E2F8 (E2F transcription factor 8)

2010-03-01  

Identity

HGNC
E2F8
LOCATION
11p15.1
LOCUSID
79733
ALIAS
E2F-8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79733
MIM: 612047
HGNC: 24727
Ensembl: ENSG00000129173

Variants:

dbSNP: 79733
ClinVar: 79733
TCGA: ENSG00000129173
COSMIC: E2F8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129173ENST00000250024A0AVK6
ENSG00000129173ENST00000527884A0AVK6
ENSG00000129173ENST00000532666E9PMT9
ENSG00000129173ENST00000620009A0AVK6

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
thymus
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
161796492005Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.63
182027192008DNA-damage response control of E2F7 and E2F8.63
230642642012E2F8 is essential for polyploidization in mammalian cells.56
158978862005E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7.52
260895412015E2F8 as a Novel Therapeutic Target for Lung Cancer.34
200681562010E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation.32
282702282017E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle.21
274542912016E2f8 mediates tumor suppression in postnatal liver development.20
269922242016Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition.19
301441842018Upregulated miR-1258 regulates cell cycle and inhibits cell proliferation by directly targeting E2F8 in CRC.11

Citation

Dessen P

E2F8 (E2F transcription factor 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51400/e2f8