EFNA1 (ephrin A1)

2003-06-01  

Identity

HGNC
LOCATION
1q22
LOCUSID
ALIAS
B61,ECKLG,EFL1,EPLG1,GMAN,LERK-1,LERK1,TNFAIP4
FUSION GENES

Other Information

Locus ID:

NCBI: 1942
MIM: 191164
HGNC: 3221
Ensembl: ENSG00000169242

Variants:

dbSNP: 1942
ClinVar: 1942
TCGA: ENSG00000169242
COSMIC: EFNA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169242ENST00000368406P20827
ENSG00000169242ENST00000368407P20827

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190748252008The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting.114
124963642002Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis.85
124963712002c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.61
187947972008Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor.55
195259192009Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.52
304450102019Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS.42
164284722006Expression of EphA2 and Ephrin A-1 in carcinoma of the urinary bladder.41
156492542005EPHA2/EFNA1 expression in human gastric cancer.38
220409112012Ephs and ephrins in cancer: ephrin-A1 signalling.38
160516092005EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase.33

Citation

Dessen P

EFNA1 (ephrin A1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40412/efna1