DSTN (destrin, actin depolymerizing factor)

2007-12-01  

Identity

HGNC
DSTN
LOCATION
20p12.1
LOCUSID
11034
ALIAS
ACTDP,ADF,HEL32,bA462D18.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11034
MIM: 609114
HGNC: 15750
Ensembl: ENSG00000125868

Variants:

dbSNP: 11034
ClinVar: 11034
TCGA: ENSG00000125868
COSMIC: DSTN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125868ENST00000246069P60981
ENSG00000125868ENST00000246069V9HWA6
ENSG00000125868ENST00000449141F6RFD5
ENSG00000125868ENST00000474024P60981

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208352502010ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity.118
146277012004Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor.54
118121572002Determining the differences in actin binding by human ADF and cofilin.53
215712222011ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1.34
175835722007Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells.15
269969392016TIRF microscopy analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover.14
171962182007Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin.13
158168412005Proteomic profiling identifies an UV-induced activation of cofilin-1 and destrin in human epidermis.5
228986372012The actin binding protein destrin is associated with growth and perineural invasion of pancreatic cancer.5
208739702010A study of the expression and interaction of Destrin, cofilin, and LIMK in Debakey I type thoracic aortic dissection tissue.4

Citation

Dessen P

DSTN (destrin, actin depolymerizing factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49860/dstn