EDN1 (endothelin 1)

Identity

Other names	ET1
	HDLCQ7
HGNC	EDN1
Location	6p24.1
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	EDN1   3176
Entrez_Gene	EDN1  1906  endothelin 1
	Cards
GeneCards	EDN1
Ensembl	EDN1 [Search_View]   ENSG00000078401 [Gene_View]
Genatlas	EDN1
GeneLynx	EDN1
eGenome	EDN1
euGene	1906
	Genomic and cartography
GoldenPath	EDN1  -  6p24.1   chr6:12398515-12405413 +  6p24.1   [Description]    (hg18-March_2006)
Ensembl	EDN1 - 6p24.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	EDN1
	Gene and transcription
Genbank	AK226096 [ ENTREZ ]
Genbank	AK291838 [ ENTREZ ]
Genbank	AK313914 [ ENTREZ ]
Genbank	BC009720 [ ENTREZ ]
Genbank	BC036851 [ ENTREZ ]
RefSeq	NM_001955 [ SRS ]    NM_001955 [ ENTREZ ]
RefSeq	AC_000049 [ SRS ]    AC_000049 [ ENTREZ ]
RefSeq	AC_000138 [ SRS ]    AC_000138 [ ENTREZ ]
RefSeq	NC_000006 [ SRS ]    NC_000006 [ ENTREZ ]
RefSeq	NT_007592 [ SRS ]    NT_007592 [ ENTREZ ]
RefSeq	NW_001838973 [ SRS ]    NW_001838973 [ ENTREZ ]
RefSeq	NW_922984 [ SRS ]    NW_922984 [ ENTREZ ]
AceView	EDN1 AceView - NCBI
Unigene	Hs.713645 [ SRS ]    Hs.713645 [ NCBI ]     HS713645 [ spliceNest ]
Fast-db	2472 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P05305 [ SRS]    P05305 [ EXPASY ]     P05305 [ INTERPRO ]     P05305 [ UNIPROT ]
Prosite	PS00270 ENDOTHELIN [ SRS ]    PS00270 ENDOTHELIN [ Expasy ]
Interpro	IPR001928 Endothln_tox [ SRS ]    IPR001928 Endothln_tox [ EBI ]
CluSTr	P05305
Pfam	PF00322 Endothelin [ SRS ]    PF00322 Endothelin [ Sanger ]    pfam00322 [ NCBI-CDD ]
Smart	SM00272 END [EMBL]
Prodom	PD005286 Endothelin[INRA-Toulouse]
Prodom	P05305 EDN1_HUMAN [ Domain structure ]   P05305 EDN1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P05305
PDB	1EDN [ SRS ]    1EDN [ PdbSum ],   1EDN [ IMB ]   1EDN [ RSDB ]
PDB	1EDP [ SRS ]    1EDP [ PdbSum ],   1EDP [ IMB ]   1EDP [ RSDB ]
PDB	1T7H [ SRS ]    1T7H [ PdbSum ],   1T7H [ IMB ]   1T7H [ RSDB ]
PDB	1V6R [ SRS ]    1V6R [ PdbSum ],   1V6R [ IMB ]   1V6R [ RSDB ]
HPRD	07030
	Protein Interaction databases
DIP	P05305
IntAct	P05305
	Polymorphism : SNP, mutations, diseases
OMIM	131240    [ map ]
GENECLINICS	131240
SNP	EDN1 [dbSNP-NCBI]
SNP	NM_001955 [SNP-NCI]
SNP	EDN1 [GeneSNPs - Utah]  EDN1] [HGBASE - SRS]
HAPMAP	EDN1 [HAPMAP]
HGMD	EDN1
	General knowledge
Family Browser	EDN1 [UCSC Family Browser]
SOURCE	NM_001955
SMD	Hs.713645
SAGE	Hs.713645
GO	patterning of blood vessels [Amigo]  patterning of blood vessels
GO	response to hypoxia [Amigo]  response to hypoxia
GO	in utero embryonic development [Amigo]  in utero embryonic development
GO	hormone activity [Amigo]  hormone activity
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	cytoplasm [Amigo]  cytoplasm
GO	regulation of pH [Amigo]  regulation of pH
GO	activation of protein kinase C activity [Amigo]  activation of protein kinase C activity
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	heart development [Amigo]  heart development
GO	respiratory gaseous exchange [Amigo]  respiratory gaseous exchange
GO	regulation of blood pressure [Amigo]  regulation of blood pressure
GO	dorsal/ventral pattern formation [Amigo]  dorsal/ventral pattern formation
GO	neural crest cell development [Amigo]  neural crest cell development
GO	phosphoinositide 3-kinase cascade [Amigo]  phosphoinositide 3-kinase cascade
GO	glucose transport [Amigo]  glucose transport
GO	regulation of vasoconstriction [Amigo]  regulation of vasoconstriction
GO	calcium-mediated signaling [Amigo]  calcium-mediated signaling
GO	peptide hormone secretion [Amigo]  peptide hormone secretion
GO	diuresis [Amigo]  diuresis
GO	natriuresis [Amigo]  natriuresis
GO	nitric oxide transport [Amigo]  nitric oxide transport
GO	negative regulation of blood coagulation [Amigo]  negative regulation of blood coagulation
GO	negative regulation of cAMP biosynthetic process [Amigo]  negative regulation of cAMP biosynthetic process
GO	G-protein signaling, phospholipase D activating pathway [Amigo]  G-protein signaling, phospholipase D activating pathway
GO	endothelin A receptor binding [Amigo]  endothelin A receptor binding
GO	endothelin B receptor binding [Amigo]  endothelin B receptor binding
GO	protein kinase C deactivation [Amigo]  protein kinase C deactivation
GO	middle ear morphogenesis [Amigo]  middle ear morphogenesis
GO	rhythmic excitation [Amigo]  rhythmic excitation
GO	positive regulation of JNK activity [Amigo]  positive regulation of JNK activity
GO	leukocyte activation [Amigo]  leukocyte activation
GO	positive regulation of cell size [Amigo]  positive regulation of cell size
GO	positive regulation of mitosis [Amigo]  positive regulation of mitosis
GO	positive regulation of hormone secretion [Amigo]  positive regulation of hormone secretion
GO	negative regulation of hormone secretion [Amigo]  negative regulation of hormone secretion
GO	blood vessel morphogenesis [Amigo]  blood vessel morphogenesis
GO	positive regulation of smooth muscle cell proliferation [Amigo]  positive regulation of smooth muscle cell proliferation
GO	cartilage development [Amigo]  cartilage development
GO	elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) [Amigo]  elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
GO	negative regulation of nitric-oxide synthase biosynthetic process [Amigo]  negative regulation of nitric-oxide synthase biosynthetic process
GO	membrane depolarization [Amigo]  membrane depolarization
BIOCARTA	Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy    [Genes]
BIOCARTA	Hypoxia-Inducible Factor in the Cardiovascular System    [Genes]
BIOCARTA	NFAT and Hypertrophy of the heart (Transcription in the broken heart)    [Genes]
KEGG	Neuroactive ligand-receptor interaction
PubGene	EDN1
TreeFam	EDN1
CTD	1906 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	EDN1 Related clones (RZPD - Berlin)
	PubMed
PubMed	261 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:09:02 2008