DCLRE1B (DNA cross-link repair 1B)

2003-12-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
APOLLO,SNM1B,SNMIB

Other Information

Locus ID:

NCBI: 64858
MIM: 609683
HGNC: 17641
Ensembl: ENSG00000118655

Variants:

dbSNP: 64858
ClinVar: 64858
TCGA: ENSG00000118655
COSMIC: DCLRE1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118655ENST00000466480A0A3B3IT16
ENSG00000118655ENST00000648795A0A3B3IT16
ENSG00000118655ENST00000650450Q9H816
ENSG00000118655ENST00000650596A0A3B3ITQ0

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310

References

Pubmed IDYearTitleCitations
206554662010TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.78
167301762006Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase.72
167301752006The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair.67
154677582004Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation.34
184698622008Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links.33
226922012012Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.21
166066222006hSnm1B is a novel telomere-associated protein.20
184689652008Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.16
191971582009SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint.12
238634622013The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.12

Citation

Dessen P

DCLRE1B (DNA cross-link repair 1B)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40272/dclre1b