DUOX2 (dual oxidase 2)

Identity

Other names	LNOX2
	NOXEF2
	P138-TOX
	THOX2
Hugo	DUOX2
Location	15q15.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	DUOX2
GDB	DUOX2
Entrez_Gene	DUOX2  50506  dual oxidase 2
	Cards
GeneCards	DUOX2
Ensembl	DUOX2 [Search_View]   ENSG00000140279 [Gene_View]
Genatlas	DUOX2
GeneLynx	DUOX2
eGenome	DUOX2
euGene	50506
	Genomic and cartography
GoldenPath	DUOX2  -  15q15.3   chr15:43172144-43193651 -  15q21.1   [Description]    (hg18-March_2006)
Ensembl	DUOX2 - 15q21.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	DUOX2
	Gene and transcription
Genbank	AB209010 [ ENTREZ ]
Genbank	AF181972 [ ENTREZ ]
Genbank	AF230496 [ ENTREZ ]
Genbank	AF267981 [ ENTREZ ]
Genbank	BI045475 [ ENTREZ ]
RefSeq	NM_014080 [ SRS ]    NM_014080 [ ENTREZ ]
RefSeq	AC_000058 [ SRS ]    AC_000058 [ ENTREZ ]
RefSeq	NC_000015 [ SRS ]    NC_000015 [ ENTREZ ]
RefSeq	NT_010194 [ SRS ]    NT_010194 [ ENTREZ ]
RefSeq	NW_925884 [ SRS ]    NW_925884 [ ENTREZ ]
AceView	DUOX2 AceView - NCBI
Unigene	Hs.71377 [ SRS ]    Hs.71377 [ NCBI ]     HS71377 [ spliceNest ]
Fast-db	4414 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9NRD8 [ SRS]    Q9NRD8 [ EXPASY ]     Q9NRD8 [ INTERPRO ]
Prosite	PS00018 EF_HAND_1 [ SRS ]    PS00018 EF_HAND_1 [ Expasy ]
Prosite	PS50222 EF_HAND_2 [ SRS ]    PS50222 EF_HAND_2 [ Expasy ]
Prosite	PS50292 PEROXIDASE_3 [ SRS ]    PS50292 PEROXIDASE_3 [ Expasy ]
Interpro	IPR011992 EF-Hand_type [ SRS ]    IPR011992 EF-Hand_type [ EBI ]
Interpro	IPR002048 EF_hand_Ca_bd [ SRS ]    IPR002048 EF_hand_Ca_bd [ EBI ]
Interpro	IPR013112 FAD_bd_8 [ SRS ]    IPR013112 FAD_bd_8 [ EBI ]
Interpro	IPR013130 Fe3_reduct_TM_N [ SRS ]    IPR013130 Fe3_reduct_TM_N [ EBI ]
Interpro	IPR013121 Fe_red_NAD_bd_6 [ SRS ]    IPR013121 Fe_red_NAD_bd_6 [ EBI ]
Interpro	IPR002007 Haem_peroxidase_animal [ SRS ]    IPR002007 Haem_peroxidase_animal [ EBI ]
Interpro	IPR001125 Recoverin [ SRS ]    IPR001125 Recoverin [ EBI ]
CluSTr	Q9NRD8
Pfam	PF03098 An_peroxidase [ SRS ]    PF03098 An_peroxidase [ Sanger ]    pfam03098 [ NCBI-CDD ]
Pfam	PF00036 efhand [ SRS ]    PF00036 efhand [ Sanger ]    pfam00036 [ NCBI-CDD ]
Pfam	PF08022 FAD_binding_8 [ SRS ]    PF08022 FAD_binding_8 [ Sanger ]    pfam08022 [ NCBI-CDD ]
Pfam	PF01794 Ferric_reduct [ SRS ]    PF01794 Ferric_reduct [ Sanger ]    pfam01794 [ NCBI-CDD ]
Pfam	PF08030 NAD_binding_6 [ SRS ]    PF08030 NAD_binding_6 [ Sanger ]    pfam08030 [ NCBI-CDD ]
Smart	SM00054 EFh [EMBL]
Prodom	PD000012 EF-hand[INRA-Toulouse]
Prodom	Q9NRD8 DUOX2_HUMAN [ Domain structure ]   Q9NRD8 DUOX2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q9NRD8
HPRD	05997
	Protein Interaction databases
DIP	Q9NRD8
IntAct	Q9NRD8
	Polymorphism : SNP, mutations, diseases
OMIM	606759;607200    [ map ]
GENECLINICS	606759;607200
SNP	DUOX2 [dbSNP-NCBI]
SNP	NM_014080 [SNP-NCI]
SNP	DUOX2 [GeneSNPs - Utah]  DUOX2] [HGBASE - SRS]
HAPMAP	DUOX2 [HAPMAP]
HGMD	DUOX2
	General knowledge
Family Browser	DUOX2 [UCSC Family Browser]
SOURCE	NM_014080
SMD	Hs.71377
SAGE	Hs.71377
Enzyme	1.6.3.1 [ Enzyme-SRS ]   1.6.3.1 [ Brenda-SRS ]   1.6.3.1 [ KEGG ]   1.6.3.1 [ WIT ]
GO	peroxidase activity [Amigo]  peroxidase activity
GO	iron ion binding [Amigo]  iron ion binding
GO	calcium ion binding [Amigo]  calcium ion binding
GO	calcium ion binding [Amigo]  calcium ion binding
GO	electron transport [Amigo]  electron transport
GO	electron transport [Amigo]  electron transport
GO	response to oxidative stress [Amigo]  response to oxidative stress
GO	response to virus [Amigo]  response to virus
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	NAD(P)H oxidase activity [Amigo]  NAD(P)H oxidase activity
GO	apical plasma membrane [Amigo]  apical plasma membrane
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	cytokine and chemokine mediated signaling pathway [Amigo]  cytokine and chemokine mediated signaling pathway
GO	cytokine and chemokine mediated signaling pathway [Amigo]  cytokine and chemokine mediated signaling pathway
GO	heme binding [Amigo]  heme binding
GO	cuticle development [Amigo]  cuticle development
GO	hormone biosynthetic process [Amigo]  hormone biosynthetic process
GO	hydrogen peroxide catabolic process [Amigo]  hydrogen peroxide catabolic process
GO	FAD binding [Amigo]  FAD binding
GO	response to cAMP [Amigo]  response to cAMP
GO	response to cAMP [Amigo]  response to cAMP
PubGene	DUOX2
TreeFam	DUOX2
CTD	50506 [Comparative Genomics Database]
	Other databases
	Probes
Probe	DUOX2 Related clones (RZPD - Berlin)
	PubMed
PubMed	25 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 20:04:35 2008