DAAM1 (dishevelled associated activator of morphogenesis 1)

2012-10-01  

Identity

HGNC
LOCATION
14q23.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 23002
MIM: 606626
HGNC: 18142
Ensembl: ENSG00000100592

Variants:

dbSNP: 23002
ClinVar: 23002
TCGA: ENSG00000100592
COSMIC: DAAM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100592ENST00000360909Q9Y4D1
ENSG00000100592ENST00000395125Q9Y4D1
ENSG00000100592ENST00000556135G3V275

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
181625512008Mechanism of activation of the Formin protein Daam1.74
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
170210342006Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation.44
226550722012Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration.42
166306112006The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics.40
174822082007Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly.37
203512932010Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis.30
209273662010DAAM1 is a formin required for centrosome re-orientation during cell migration.28
182186252008Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets.26
202238272010Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase.21

Citation

Dessen P

DAAM1 (dishevelled associated activator of morphogenesis 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52902/daam1