DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3)

2006-10-01  

Identity

HGNC
DYRK3
LOCATION
1q32.1
LOCUSID
8444
ALIAS
DYRK5,RED,REDK,hYAK3-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8444
MIM: 603497
HGNC: 3094
Ensembl: ENSG00000143479

Variants:

dbSNP: 8444
ClinVar: 8444
TCGA: ENSG00000143479
COSMIC: DYRK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143479ENST00000367106O43781
ENSG00000143479ENST00000367108O43781
ENSG00000143479ENST00000367109O43781
ENSG00000143479ENST00000441486Q5SY34
ENSG00000143479ENST00000649163A0A3B3ISB2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
234152272013Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.140
201676032010DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.88
299737242018Kinase-controlled phase transition of membraneless organelles in mitosis.37
216937042011Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3).32
123567712002DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival.12
188543062008DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.8
156074272005DYRK gene structure and erythroid-restricted features of DYRK3 gene expression.4
296349192018Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylation.2

Citation

Dessen P

DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43237/dyrk3