EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2)

Identity

Other names	EIF2AK1
	MGC126524
	PKR
	PRKR
HGNC	EIF2AK2
Location	2p22-p21
Location_base_pair	Starts at 37187203 and ends at 37229907 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	EIF2AK2   9437
Entrez_Gene	EIF2AK2  5610  eukaryotic translation initiation factor 2-alpha kinase 2
	Cards
GeneCards	EIF2AK2
Ensembl	EIF2AK2 [Search_View]   ENSG00000055332 [Gene_View]
Genatlas	EIF2AK2
GeneLynx	EIF2AK2
eGenome	EIF2AK2
euGene	5610
	Genomic and cartography
GoldenPath	EIF2AK2  -     chr2:37187203-37229907 -  2p22.2   [Description]    (hg18-March_2006)
Ensembl	EIF2AK2 - 2p22.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	EIF2AK2
	Gene and transcription
Genbank	AF086566 [ ENTREZ ]
Genbank	AK290655 [ ENTREZ ]
Genbank	AK313818 [ ENTREZ ]
Genbank	AY302136 [ ENTREZ ]
Genbank	BC007769 [ ENTREZ ]
RefSeq	NM_002759 [ SRS ]    NM_002759 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_022184 [ SRS ]    NT_022184 [ ENTREZ ]
RefSeq	NW_001838769 [ SRS ]    NW_001838769 [ ENTREZ ]
RefSeq	NW_927719 [ SRS ]    NW_927719 [ ENTREZ ]
AceView	EIF2AK2 AceView - NCBI
Unigene	Hs.131431 [ SRS ]    Hs.131431 [ NCBI ]     HS131431 [ spliceNest ]
Fast-db	4054 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P19525 [ SRS]    P19525 [ EXPASY ]     P19525 [ INTERPRO ]     P19525 [ UNIPROT ]
Prosite	PS50137 DS_RBD [ SRS ]    PS50137 DS_RBD [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR001159 Ds_RNA_bd [ SRS ]    IPR001159 Ds_RNA_bd [ EBI ]
Interpro	IPR014720 dsRNA-bd-like [ SRS ]    IPR014720 dsRNA-bd-like [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
CluSTr	P19525
Pfam	PF00035 dsrm [ SRS ]    PF00035 dsrm [ Sanger ]    pfam00035 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00358 DSRM [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P19525 E2AK2_HUMAN [ Domain structure ]   P19525 E2AK2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P19525
PDB	1QU6 [ SRS ]    1QU6 [ PdbSum ],   1QU6 [ IMB ]   1QU6 [ RSDB ]
PDB	2A19 [ SRS ]    2A19 [ PdbSum ],   2A19 [ IMB ]   2A19 [ RSDB ]
PDB	2A1A [ SRS ]    2A1A [ PdbSum ],   2A1A [ IMB ]   2A1A [ RSDB ]
HPRD	01468
	Protein Interaction databases
DIP	P19525
IntAct	P19525
	Polymorphism : SNP, mutations, diseases
OMIM	176871    [ map ]
GENECLINICS	176871
SNP	EIF2AK2 [dbSNP-NCBI]
SNP	NM_002759 [SNP-NCI]
SNP	EIF2AK2 [GeneSNPs - Utah]  EIF2AK2] [HGBASE - SRS]
HAPMAP	EIF2AK2 [HAPMAP]
COSMIC	EIF2AK2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	EIF2AK2
	General knowledge
Family Browser	EIF2AK2 [UCSC Family Browser]
SOURCE	NM_002759
SMD	Hs.131431
SAGE	Hs.131431
Enzyme	2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   2.7.11.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	double-stranded RNA binding [Amigo]  double-stranded RNA binding
GO	double-stranded RNA binding [Amigo]  double-stranded RNA binding
GO	protein kinase activity [Amigo]  protein kinase activity
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	eukaryotic translation initiation factor 2alpha kinase activity [Amigo]  eukaryotic translation initiation factor 2alpha kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	intracellular [Amigo]  intracellular
GO	translation [Amigo]  translation
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	virus-infected cell apoptosis [Amigo]  virus-infected cell apoptosis
GO	negative regulation of cell proliferation [Amigo]  negative regulation of cell proliferation
GO	protein phosphatase type 2A regulator activity [Amigo]  protein phosphatase type 2A regulator activity
GO	response to virus [Amigo]  response to virus
GO	transferase activity [Amigo]  transferase activity
GO	endoplasmic reticulum unfolded protein response [Amigo]  endoplasmic reticulum unfolded protein response
GO	interspecies interaction between organisms [Amigo]  interspecies interaction between organisms
GO	protein amino acid autophosphorylation [Amigo]  protein amino acid autophosphorylation
BIOCARTA	Regulation of eIF2    [Genes]
BIOCARTA	Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages    [Genes]
BIOCARTA	Bone Remodelling    [Genes]
BIOCARTA	Double Stranded RNA Induced Gene Expression    [Genes]
BIOCARTA	Toll-Like Receptor Pathway    [Genes]
PubGene	EIF2AK2
TreeFam	EIF2AK2
CTD	5610 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	EIF2AK2 Related clones (RZPD - Berlin)
	PubMed
PubMed	137 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:39:39 2008