EED (embryonic ectoderm development)

2007-04-01 Affiliation

Identity

HGNC

EED

LOCATION

11q14.2

LOCUSID

8726

ALIAS

COGIS,HEED,WAIT1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8726
MIM: 605984
HGNC: 3188
Ensembl: ENSG00000074266

Variants:

dbSNP: 8726
ClinVar: 8726
TCGA: ENSG00000074266
COSMIC: EED

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000074266	ENST00000263360	O75530
ENSG00000074266	ENST00000327320	O75530
ENSG00000074266	ENST00000351625	O75530
ENSG00000074266	ENST00000527888	E9PMU3
ENSG00000074266	ENST00000528180	E9PJK2
ENSG00000074266	ENST00000534595	H0YEL4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
PRC2 methylates histones and DNA	REACTOME	R-HSA-212300
Developmental Biology	REACTOME	R-HSA-1266738
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
PKMTs methylate histone lysines	REACTOME	R-HSA-3214841
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19767730	2009	Role of the polycomb protein EED in the propagation of repressive histone marks.	402
25240281	2014	PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.	127
20974918	2010	Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).	67
24320048	2013	Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins.	62
24457600	2014	The central role of EED in the orchestration of polycomb group complexes.	44
14759364	2004	HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane.	29
25326896	2015	Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer.	25
29754954	2018	The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.	18
21540835	2011	Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation.	17
28229514	2017	Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome.	17

Citation

Dessen P

EED (embryonic ectoderm development)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47375/eed