR013130 Fe3_reduct_TM_N [ SRS ]    IPR013130 Fe3_reduct_TM_N [ EBI ]
Interpro	IPR013121 Fe_red_NAD_bd_6 [ SRS ]    IPR013121 Fe_red_NAD_bd_6 [ EBI ]
Interpro	IPR000778 GP91PhoX [ SRS ]    IPR000778 GP91PhoX [ EBI ]
CluSTr	P04839
Pfam	PF08022 FAD_binding_8 [ SRS ]    PF08022 FAD_binding_8 [ Sanger ]    pfam08022 [ NCBI-CDD ]
Pfam	PF01794 Ferric_reduct [ SRS ]    PF01794 Ferric_reduct [ Sanger ]    pfam01794 [ NCBI-CDD ]
Pfam	PF08030 NAD_binding_6 [ SRS ]    PF08030 NAD_binding_6 [ Sanger ]    pfam08030 [ NCBI-CDD ]
Blocks	P04839
PDB	CYBB [ SRS ]    CYBB [ PdbSum ],   CYBB [ IMB ]   CYBB [ RSDB ]
HPRD	02382
	Protein Interaction databases
DIP	P04839
IntAct	P04839
	Polymorphism : SNP, mutations, diseases
OMIM	300481;306400    [ map ]
GENECLINICS	300481;306400
SNP	CYBB [dbSNP-NCBI]
SNP	NM_000397 [SNP-NCI]
SNP	CYBB [GeneSNPs - Utah]  CYBB] [HGBASE - SRS]
HAPMAP	CYBB [HAPMAP]
COSMIC	CYBB [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	CYBB
	General knowledge
Family Browser	CYBB [UCSC Family Browser]
SOURCE	NM_000397
SMD	Hs.292356
SAGE	Hs.292356
GO	voltage-gated ion channel activity [Amigo]  voltage-gated ion channel activity
GO	iron ion binding [Amigo]  iron ion binding
GO	cytoplasm [Amigo]  cytoplasm
GO	plasma membrane [Amigo]  plasma membrane
GO	ion transport [Amigo]  ion transport
GO	inflammatory response [Amigo]  inflammatory response
GO	electron carrier activity [Amigo]  electron carrier activity
GO	superoxide-generating NADPH oxidase activity [Amigo]  superoxide-generating NADPH oxidase activity
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	superoxide release [Amigo]  superoxide release
GO	NADPH oxidase complex [Amigo]  NADPH oxidase complex
GO	innate immune response [Amigo]  innate immune response
GO	respiratory burst [Amigo]  respiratory burst
GO	metal ion binding [Amigo]  metal ion binding
GO	FAD binding [Amigo]  FAD binding
GO	oxidation reduction [Amigo]  oxidation reduction
KEGG	Leukocyte transendothelial migration
PubGene	CYBB
TreeFam	CYBB
CTD	1536 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CYBB Related clones (RZPD - Berlin)
	PubMed
PubMed	78 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Jul 14 17:03:54 2008