DDB1 (damage specific DNA binding protein 1)

2003-02-01  

Identity

HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
DDBA,UV-DDB1,XAP1,XPCE,XPE,XPE-BF
FUSION GENES

Other Information

Locus ID:

NCBI: 1642
MIM: 600045
HGNC: 2717
Ensembl: ENSG00000167986

Variants:

dbSNP: 1642
ClinVar: 1642
TCGA: ENSG00000167986
COSMIC: DDB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167986ENST00000301764Q16531
ENSG00000167986ENST00000535283F5GWI0
ENSG00000167986ENST00000539426F5H2L3
ENSG00000167986ENST00000540166F5GY55
ENSG00000167986ENST00000542337F5GZY8
ENSG00000167986ENST00000543627F5GYG8
ENSG00000167986ENST00000543658F5H198

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Nucleotide excision repairKEGGko03420
Ubiquitin mediated proteolysisKEGGko04120
Nucleotide excision repairKEGGhsa03420
Ubiquitin mediated proteolysisKEGGhsa04120
Cul4-DDB1-DDB2 complexKEGGhsa_M00385
Cul4-DDB1-CSA complexKEGGhsa_M00386
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
Cul4-DDB1-DDB2 complexKEGGM00385
Cul4-DDB1-CSA complexKEGGM00386
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Recognition of DNA damage by PCNA-containing replication complexREACTOMER-HSA-110314
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
Dual Incision in GG-NERREACTOMER-HSA-5696400
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169493672006A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.300
169642402006Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.279
166781102006Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.196
250430122014Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.174
198186322009CRL4s: the CUL4-RING E3 ubiquitin ligases.161
191098932008Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.156
170796842006DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.154
164739352006The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.142
147394642004Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.139
176093812007Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.125

Citation

Dessen P

DDB1 (damage specific DNA binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40278/ddb1